Plasma sCD36 is associated with markers of atherosclerosis, insulin resistance and fatty liver in a nondiabetic healthy population
. Handberg A, Højlund K, Gastaldelli A, Flyvbjerg A, Dekker JM, Petrie J, Piatti P, Beck‐Nielsen H (Aarhus Hospital and Aalborg Hospital, Aarhus University Hospital, Aarhus, Denmark; Odense University Hospital, Odense, Denmark; Institute of Clinical Physiology, CNR Pisa, Pisa, Italy; Aarhus Univers...
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| description | . Handberg A, Højlund K, Gastaldelli A, Flyvbjerg A, Dekker JM, Petrie J, Piatti P, Beck‐Nielsen H (Aarhus Hospital and Aalborg Hospital, Aarhus University Hospital, Aarhus, Denmark; Odense University Hospital, Odense, Denmark; Institute of Clinical Physiology, CNR Pisa, Pisa, Italy; Aarhus University Hospital, Aarhus, Denmark; Vrije Universiteit Amsterdam, Amsterdam, The Netherlands; BHF Glasgow Cardiovascular Research Centre, Glasgow, UK; and San Raffaele Institute, Milan, Italy). Plasma sCD36 is associated with markers of atherosclerosis, insulin resistance and fatty liver in a nondiabetic healthy population. J Intern Med 2012; 271: 294–304.
Objectives. Insulin resistance is associated with increased CD36 expression in a number of tissues. Moreover, excess macrophage CD36 may initiate atherosclerotic lesions. The aim of this study was to determine whether plasma soluble CD36 (sCD36) was associated with insulin resistance, fatty liver and carotid atherosclerosis in nondiabetic subjects.
Methods. In 1296 healthy subjects without diabetes or hypertension recruited from 19 centres in 14 European countries (RISC study), we determined the levels of sCD36, adiponectin, lipids and liver enzymes, insulin sensitivity (M/I) by euglycaemic–hyperinsulinaemic clamp, carotid atherosclerosis as intima–media thickness (IMT) and two estimates of fatty liver, the fatty liver index (FLI) and liver fat percentage (LF%).
Results. IMT, FLI, LF%, presence of the metabolic syndrome, impaired glucose regulation, insulin and triglycerides increased across sCD36 quartiles (Q2–Q4), whereas adiponectin and M/I decreased (P ≤ 0.01). sCD36 was lower in women than in men (P = 0.045). Log sCD36 showed a bimodal distribution, and amongst subjects with sCD36 within the log‐normal distribution (log‐normal population, n = 1029), sCD36 was increased in subjects with impaired glucose regulation (P = 0.045), metabolic syndrome (P = 0.006) or increased likelihood of fatty liver (P |
| doi_str_mv | 10.1111/j.1365-2796.2011.02442.x |
| format | Article |
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Objectives. Insulin resistance is associated with increased CD36 expression in a number of tissues. Moreover, excess macrophage CD36 may initiate atherosclerotic lesions. The aim of this study was to determine whether plasma soluble CD36 (sCD36) was associated with insulin resistance, fatty liver and carotid atherosclerosis in nondiabetic subjects.
Methods. In 1296 healthy subjects without diabetes or hypertension recruited from 19 centres in 14 European countries (RISC study), we determined the levels of sCD36, adiponectin, lipids and liver enzymes, insulin sensitivity (M/I) by euglycaemic–hyperinsulinaemic clamp, carotid atherosclerosis as intima–media thickness (IMT) and two estimates of fatty liver, the fatty liver index (FLI) and liver fat percentage (LF%).
Results. IMT, FLI, LF%, presence of the metabolic syndrome, impaired glucose regulation, insulin and triglycerides increased across sCD36 quartiles (Q2–Q4), whereas adiponectin and M/I decreased (P ≤ 0.01). sCD36 was lower in women than in men (P = 0.045). Log sCD36 showed a bimodal distribution, and amongst subjects with sCD36 within the log‐normal distribution (log‐normal population, n = 1029), sCD36 was increased in subjects with impaired glucose regulation (P = 0.045), metabolic syndrome (P = 0.006) or increased likelihood of fatty liver (P < 0.001). sCD36 correlated significantly with insulin, triglycerides, M/I and FLI (P < 0.05) after adjustment for study centre, gender, age, glucose tolerance status, smoking habits and alcohol consumption. In the log‐normal population, these relationships were stronger than in the total study population and, additionally, sCD36 was significantly associated with LF% and IMT (P < 0.05).
Conclusions. In this cross‐sectional study of nondiabetic subjects, sCD36 was significantly associated with indices of insulin resistance, carotid atherosclerosis and fatty liver. Prospective studies are needed to further evaluate the role of sCD36 in the inter‐relationship between atherosclerosis, fatty liver and insulin resistance.</description><identifier>ISSN: 0954-6820</identifier><identifier>EISSN: 1365-2796</identifier><identifier>DOI: 10.1111/j.1365-2796.2011.02442.x</identifier><identifier>PMID: 21883535</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Algorithms ; Atherosclerosis (general aspects, experimental research) ; Atherosclerosis - blood ; Biological and medical sciences ; Biomarkers - blood ; Blood and lymphatic vessels ; Body Mass Index ; Cardiology. Vascular system ; CD36 Antigens - blood ; Cohort Studies ; Cross-Sectional Studies ; Diabetes Mellitus - blood ; Enzyme-Linked Immunosorbent Assay ; Europe ; Fatty Liver - blood ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; General aspects ; Humans ; Insulin Resistance - physiology ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; low-grade inflammation ; Male ; Medical sciences ; metabolic syndrome ; Middle Aged ; nonalcoholic fatty liver disease ; Other diseases. Semiology ; Predictive Value of Tests ; Prospective Studies ; sCD36 ; type 2 diabetes</subject><ispartof>Journal of internal medicine, 2012-03, Vol.271 (3), p.294-304</ispartof><rights>2011 The Association for the Publication of the Journal of Internal Medicine</rights><rights>2015 INIST-CNRS</rights><rights>2011 The Association for the Publication of the Journal of Internal Medicine.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4872-199ea5b23e9400e7bbc50245c447da88f794279abfbc0012041ac03c12e53db33</citedby><cites>FETCH-LOGICAL-c4872-199ea5b23e9400e7bbc50245c447da88f794279abfbc0012041ac03c12e53db33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2796.2011.02442.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2796.2011.02442.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25566080$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21883535$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Handberg, A.</creatorcontrib><creatorcontrib>Højlund, K.</creatorcontrib><creatorcontrib>Gastaldelli, A.</creatorcontrib><creatorcontrib>Flyvbjerg, A.</creatorcontrib><creatorcontrib>Dekker, J. M.</creatorcontrib><creatorcontrib>Petrie, J.</creatorcontrib><creatorcontrib>Piatti, P.</creatorcontrib><creatorcontrib>Beck-Nielsen, H.</creatorcontrib><creatorcontrib>RISC Investigators</creatorcontrib><creatorcontrib>the RISC Investigators</creatorcontrib><title>Plasma sCD36 is associated with markers of atherosclerosis, insulin resistance and fatty liver in a nondiabetic healthy population</title><title>Journal of internal medicine</title><addtitle>J Intern Med</addtitle><description>. Handberg A, Højlund K, Gastaldelli A, Flyvbjerg A, Dekker JM, Petrie J, Piatti P, Beck‐Nielsen H (Aarhus Hospital and Aalborg Hospital, Aarhus University Hospital, Aarhus, Denmark; Odense University Hospital, Odense, Denmark; Institute of Clinical Physiology, CNR Pisa, Pisa, Italy; Aarhus University Hospital, Aarhus, Denmark; Vrije Universiteit Amsterdam, Amsterdam, The Netherlands; BHF Glasgow Cardiovascular Research Centre, Glasgow, UK; and San Raffaele Institute, Milan, Italy). Plasma sCD36 is associated with markers of atherosclerosis, insulin resistance and fatty liver in a nondiabetic healthy population. J Intern Med 2012; 271: 294–304.
Objectives. Insulin resistance is associated with increased CD36 expression in a number of tissues. Moreover, excess macrophage CD36 may initiate atherosclerotic lesions. The aim of this study was to determine whether plasma soluble CD36 (sCD36) was associated with insulin resistance, fatty liver and carotid atherosclerosis in nondiabetic subjects.
Methods. In 1296 healthy subjects without diabetes or hypertension recruited from 19 centres in 14 European countries (RISC study), we determined the levels of sCD36, adiponectin, lipids and liver enzymes, insulin sensitivity (M/I) by euglycaemic–hyperinsulinaemic clamp, carotid atherosclerosis as intima–media thickness (IMT) and two estimates of fatty liver, the fatty liver index (FLI) and liver fat percentage (LF%).
Results. IMT, FLI, LF%, presence of the metabolic syndrome, impaired glucose regulation, insulin and triglycerides increased across sCD36 quartiles (Q2–Q4), whereas adiponectin and M/I decreased (P ≤ 0.01). sCD36 was lower in women than in men (P = 0.045). Log sCD36 showed a bimodal distribution, and amongst subjects with sCD36 within the log‐normal distribution (log‐normal population, n = 1029), sCD36 was increased in subjects with impaired glucose regulation (P = 0.045), metabolic syndrome (P = 0.006) or increased likelihood of fatty liver (P < 0.001). sCD36 correlated significantly with insulin, triglycerides, M/I and FLI (P < 0.05) after adjustment for study centre, gender, age, glucose tolerance status, smoking habits and alcohol consumption. In the log‐normal population, these relationships were stronger than in the total study population and, additionally, sCD36 was significantly associated with LF% and IMT (P < 0.05).
Conclusions. In this cross‐sectional study of nondiabetic subjects, sCD36 was significantly associated with indices of insulin resistance, carotid atherosclerosis and fatty liver. Prospective studies are needed to further evaluate the role of sCD36 in the inter‐relationship between atherosclerosis, fatty liver and insulin resistance.</description><subject>Adult</subject><subject>Algorithms</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Atherosclerosis - blood</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Blood and lymphatic vessels</subject><subject>Body Mass Index</subject><subject>Cardiology. Vascular system</subject><subject>CD36 Antigens - blood</subject><subject>Cohort Studies</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes Mellitus - blood</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Europe</subject><subject>Fatty Liver - blood</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>General aspects</subject><subject>Humans</subject><subject>Insulin Resistance - physiology</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>low-grade inflammation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>metabolic syndrome</subject><subject>Middle Aged</subject><subject>nonalcoholic fatty liver disease</subject><subject>Other diseases. Semiology</subject><subject>Predictive Value of Tests</subject><subject>Prospective Studies</subject><subject>sCD36</subject><subject>type 2 diabetes</subject><issn>0954-6820</issn><issn>1365-2796</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUuP0zAUhSMEYjoDfwF5g9iQ4GfibJBQYR4wMCMEgp1149yoLm5SYnem3fLLcWgpW7zwQ_7use85WUYYLVgar5YFE6XKeVWXBaeMFZRLyYvtg2x2vHiYzWitZF5qTk-y0xCWlDJBS_o4O-FMa6GEmmW_bj2EFZAwfytK4gKBEAbrIGJL7l1ckBWMP3AMZOgIxAWOQ7B-ml14SVwfNt71ZMR0jNBbJNC3pIMYd8S7OxwTQoD0Q986aDA6SxYIPi52ZD2sNx6iG_on2aMOfMCnh_Us-3r-7sv8Mr--ubiav7nOrdQVz1ldI6iGC6wlpVg1jVWpbWWlrFrQuqtqmfqGpmts6pRTycBSYRlHJdpGiLPsxV53PQ4_NxiiWblg0XvocdgEU5eaMUpVlUi9J21qNIzYmfXokhE7w6iZAjBLM_lsJp_NFID5E4DZptJnh0c2zQrbY-FfxxPw_ABAsOC7Mdnmwj9OqbKkmibu9Z67dx53__0B8_7m6uO0TQL5XiBFg9ujQIrTlJWolPn26cJ8lrcfzi-_a6PEb7Vesfs</recordid><startdate>201203</startdate><enddate>201203</enddate><creator>Handberg, A.</creator><creator>Højlund, K.</creator><creator>Gastaldelli, A.</creator><creator>Flyvbjerg, A.</creator><creator>Dekker, J. M.</creator><creator>Petrie, J.</creator><creator>Piatti, P.</creator><creator>Beck-Nielsen, H.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201203</creationdate><title>Plasma sCD36 is associated with markers of atherosclerosis, insulin resistance and fatty liver in a nondiabetic healthy population</title><author>Handberg, A. ; Højlund, K. ; Gastaldelli, A. ; Flyvbjerg, A. ; Dekker, J. M. ; Petrie, J. ; Piatti, P. ; Beck-Nielsen, H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4872-199ea5b23e9400e7bbc50245c447da88f794279abfbc0012041ac03c12e53db33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Algorithms</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Atherosclerosis - blood</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Blood and lymphatic vessels</topic><topic>Body Mass Index</topic><topic>Cardiology. Vascular system</topic><topic>CD36 Antigens - blood</topic><topic>Cohort Studies</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes Mellitus - blood</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Europe</topic><topic>Fatty Liver - blood</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>General aspects</topic><topic>Humans</topic><topic>Insulin Resistance - physiology</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>low-grade inflammation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>metabolic syndrome</topic><topic>Middle Aged</topic><topic>nonalcoholic fatty liver disease</topic><topic>Other diseases. Semiology</topic><topic>Predictive Value of Tests</topic><topic>Prospective Studies</topic><topic>sCD36</topic><topic>type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Handberg, A.</creatorcontrib><creatorcontrib>Højlund, K.</creatorcontrib><creatorcontrib>Gastaldelli, A.</creatorcontrib><creatorcontrib>Flyvbjerg, A.</creatorcontrib><creatorcontrib>Dekker, J. M.</creatorcontrib><creatorcontrib>Petrie, J.</creatorcontrib><creatorcontrib>Piatti, P.</creatorcontrib><creatorcontrib>Beck-Nielsen, H.</creatorcontrib><creatorcontrib>RISC Investigators</creatorcontrib><creatorcontrib>the RISC Investigators</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of internal medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Handberg, A.</au><au>Højlund, K.</au><au>Gastaldelli, A.</au><au>Flyvbjerg, A.</au><au>Dekker, J. M.</au><au>Petrie, J.</au><au>Piatti, P.</au><au>Beck-Nielsen, H.</au><aucorp>RISC Investigators</aucorp><aucorp>the RISC Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma sCD36 is associated with markers of atherosclerosis, insulin resistance and fatty liver in a nondiabetic healthy population</atitle><jtitle>Journal of internal medicine</jtitle><addtitle>J Intern Med</addtitle><date>2012-03</date><risdate>2012</risdate><volume>271</volume><issue>3</issue><spage>294</spage><epage>304</epage><pages>294-304</pages><issn>0954-6820</issn><eissn>1365-2796</eissn><abstract>. Handberg A, Højlund K, Gastaldelli A, Flyvbjerg A, Dekker JM, Petrie J, Piatti P, Beck‐Nielsen H (Aarhus Hospital and Aalborg Hospital, Aarhus University Hospital, Aarhus, Denmark; Odense University Hospital, Odense, Denmark; Institute of Clinical Physiology, CNR Pisa, Pisa, Italy; Aarhus University Hospital, Aarhus, Denmark; Vrije Universiteit Amsterdam, Amsterdam, The Netherlands; BHF Glasgow Cardiovascular Research Centre, Glasgow, UK; and San Raffaele Institute, Milan, Italy). Plasma sCD36 is associated with markers of atherosclerosis, insulin resistance and fatty liver in a nondiabetic healthy population. J Intern Med 2012; 271: 294–304.
Objectives. Insulin resistance is associated with increased CD36 expression in a number of tissues. Moreover, excess macrophage CD36 may initiate atherosclerotic lesions. The aim of this study was to determine whether plasma soluble CD36 (sCD36) was associated with insulin resistance, fatty liver and carotid atherosclerosis in nondiabetic subjects.
Methods. In 1296 healthy subjects without diabetes or hypertension recruited from 19 centres in 14 European countries (RISC study), we determined the levels of sCD36, adiponectin, lipids and liver enzymes, insulin sensitivity (M/I) by euglycaemic–hyperinsulinaemic clamp, carotid atherosclerosis as intima–media thickness (IMT) and two estimates of fatty liver, the fatty liver index (FLI) and liver fat percentage (LF%).
Results. IMT, FLI, LF%, presence of the metabolic syndrome, impaired glucose regulation, insulin and triglycerides increased across sCD36 quartiles (Q2–Q4), whereas adiponectin and M/I decreased (P ≤ 0.01). sCD36 was lower in women than in men (P = 0.045). Log sCD36 showed a bimodal distribution, and amongst subjects with sCD36 within the log‐normal distribution (log‐normal population, n = 1029), sCD36 was increased in subjects with impaired glucose regulation (P = 0.045), metabolic syndrome (P = 0.006) or increased likelihood of fatty liver (P < 0.001). sCD36 correlated significantly with insulin, triglycerides, M/I and FLI (P < 0.05) after adjustment for study centre, gender, age, glucose tolerance status, smoking habits and alcohol consumption. In the log‐normal population, these relationships were stronger than in the total study population and, additionally, sCD36 was significantly associated with LF% and IMT (P < 0.05).
Conclusions. In this cross‐sectional study of nondiabetic subjects, sCD36 was significantly associated with indices of insulin resistance, carotid atherosclerosis and fatty liver. Prospective studies are needed to further evaluate the role of sCD36 in the inter‐relationship between atherosclerosis, fatty liver and insulin resistance.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21883535</pmid><doi>10.1111/j.1365-2796.2011.02442.x</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of internal medicine, 2012-03, Vol.271 (3), p.294-304 |
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| source | MEDLINE; IngentaConnect Free/Open Access Journals; Wiley Online Library Journals Frontfile Complete; Wiley Online Library Free Content; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Algorithms Atherosclerosis (general aspects, experimental research) Atherosclerosis - blood Biological and medical sciences Biomarkers - blood Blood and lymphatic vessels Body Mass Index Cardiology. Vascular system CD36 Antigens - blood Cohort Studies Cross-Sectional Studies Diabetes Mellitus - blood Enzyme-Linked Immunosorbent Assay Europe Fatty Liver - blood Female Gastroenterology. Liver. Pancreas. Abdomen General aspects Humans Insulin Resistance - physiology Liver. Biliary tract. Portal circulation. Exocrine pancreas low-grade inflammation Male Medical sciences metabolic syndrome Middle Aged nonalcoholic fatty liver disease Other diseases. Semiology Predictive Value of Tests Prospective Studies sCD36 type 2 diabetes |
| title | Plasma sCD36 is associated with markers of atherosclerosis, insulin resistance and fatty liver in a nondiabetic healthy population |
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