A five-gene signature as a potential predictor of metastasis and survival in colorectal cancer

To understand the molecular mechanisms of metastasis and prognosis of colorectal cancer (CRC), we isolated single cell‐derived progenies (SCPs) from SW480 cells in vitro and compared their metastatic potential in an orthotopic CRC tumour model in vivo. Two groups of SCPs with the capability of high...

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Veröffentlicht in:	The Journal of pathology 2010-03, Vol.220 (4), p.475-489
Hauptverfasser:	Hao, Jun-Mei, Chen, Juan-Zhi, Sui, Hong-Mei, Si-Ma, Xue-Qing, Li, Guang-Qiu, Liu, Chao, Li, Ji-Liang, Ding, Yan-Qing, Li, Jian-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Proliferation Colorectal cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Dkk1 protein Female Gastroenterology. Liver. Pancreas. Abdomen Gene expression Gene Expression Profiling - methods gene signature Humans Investigative techniques, diagnostic techniques (general aspects) Lymph nodes Lyn protein Male Medical sciences Metastases metastasis Mice Mice, Nude Molecular modelling Neoplasm Metastasis - genetics Neoplasm Metastasis - pathology Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Neoplasm Transplantation Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - physiology Oligonucleotide Array Sequence Analysis - methods Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Progeny Prognosis Reverse Transcriptase Polymerase Chain Reaction - methods single cell-derived progenies Single-cell protein Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Survival Survival Analysis Tumor Cells, Cultured Tumors
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