A Feed-Forward Circuit Controlling Inducible NF-κB Target Gene Activation by Promoter Histone Demethylation

Activation of transcription from a silenced state is crucial to achieve specific gene expression in many biological contexts. Methylation of lysine 9 on histone H3 (H3K9) is widely associated with transcriptional silencing, and its disappearance is linked to the activation of several inflammatory ge...

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Veröffentlicht in:	Molecular cell 2010-09, Vol.39 (5), p.750-760
Hauptverfasser:	van Essen, Dominic, Zhu, Yina, Saccani, Simona
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line CELLIMMUNO Circuits DNA Gene Silencing - physiology Histones - genetics Histones - metabolism Humans Mice Mice, Knockout NF-kappa B - genetics NF-kappa B - metabolism Oxidoreductases, N-Demethylating - genetics Oxidoreductases, N-Demethylating - metabolism Proto-Oncogene Proteins c-rel - genetics Proto-Oncogene Proteins c-rel - metabolism SIGNALING
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