Engineering and Structural Characterization of a Linear Polyubiquitin-Specific Antibody

Polyubiquitination is an essential posttranslational modification that plays critical roles in cellular signaling. PolyUb (polyubiquitin) chains are formed by linking the carboxyl-terminus of one Ub (ubiquitin) subunit to either a lysine residue or the amino-terminus of an adjacent Ub. Linkage throu...

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Veröffentlicht in:	Journal of molecular biology 2012-05, Vol.418 (3-4), p.134-144
Hauptverfasser:	Matsumoto, Marissa L., Dong, Ken C., Yu, Christine, Phu, Lilian, Gao, Xinxin, Hannoush, Rami N., Hymowitz, Sarah G., Kirkpatrick, Donald S., Dixit, Vishva M., Kelley, Robert F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies - chemistry Antibodies - metabolism crystal structure Fluorescent Antibody Technique immunoglobulin Immunoglobulin Fab Fragments - chemistry Immunoglobulin Fab Fragments - metabolism Immunoprecipitation linkage lysine Models, Molecular phage display Polyubiquitin - chemistry Polyubiquitin - metabolism post-translational modification precipitin tests Protein Conformation Protein Engineering transcription factor NF-kappa B tumor necrosis factor-alpha Tumor Necrosis Factor-alpha - chemistry Tumor Necrosis Factor-alpha - metabolism ubiquitin Ubiquitination Western blotting X-ray crystallography
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