Electrostatic Effects of Mutations of Ras Glutamine 61 Measured Using Vibrational Spectroscopy of a Thiocyanate Probe

Mutations of human oncoprotein p21Ras (hereafter Ras) at glutamine 61 are known to slow the rate of guanosine triphosphate (GTP) hydrolysis and transform healthy cells into malignant cells. It has been hypothesized that this glutamine plays a role in the intrinsic mechanism of GTP hydrolysis by inte...

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Veröffentlicht in:	Biochemistry (Easton) 2012-04, Vol.51 (13), p.2757-2767
Hauptverfasser:	Stafford, Amy J, Walker, David M, Webb, Lauren J
Format:	Artikel
Sprache:	eng
Schlagworte:	Glutamine - chemistry Molecular Dynamics Simulation Mutation ras Proteins - chemistry ras Proteins - genetics Spectrum Analysis - methods Static Electricity Thiocyanates - chemistry
Online-Zugang:	Volltext
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