$PTEN genomic deletion is associated with p-Akt and AR signalling in poorer outcome, hormone refractory prostate cancer$

PTEN genomic deletion is associated with p-Akt and AR signalling in poorer outcome, hormone refractory prostate cancer

PTEN haploinsufficiency is common in hormone-sensitive prostate cancer, though the incidence of genomic deletion and its downstream effects have not been elucidated in clinical samples of hormone refractory prostate cancer (HRPC). Progression to androgen independence is pivotal in prostate cancer an...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of pathology 2009-08, Vol.218 (4), p.505-513
Hauptverfasser:	Sircar, Kanishka, Yoshimoto, Maisa, Monzon, Federico A, Koumakpayi, Ismael H, Katz, Ruth L, Khanna, Abha, Alvarez, Karla, Chen, Guanyong, Darnel, Andrew D, Aprikian, Armen G, Saad, Fred, Bismar, Tarek A, Squire, Jeremy A
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over AKT protein Androgen Antagonists - therapeutic use Androgen receptors Androgens Antibodies Bacterial artificial chromosomes Biological and medical sciences chromosome 10 Chromosomes, Human, Pair 10 copy number DNA probes FISH Fluorescence in situ hybridization Gene Deletion Genome genomics Genotype haploinsufficiency Hormones Humans Immunohistochemistry In Situ Hybridization, Fluorescence Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Metastases microarray Middle Aged Mortality Nephrology. Urinary tract diseases Oligonucleotide Array Sequence Analysis Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Phenotype Polymorphism, Single Nucleotide prognosis Prostate cancer Prostatic Neoplasms - drug therapy Prostatic Neoplasms - metabolism Proto-Oncogene Proteins c-akt - metabolism PTEN PTEN Phosphohydrolase - analysis PTEN Phosphohydrolase - genetics PTEN protein Receptors, Androgen - metabolism Signal transduction Signal Transduction - genetics Single-nucleotide polymorphism Statistics, Nonparametric Treatment Failure Tumors of the urinary system tumour suppressor gene Urinary tract. Prostate gland
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!