Cytomegalovirus‐Specific Regulatory and Effector T Cells Share TCR Clonality—Possible Relation to Repetitive CMV Infections

Cytomegalovirus (CMV) infections have a major impact on morbidity and mortality of transplant patients. Among the complex antiviral T‐cell response, CMV‐IE‐1 antigen‐specific CD8+ cells are crucial for preventing CMV disease but do not protect from recurring/lasting CMV reactivation. Recently, we co...

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Veröffentlicht in:	American journal of transplantation 2012-03, Vol.12 (3), p.669-681
Hauptverfasser:	Schwele, S., Fischer, A. M., Brestrich, G., Wlodarski, M. W., Wagner, L., Schmueck, M., Roemhild, A., Thomas, S., Hammer, M. H., Babel, N., Kurtz, A., Maciejewski, J. P., Reinke, P., Volk, H.‐D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive transfer Antigens, Viral - immunology Autografts Biological and medical sciences CD25 antigen CD4 antigen CD8 antigen Cell Proliferation CMV infection Cytokines - metabolism Cytomegalovirus Cytomegalovirus - immunology Cytomegalovirus Infections - immunology Cytomegalovirus Infections - microbiology Effector cells Epitopes Flow Cytometry Foxp3 protein Humans Immunoregulation induced regulatory T cells Infection Infectious diseases Kidney transplantation Lymphocytes T Medical sciences Morbidity Mortality Receptors, Antigen, T-Cell - immunology Receptors, Antigen, T-Cell - metabolism Recurrence solid organ transplantation Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases T-cell receptor T-Lymphocytes - immunology T-Lymphocytes, Regulatory - immunology TCR clonality Viral diseases
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