Frequency of Driver Mutations in Lung Adenocarcinoma from Female Never-Smokers Varies with Histologic Subtypes and Age at Diagnosis

Our previous study revealed that 90% [47 of 52; 95% confidence interval (CI), 0.79-0.96] of Chinese never-smokers with lung adenocarcinoma harbor known oncogenic driver mutations in just four genes EGFR, ALK, HER2, and KRAS. Here, we examined the status of known driver mutations specifically in fema...

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Veröffentlicht in:	Clinical cancer research 2012-04, Vol.18 (7), p.1947-1953
Hauptverfasser:	Zhang, Yang, Sun, Yihua, Pan, Yunjian, Li, Chenguang, Shen, Lei, Li, Yuan, Luo, Xiaoyang, Ye, Ting, Wang, Rui, Hu, Haichuan, Li, Hang, Wang, Lei, Pao, William, Chen, Haiquan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics Adenocarcinoma - pathology Adult Age Factors Aged Aged, 80 and over Antineoplastic agents Biological and medical sciences DNA Mutational Analysis Female Gene Frequency Genotype Humans Logistic Models Lung Neoplasms - genetics Lung Neoplasms - pathology Medical sciences Middle Aged Multivariate Analysis Mutation Neoplasm Staging Oncogenes - genetics Pharmacology. Drug treatments Pneumology Proto-Oncogene Proteins B-raf - genetics ras Proteins - genetics Receptor Protein-Tyrosine Kinases - genetics Receptor, Epidermal Growth Factor - genetics Receptor, ErbB-2 - genetics Smoking Tobacco, tobacco smoking Toxicology Tumors of the respiratory system and mediastinum Young Adult
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