A Bioinformatics Search for Selective Histamine H4 Receptor Antagonists Through Structure-Based Virtual Screening Strategies

The prevalence of allergic disease is increasing dramatically in the developed world. Studies of allergic diseases have clearly demonstrated that histamine plays an important role in the pathogenesis of the early‐phase allergic response. Histamine effects are mediated by H1, H2, H3, and H4 receptors...

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Veröffentlicht in:	Chemical biology & drug design 2012-05, Vol.79 (5), p.749-759
Hauptverfasser:	Christopher, Fenila, Thangam, Elden Berla, Suresh, Muthaiyan Xavier
Format:	Artikel
Sprache:	eng
Schlagworte:	Antagonist Benzimidazoles - chemistry Benzimidazoles - pharmacology Binding Sites Computational Biology - methods Drug Design Histamine Antagonists - chemistry Histamine Antagonists - pharmacology Histamine H4 receptor Humans Indoles - chemistry Indoles - pharmacology Molecular Dynamics Simulation Piperazines - chemistry Piperazines - pharmacology Piperidines - chemistry Piperidines - pharmacology Receptors, G-Protein-Coupled - antagonists & inhibitors Receptors, G-Protein-Coupled - metabolism Receptors, Histamine - metabolism Receptors, Histamine H4 structure-based drug design virtual screening
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