New and emerging technologies for genetic toxicity testing
The International Life Sciences Institute (ILSI) Health and Environmental Sciences Institute (HESI) Project Committee on the Relevance and Follow-up of Positive Results in In Vitro Genetic Toxicity (IVGT) Testing established an Emerging Technologies and New Strategies Workgroup to review the current...
Gespeichert in:
| Veröffentlicht in: | Environmental and molecular mutagenesis 2011-04, Vol.52 (3), p.205-223 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 223 |
|---|---|
| container_issue | 3 |
| container_start_page | 205 |
| container_title | Environmental and molecular mutagenesis |
| container_volume | 52 |
| creator | Lynch, Anthony M Sasaki, Jennifer C Elespuru, Rosalie Jacobson-Kram, David Thybaud, Véronique De Boeck, Marlies Aardema, Marilyn J Aubrecht, Jiri Benz, R. Daniel Dertinger, Stephen D Douglas, George R White, Paul A Escobar, Patricia A Fornace, Albert Jr Honma, Masamitsu Naven, Russell T Rusling, James F Schiestl, Robert H Walmsley, Richard M Yamamura, Eiji van Benthem, Jan Kim, James H |
| description | The International Life Sciences Institute (ILSI) Health and Environmental Sciences Institute (HESI) Project Committee on the Relevance and Follow-up of Positive Results in In Vitro Genetic Toxicity (IVGT) Testing established an Emerging Technologies and New Strategies Workgroup to review the current State of the Art in genetic toxicology testing. The aim of the workgroup was to identify promising technologies that will improve genotoxicity testing and assessment of in vivo hazard and risk, and that have the potential to help meet the objectives of the IVGT. As part of this initiative, HESI convened a workshop in Washington, DC in May 2008 to discuss mature, maturing, and emerging technologies in genetic toxicology. This article collates the abstracts of the New and Emerging Technologies Workshop together with some additional technologies subsequently considered by the workgroup. Each abstract (available in the online version of the article) includes a section addressed specifically to the strengths, weaknesses, opportunities, and threats associated with the respective technology. Importantly, an overview of the technologies and an indication of how their use might be aligned with the objectives of IVGT are presented. In particular, consideration was given with regard to follow-up testing of positive results in the standard IVGT tests (i.e., Salmonella Ames test, chromosome aberration assay, and mouse lymphoma assay) to add weight of evidence and/or provide mechanism of action for improved genetic toxicity risk assessments in humans. Environ. Mol. Mutagen., 2011. |
| doi_str_mv | 10.1002/em.20614 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_968161010</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>968161010</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4444-28cbbc8f607751a74c5d8986314758376879bc8d08ca536c0a0f86c45bfcd2843</originalsourceid><addsrcrecordid>eNp10MtOGzEUBmCrApVAK_UJ6Gwq2Aw9vtvsKEpDBaELilhajsczuMwF7Ikgb19DAl3hzVn40_mPfoS-YDjCAOS7744ICMw-oAkGrUpCFGyhCShNSyE02UG7Kf0FwJhp8hHtEJAMBOUTdHzpHwvbV4XvfGxC3xSjd7f90A5N8Kmoh1g0vvdjcMU4PAUXxlUWaczyE9qubZv8583cQ9c_p39Oz8qL37NfpycXpWP5lUS5xcKpWoCUHFvJHK-UVoJiJrmiUiip838FyllOhQMLtRKO8UXtKqIY3UMH6733cXhY5mzTheR829reD8tktFBYYMCQ5eFaujikFH1t7mPobFwZDOa5KOM781JUpvubpctF56s3-NpMBt82wCZn2zra3oX03zHAQsvnzHLtHkPrV-8Gmun8NXjjQxr905u38c4ISSU3N5czQ9kPmN_Mr8x59l_XvraDsU3MN1xfEcAUsOaEK0L_AUIWlGI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>968161010</pqid></control><display><type>article</type><title>New and emerging technologies for genetic toxicity testing</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Lynch, Anthony M ; Sasaki, Jennifer C ; Elespuru, Rosalie ; Jacobson-Kram, David ; Thybaud, Véronique ; De Boeck, Marlies ; Aardema, Marilyn J ; Aubrecht, Jiri ; Benz, R. Daniel ; Dertinger, Stephen D ; Douglas, George R ; White, Paul A ; Escobar, Patricia A ; Fornace, Albert Jr ; Honma, Masamitsu ; Naven, Russell T ; Rusling, James F ; Schiestl, Robert H ; Walmsley, Richard M ; Yamamura, Eiji ; van Benthem, Jan ; Kim, James H</creator><creatorcontrib>Lynch, Anthony M ; Sasaki, Jennifer C ; Elespuru, Rosalie ; Jacobson-Kram, David ; Thybaud, Véronique ; De Boeck, Marlies ; Aardema, Marilyn J ; Aubrecht, Jiri ; Benz, R. Daniel ; Dertinger, Stephen D ; Douglas, George R ; White, Paul A ; Escobar, Patricia A ; Fornace, Albert Jr ; Honma, Masamitsu ; Naven, Russell T ; Rusling, James F ; Schiestl, Robert H ; Walmsley, Richard M ; Yamamura, Eiji ; van Benthem, Jan ; Kim, James H</creatorcontrib><description>The International Life Sciences Institute (ILSI) Health and Environmental Sciences Institute (HESI) Project Committee on the Relevance and Follow-up of Positive Results in In Vitro Genetic Toxicity (IVGT) Testing established an Emerging Technologies and New Strategies Workgroup to review the current State of the Art in genetic toxicology testing. The aim of the workgroup was to identify promising technologies that will improve genotoxicity testing and assessment of in vivo hazard and risk, and that have the potential to help meet the objectives of the IVGT. As part of this initiative, HESI convened a workshop in Washington, DC in May 2008 to discuss mature, maturing, and emerging technologies in genetic toxicology. This article collates the abstracts of the New and Emerging Technologies Workshop together with some additional technologies subsequently considered by the workgroup. Each abstract (available in the online version of the article) includes a section addressed specifically to the strengths, weaknesses, opportunities, and threats associated with the respective technology. Importantly, an overview of the technologies and an indication of how their use might be aligned with the objectives of IVGT are presented. In particular, consideration was given with regard to follow-up testing of positive results in the standard IVGT tests (i.e., Salmonella Ames test, chromosome aberration assay, and mouse lymphoma assay) to add weight of evidence and/or provide mechanism of action for improved genetic toxicity risk assessments in humans. Environ. Mol. Mutagen., 2011.</description><identifier>ISSN: 0893-6692</identifier><identifier>EISSN: 1098-2280</identifier><identifier>DOI: 10.1002/em.20614</identifier><identifier>PMID: 20740635</identifier><identifier>CODEN: EMMUEG</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>alternatives ; Animals ; Biological and medical sciences ; Consensus Development Conferences as Topic ; Fundamental and applied biological sciences. Psychology ; genetic toxicity ; Genetics of eukaryotes. Biological and molecular evolution ; Humans ; ILSI HESI ; International Cooperation ; Medical sciences ; Mutagenicity Tests - methods ; Mutagenicity Tests - trends ; Mutagens - toxicity ; new technologies ; Risk Assessment ; Salmonella ; Technology ; testing ; Toxicology</subject><ispartof>Environmental and molecular mutagenesis, 2011-04, Vol.52 (3), p.205-223</ispartof><rights>Copyright © 2010 Wiley‐Liss, Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4444-28cbbc8f607751a74c5d8986314758376879bc8d08ca536c0a0f86c45bfcd2843</citedby><cites>FETCH-LOGICAL-c4444-28cbbc8f607751a74c5d8986314758376879bc8d08ca536c0a0f86c45bfcd2843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fem.20614$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fem.20614$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24016970$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20740635$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lynch, Anthony M</creatorcontrib><creatorcontrib>Sasaki, Jennifer C</creatorcontrib><creatorcontrib>Elespuru, Rosalie</creatorcontrib><creatorcontrib>Jacobson-Kram, David</creatorcontrib><creatorcontrib>Thybaud, Véronique</creatorcontrib><creatorcontrib>De Boeck, Marlies</creatorcontrib><creatorcontrib>Aardema, Marilyn J</creatorcontrib><creatorcontrib>Aubrecht, Jiri</creatorcontrib><creatorcontrib>Benz, R. Daniel</creatorcontrib><creatorcontrib>Dertinger, Stephen D</creatorcontrib><creatorcontrib>Douglas, George R</creatorcontrib><creatorcontrib>White, Paul A</creatorcontrib><creatorcontrib>Escobar, Patricia A</creatorcontrib><creatorcontrib>Fornace, Albert Jr</creatorcontrib><creatorcontrib>Honma, Masamitsu</creatorcontrib><creatorcontrib>Naven, Russell T</creatorcontrib><creatorcontrib>Rusling, James F</creatorcontrib><creatorcontrib>Schiestl, Robert H</creatorcontrib><creatorcontrib>Walmsley, Richard M</creatorcontrib><creatorcontrib>Yamamura, Eiji</creatorcontrib><creatorcontrib>van Benthem, Jan</creatorcontrib><creatorcontrib>Kim, James H</creatorcontrib><title>New and emerging technologies for genetic toxicity testing</title><title>Environmental and molecular mutagenesis</title><addtitle>Environ. Mol. Mutagen</addtitle><description>The International Life Sciences Institute (ILSI) Health and Environmental Sciences Institute (HESI) Project Committee on the Relevance and Follow-up of Positive Results in In Vitro Genetic Toxicity (IVGT) Testing established an Emerging Technologies and New Strategies Workgroup to review the current State of the Art in genetic toxicology testing. The aim of the workgroup was to identify promising technologies that will improve genotoxicity testing and assessment of in vivo hazard and risk, and that have the potential to help meet the objectives of the IVGT. As part of this initiative, HESI convened a workshop in Washington, DC in May 2008 to discuss mature, maturing, and emerging technologies in genetic toxicology. This article collates the abstracts of the New and Emerging Technologies Workshop together with some additional technologies subsequently considered by the workgroup. Each abstract (available in the online version of the article) includes a section addressed specifically to the strengths, weaknesses, opportunities, and threats associated with the respective technology. Importantly, an overview of the technologies and an indication of how their use might be aligned with the objectives of IVGT are presented. In particular, consideration was given with regard to follow-up testing of positive results in the standard IVGT tests (i.e., Salmonella Ames test, chromosome aberration assay, and mouse lymphoma assay) to add weight of evidence and/or provide mechanism of action for improved genetic toxicity risk assessments in humans. Environ. Mol. Mutagen., 2011.</description><subject>alternatives</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Consensus Development Conferences as Topic</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>genetic toxicity</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Humans</subject><subject>ILSI HESI</subject><subject>International Cooperation</subject><subject>Medical sciences</subject><subject>Mutagenicity Tests - methods</subject><subject>Mutagenicity Tests - trends</subject><subject>Mutagens - toxicity</subject><subject>new technologies</subject><subject>Risk Assessment</subject><subject>Salmonella</subject><subject>Technology</subject><subject>testing</subject><subject>Toxicology</subject><issn>0893-6692</issn><issn>1098-2280</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10MtOGzEUBmCrApVAK_UJ6Gwq2Aw9vtvsKEpDBaELilhajsczuMwF7Ikgb19DAl3hzVn40_mPfoS-YDjCAOS7744ICMw-oAkGrUpCFGyhCShNSyE02UG7Kf0FwJhp8hHtEJAMBOUTdHzpHwvbV4XvfGxC3xSjd7f90A5N8Kmoh1g0vvdjcMU4PAUXxlUWaczyE9qubZv8583cQ9c_p39Oz8qL37NfpycXpWP5lUS5xcKpWoCUHFvJHK-UVoJiJrmiUiip838FyllOhQMLtRKO8UXtKqIY3UMH6733cXhY5mzTheR829reD8tktFBYYMCQ5eFaujikFH1t7mPobFwZDOa5KOM781JUpvubpctF56s3-NpMBt82wCZn2zra3oX03zHAQsvnzHLtHkPrV-8Gmun8NXjjQxr905u38c4ISSU3N5czQ9kPmN_Mr8x59l_XvraDsU3MN1xfEcAUsOaEK0L_AUIWlGI</recordid><startdate>201104</startdate><enddate>201104</enddate><creator>Lynch, Anthony M</creator><creator>Sasaki, Jennifer C</creator><creator>Elespuru, Rosalie</creator><creator>Jacobson-Kram, David</creator><creator>Thybaud, Véronique</creator><creator>De Boeck, Marlies</creator><creator>Aardema, Marilyn J</creator><creator>Aubrecht, Jiri</creator><creator>Benz, R. Daniel</creator><creator>Dertinger, Stephen D</creator><creator>Douglas, George R</creator><creator>White, Paul A</creator><creator>Escobar, Patricia A</creator><creator>Fornace, Albert Jr</creator><creator>Honma, Masamitsu</creator><creator>Naven, Russell T</creator><creator>Rusling, James F</creator><creator>Schiestl, Robert H</creator><creator>Walmsley, Richard M</creator><creator>Yamamura, Eiji</creator><creator>van Benthem, Jan</creator><creator>Kim, James H</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U1</scope><scope>7U2</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>201104</creationdate><title>New and emerging technologies for genetic toxicity testing</title><author>Lynch, Anthony M ; Sasaki, Jennifer C ; Elespuru, Rosalie ; Jacobson-Kram, David ; Thybaud, Véronique ; De Boeck, Marlies ; Aardema, Marilyn J ; Aubrecht, Jiri ; Benz, R. Daniel ; Dertinger, Stephen D ; Douglas, George R ; White, Paul A ; Escobar, Patricia A ; Fornace, Albert Jr ; Honma, Masamitsu ; Naven, Russell T ; Rusling, James F ; Schiestl, Robert H ; Walmsley, Richard M ; Yamamura, Eiji ; van Benthem, Jan ; Kim, James H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4444-28cbbc8f607751a74c5d8986314758376879bc8d08ca536c0a0f86c45bfcd2843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>alternatives</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Consensus Development Conferences as Topic</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>genetic toxicity</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Humans</topic><topic>ILSI HESI</topic><topic>International Cooperation</topic><topic>Medical sciences</topic><topic>Mutagenicity Tests - methods</topic><topic>Mutagenicity Tests - trends</topic><topic>Mutagens - toxicity</topic><topic>new technologies</topic><topic>Risk Assessment</topic><topic>Salmonella</topic><topic>Technology</topic><topic>testing</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lynch, Anthony M</creatorcontrib><creatorcontrib>Sasaki, Jennifer C</creatorcontrib><creatorcontrib>Elespuru, Rosalie</creatorcontrib><creatorcontrib>Jacobson-Kram, David</creatorcontrib><creatorcontrib>Thybaud, Véronique</creatorcontrib><creatorcontrib>De Boeck, Marlies</creatorcontrib><creatorcontrib>Aardema, Marilyn J</creatorcontrib><creatorcontrib>Aubrecht, Jiri</creatorcontrib><creatorcontrib>Benz, R. Daniel</creatorcontrib><creatorcontrib>Dertinger, Stephen D</creatorcontrib><creatorcontrib>Douglas, George R</creatorcontrib><creatorcontrib>White, Paul A</creatorcontrib><creatorcontrib>Escobar, Patricia A</creatorcontrib><creatorcontrib>Fornace, Albert Jr</creatorcontrib><creatorcontrib>Honma, Masamitsu</creatorcontrib><creatorcontrib>Naven, Russell T</creatorcontrib><creatorcontrib>Rusling, James F</creatorcontrib><creatorcontrib>Schiestl, Robert H</creatorcontrib><creatorcontrib>Walmsley, Richard M</creatorcontrib><creatorcontrib>Yamamura, Eiji</creatorcontrib><creatorcontrib>van Benthem, Jan</creatorcontrib><creatorcontrib>Kim, James H</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Environmental and molecular mutagenesis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lynch, Anthony M</au><au>Sasaki, Jennifer C</au><au>Elespuru, Rosalie</au><au>Jacobson-Kram, David</au><au>Thybaud, Véronique</au><au>De Boeck, Marlies</au><au>Aardema, Marilyn J</au><au>Aubrecht, Jiri</au><au>Benz, R. Daniel</au><au>Dertinger, Stephen D</au><au>Douglas, George R</au><au>White, Paul A</au><au>Escobar, Patricia A</au><au>Fornace, Albert Jr</au><au>Honma, Masamitsu</au><au>Naven, Russell T</au><au>Rusling, James F</au><au>Schiestl, Robert H</au><au>Walmsley, Richard M</au><au>Yamamura, Eiji</au><au>van Benthem, Jan</au><au>Kim, James H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New and emerging technologies for genetic toxicity testing</atitle><jtitle>Environmental and molecular mutagenesis</jtitle><addtitle>Environ. Mol. Mutagen</addtitle><date>2011-04</date><risdate>2011</risdate><volume>52</volume><issue>3</issue><spage>205</spage><epage>223</epage><pages>205-223</pages><issn>0893-6692</issn><eissn>1098-2280</eissn><coden>EMMUEG</coden><abstract>The International Life Sciences Institute (ILSI) Health and Environmental Sciences Institute (HESI) Project Committee on the Relevance and Follow-up of Positive Results in In Vitro Genetic Toxicity (IVGT) Testing established an Emerging Technologies and New Strategies Workgroup to review the current State of the Art in genetic toxicology testing. The aim of the workgroup was to identify promising technologies that will improve genotoxicity testing and assessment of in vivo hazard and risk, and that have the potential to help meet the objectives of the IVGT. As part of this initiative, HESI convened a workshop in Washington, DC in May 2008 to discuss mature, maturing, and emerging technologies in genetic toxicology. This article collates the abstracts of the New and Emerging Technologies Workshop together with some additional technologies subsequently considered by the workgroup. Each abstract (available in the online version of the article) includes a section addressed specifically to the strengths, weaknesses, opportunities, and threats associated with the respective technology. Importantly, an overview of the technologies and an indication of how their use might be aligned with the objectives of IVGT are presented. In particular, consideration was given with regard to follow-up testing of positive results in the standard IVGT tests (i.e., Salmonella Ames test, chromosome aberration assay, and mouse lymphoma assay) to add weight of evidence and/or provide mechanism of action for improved genetic toxicity risk assessments in humans. Environ. Mol. Mutagen., 2011.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>20740635</pmid><doi>10.1002/em.20614</doi><tpages>19</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0893-6692 |
| ispartof | Environmental and molecular mutagenesis, 2011-04, Vol.52 (3), p.205-223 |
| issn | 0893-6692 1098-2280 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_968161010 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | alternatives Animals Biological and medical sciences Consensus Development Conferences as Topic Fundamental and applied biological sciences. Psychology genetic toxicity Genetics of eukaryotes. Biological and molecular evolution Humans ILSI HESI International Cooperation Medical sciences Mutagenicity Tests - methods Mutagenicity Tests - trends Mutagens - toxicity new technologies Risk Assessment Salmonella Technology testing Toxicology |
| title | New and emerging technologies for genetic toxicity testing |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T04%3A43%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=New%20and%20emerging%20technologies%20for%20genetic%20toxicity%20testing&rft.jtitle=Environmental%20and%20molecular%20mutagenesis&rft.au=Lynch,%20Anthony%20M&rft.date=2011-04&rft.volume=52&rft.issue=3&rft.spage=205&rft.epage=223&rft.pages=205-223&rft.issn=0893-6692&rft.eissn=1098-2280&rft.coden=EMMUEG&rft_id=info:doi/10.1002/em.20614&rft_dat=%3Cproquest_cross%3E968161010%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=968161010&rft_id=info:pmid/20740635&rfr_iscdi=true |