High frequency of allelic loss at the BRCA1 locus in ovarian cancers: clinicopathologic and molecular associations

BRCA1 dysfunction may occur by different mechanisms that are rarely evaluated concomitantly. We aimed to analyze BRCA1 germline mutations, loss of heterozygosity (LOH) and promoter methylation in unselected ovarian carcinomas in the context of their clinicopathologic characteristics and other molecu...

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Veröffentlicht in:	Cancer genetics 2012-03, Vol.205 (3), p.94-100
Hauptverfasser:	Rzepecka, Iwona K, Szafron, Lukasz, Stys, Agnieszka, Bujko, Mateusz, Plisiecka-Halasa, Joanna, Madry, Radoslaw, Osuch, Beata, Markowska, Janina, Bidzinski, Mariusz, Kupryjanczyk, Jolanta
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Base Sequence BRCA1 germline mutations Class I Phosphatidylinositol 3-Kinases DNA Methylation Female Gene Amplification Genes, BRCA1 Germ-Line Mutation Hematology, Oncology and Palliative Medicine Humans Loss of Heterozygosity Medical Education methylation Middle Aged Ovarian Neoplasms - genetics Phosphatidylinositol 3-Kinases - genetics PIK3CA Polymorphism, Single Nucleotide Promoter Regions, Genetic Sequence Analysis, DNA TP53 Young Adult
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