Suppressive effect of preconditioning low-frequency stimulation on subsequent induction of long-term potentiation by high frequency stimulation in hippocampal CA3 neurons

Abstract We investigated the role of inositol 1, 4, 5-trisphosphate receptors (IP3Rs), activated during preconditioning low-frequency afferent stimulation (LFS), in the subsequent induction of long-term potentiation (LTP) in CA3 neurons in hippocampal slices from mature guinea pigs. Induction of LTP...

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Veröffentlicht in:	Brain research 2012-04, Vol.1449, p.15-23
Hauptverfasser:	Yamazaki, Yoshihiko, Fujii, Satoshi, Goto, Jun-Ichi, Sugihara, Toshimichi, Sugita, Makoto, Fujiwara, Hiroki, Kaneko, Kenya, Aihara, Takeshi, Mikoshiba, Katsuhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Amino-5-phosphonovalerate - pharmacology Animals antagonists Benzoates - pharmacology Biological and medical sciences brain CA3 Region, Hippocampal - drug effects CA3 Region, Hippocampal - physiology Calcineurin Central nervous system dephosphorylation Electric Stimulation Electrophysiology Excitatory Amino Acid Antagonists - pharmacology Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology Fundamental and applied biological sciences. Psychology glutamic acid Glycine - analogs & derivatives Glycine - pharmacology Guinea Pigs Long-Term Potentiation - drug effects Long-Term Potentiation - physiology LTP induction LTP suppression Mossy Fibers, Hippocampal - drug effects Mossy Fibers, Hippocampal - physiology Mossy-fiber CA3 synapse myo-inositol Neurology neurons P3 receptor Phosphorylation - drug effects Phosphorylation - physiology Preconditioning receptors Synapses - drug effects Synapses - physiology Synaptic Transmission - drug effects Synaptic Transmission - physiology tetanus Vertebrates: nervous system and sense organs
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