Preclinical Evaluation of TriMix and Antigen mRNA-Based Antitumor Therapy

The use of tumor-associated antigen (TAA) mRNA for therapeutic purposes is under active investigation. To be effective, mRNA vaccines need to deliver activation stimuli in addition to TAAs to dendritic cells (DC). In this study, we evaluated whether intranodal delivery of TAA mRNA together with TriM...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2012-04, Vol.72 (7), p.1661-1671
Hauptverfasser:	VAN LINT, Sandra, GOYVAERTS, Cleo, THIELEMANS, Kris, MAENHOUT, Sarah, GOETHALS, Lode, DISY, Aurélie, BENTEYN, Daphne, PEN, Joeri, BONEHILL, Aude, HEIRMAN, Carlo, BRECKPOT, Karine
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animal models Animals Antigen (tumor-associated) Antigens, Neoplasm - genetics Antineoplastic agents Biological and medical sciences Cancer CD11c antigen CD11c Antigen - analysis CD27 Ligand - genetics CD4 antigen CD40 antigen CD40 Ligand - genetics CD70 antigen CD8 antigen Cell activation Cytotoxicity Dendritic cells Dendritic Cells - immunology Electrochemotherapy Female Lymph nodes Lymphocyte Activation Lymphocytes T Medical sciences Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred DBA Molecular Sequence Data Neoplasms, Experimental - immunology Neoplasms, Experimental - therapy Pharmacology. Drug treatments RNA, Messenger - immunology RNA, Messenger - pharmacokinetics T-Lymphocytes - immunology Therapeutic applications TLR4 protein Toll-Like Receptor 4 - genetics Toll-like receptors Translation Tumors Vaccination Vaccines
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