Pathology and biology associated with the fragile FHIT gene and gene product

More than 12 years and >800 scientific publications after the discovery of the first gene at a chromosome fragile site, the FHIT gene at FRA3B, there are still questions to pursue concerning the selective advantage conferred to cells by loss of expression of FHIT, the most frequent target of alle...

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Veröffentlicht in:	Journal of cellular biochemistry 2010-04, Vol.109 (5), p.858-865
Hauptverfasser:	Saldivar, Joshua C., Shibata, Hidetaka, Huebner, Kay
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid Anhydride Hydrolases - genetics Acid Anhydride Hydrolases - metabolism Animals common fragile sites DNA damage checkpoint DNA repair FHIT Gene Expression Regulation, Neoplastic Humans Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Neoplasms - genetics Neoplasms - pathology promoter methylation
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container_title	Journal of cellular biochemistry
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creator	Saldivar, Joshua C. Shibata, Hidetaka Huebner, Kay
description	More than 12 years and >800 scientific publications after the discovery of the first gene at a chromosome fragile site, the FHIT gene at FRA3B, there are still questions to pursue concerning the selective advantage conferred to cells by loss of expression of FHIT, the most frequent target of allele deletion in precancerous lesions and cancers. These questions are considered in light of recent investigations of genetic and epigenetic alterations to the locus and in a retrospective consideration of biological roles of the Fhit protein discovered through functional studies. J. Cell. Biochem. 109: 858–865, 2010. © 2010 Wiley‐Liss, Inc.
doi_str_mv	10.1002/jcb.22481
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subjects	Acid Anhydride Hydrolases - genetics Acid Anhydride Hydrolases - metabolism Animals common fragile sites DNA damage checkpoint DNA repair FHIT Gene Expression Regulation, Neoplastic Humans Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Neoplasms - genetics Neoplasms - pathology promoter methylation
title	Pathology and biology associated with the fragile FHIT gene and gene product
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