Effect of Angiotensin II on Inflammation Pathways in Human Primary Bone Cell Cultures in Otosclerosis

Introduction: The aim of this study was to assess the expression and production of inflammation mediators in basal condition and after angiotensin II (AngII) in otosclerosis. Materials and Methods: Human stapedial cell cultures (6 otosclerosis and 6 controls) were incubated with AngII (10 –7 M, 24 h...

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Veröffentlicht in:	Audiology & neurotology 2012-04, Vol.17 (3), p.169-178
Hauptverfasser:	Rudić, Milan, Nguyen, Christine, Nguyen, Yann, Milković, Lidija, Žarković, Neven, Sterkers, Olivier, Ferrary, Evelyne, Bozorg Grayeli, Alexis
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Angiotensin II Angiotensin II - pharmacology Antibodies Audiology Biological and medical sciences Bone Bones Cell culture Cells, Cultured Chemokine CCL3 - metabolism Chemokine CXCL10 - biosynthesis DNA microarrays Ear diseases Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology Female gamma -Interferon Gene expression Hearing loss Humans Inflammation Inflammation - metabolism Inflammation - pathology Interleukin 10 Interleukin-1 - biosynthesis IP-10 protein Macrophage inflammatory protein Male Medical sciences Middle Aged Non tumoral diseases Original Paper Osteocytes - drug effects Osteocytes - metabolism Osteocytes - pathology Otorhinolaryngology. Stomatology Otosclerosis - metabolism Otosclerosis - pathology Receptors, Tumor Necrosis Factor - metabolism Signal Transduction - drug effects Stapes - drug effects Stapes - metabolism Stapes - pathology Tissue inhibitor of metalloproteinase 2 Tissue Inhibitor of Metalloproteinase-2 - biosynthesis Tumor necrosis factor receptors
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