An ultra-sensitive electrochemical sensor for ascorbic acid based on click chemistry
A highly selective and sensitive electrochemical sensor for ascorbic acid (AA) assay has been prepared through Cu(I) catalyzed azide-alkyne cycloaddition reaction (CuAAC). The catalyst, Cu(I) species, is acquired from the reduction of Cu(II) by AA in situ. In the presence of Cu(I) catalyst, the azid...
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| Veröffentlicht in: | Analyst (London) 2011-10, Vol.136 (19), p.3962-3966 |
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| creator | Qiu, Suyan Gao, Sen Xie, Lidan Chen, Hongqin Liu, Qida Lin, Zhenyu Qiu, Bin Chen, Guonan |
| description | A highly selective and sensitive electrochemical sensor for ascorbic acid (AA) assay has been prepared through Cu(I) catalyzed azide-alkyne cycloaddition reaction (CuAAC). The catalyst, Cu(I) species, is acquired from the reduction of Cu(II) by AA in situ. In the presence of Cu(I) catalyst, the azide modified Au electrode surface is shown to react quantitatively with terminal propargyl-functionalized ferrocene forming 1,2,3-triazoles. The electrochemical response of propargyl-functionalized ferrocene modified Au electrode surface can be monitored using differential pulse voltammetry (DPV) technique. Under optimal conditions, it is found that the current intensity has a linear relationship with the logarithm of AA concentration in the range of 5.0 × 10(-12) to 1.0 × 10(-9) M. Furthermore, the proposed electrochemical sensor shows a good stability (RSD 4.2%), high selectivity and low detection limit for AA detection. In addition, it also demonstrates that the proposed sensor can be applied to detect AA in real urine samples with satisfactory results. |
| doi_str_mv | 10.1039/c1an15316a |
| format | Article |
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The catalyst, Cu(I) species, is acquired from the reduction of Cu(II) by AA in situ. In the presence of Cu(I) catalyst, the azide modified Au electrode surface is shown to react quantitatively with terminal propargyl-functionalized ferrocene forming 1,2,3-triazoles. The electrochemical response of propargyl-functionalized ferrocene modified Au electrode surface can be monitored using differential pulse voltammetry (DPV) technique. Under optimal conditions, it is found that the current intensity has a linear relationship with the logarithm of AA concentration in the range of 5.0 × 10(-12) to 1.0 × 10(-9) M. Furthermore, the proposed electrochemical sensor shows a good stability (RSD 4.2%), high selectivity and low detection limit for AA detection. In addition, it also demonstrates that the proposed sensor can be applied to detect AA in real urine samples with satisfactory results.</description><identifier>ISSN: 0003-2654</identifier><identifier>EISSN: 1364-5528</identifier><identifier>DOI: 10.1039/c1an15316a</identifier><identifier>PMID: 21826289</identifier><identifier>CODEN: ANALAO</identifier><language>eng</language><publisher>Cambridge: Royal Society of Chemistry</publisher><subject>Analytical chemistry ; Ascorbic acid ; Ascorbic Acid - analysis ; Catalysts ; Chemistry ; Click Chemistry ; Cycloaddition ; Electrochemical methods ; Electrochemical Techniques - instrumentation ; Electrochemical Techniques - methods ; Electrodes ; Exact sciences and technology ; Ferrocenes ; General, instrumentation ; Gold ; Gold - chemistry ; Reduction ; Sensors ; Surface Properties</subject><ispartof>Analyst (London), 2011-10, Vol.136 (19), p.3962-3966</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c348t-e08c316f1feccdb94a0f34194e94907510d802a20eef9946ac09280d50cd7e243</citedby><cites>FETCH-LOGICAL-c348t-e08c316f1feccdb94a0f34194e94907510d802a20eef9946ac09280d50cd7e243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,2818,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24537831$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21826289$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Qiu, Suyan</creatorcontrib><creatorcontrib>Gao, Sen</creatorcontrib><creatorcontrib>Xie, Lidan</creatorcontrib><creatorcontrib>Chen, Hongqin</creatorcontrib><creatorcontrib>Liu, Qida</creatorcontrib><creatorcontrib>Lin, Zhenyu</creatorcontrib><creatorcontrib>Qiu, Bin</creatorcontrib><creatorcontrib>Chen, Guonan</creatorcontrib><title>An ultra-sensitive electrochemical sensor for ascorbic acid based on click chemistry</title><title>Analyst (London)</title><addtitle>Analyst</addtitle><description>A highly selective and sensitive electrochemical sensor for ascorbic acid (AA) assay has been prepared through Cu(I) catalyzed azide-alkyne cycloaddition reaction (CuAAC). The catalyst, Cu(I) species, is acquired from the reduction of Cu(II) by AA in situ. In the presence of Cu(I) catalyst, the azide modified Au electrode surface is shown to react quantitatively with terminal propargyl-functionalized ferrocene forming 1,2,3-triazoles. The electrochemical response of propargyl-functionalized ferrocene modified Au electrode surface can be monitored using differential pulse voltammetry (DPV) technique. Under optimal conditions, it is found that the current intensity has a linear relationship with the logarithm of AA concentration in the range of 5.0 × 10(-12) to 1.0 × 10(-9) M. Furthermore, the proposed electrochemical sensor shows a good stability (RSD 4.2%), high selectivity and low detection limit for AA detection. In addition, it also demonstrates that the proposed sensor can be applied to detect AA in real urine samples with satisfactory results.</description><subject>Analytical chemistry</subject><subject>Ascorbic acid</subject><subject>Ascorbic Acid - analysis</subject><subject>Catalysts</subject><subject>Chemistry</subject><subject>Click Chemistry</subject><subject>Cycloaddition</subject><subject>Electrochemical methods</subject><subject>Electrochemical Techniques - instrumentation</subject><subject>Electrochemical Techniques - methods</subject><subject>Electrodes</subject><subject>Exact sciences and technology</subject><subject>Ferrocenes</subject><subject>General, instrumentation</subject><subject>Gold</subject><subject>Gold - chemistry</subject><subject>Reduction</subject><subject>Sensors</subject><subject>Surface Properties</subject><issn>0003-2654</issn><issn>1364-5528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLw0AQgBdRbK1e_AGyFxGE6Owjye5Rii8oeKnnsJ3MYjRN6m4i9N-b2mqPHoZhmG8efIydC7gRoOwtCteIVInMHbCxUJlO0lSaQzYGAJXILNUjdhLj-1AKSOGYjaQwMpPGjtn8ruF93QWXRGpi1VVfxKkm7EKLb7Ss0NV802kD90O4iG1YVMgdViVfuEglbxuOdYUf_GcgdmF9yo68qyOd7fKEvT7cz6dPyezl8Xl6N0tQadMlBAaHr73whFgurHbglRZWk9UW8lRAaUA6CUTeWp05BCsNlClgmZPUasKutntXof3sKXbFcB-prl1DbR8Lmyljc2n-J43JrdYgxEBeb0kMbYyBfLEK1dKFdSGg2Ogu9roH-GK3tl8sqfxDf_0OwOUOGMy52gfXYBX3nE5VbpRQ30kEh5A</recordid><startdate>20111007</startdate><enddate>20111007</enddate><creator>Qiu, Suyan</creator><creator>Gao, Sen</creator><creator>Xie, Lidan</creator><creator>Chen, Hongqin</creator><creator>Liu, Qida</creator><creator>Lin, Zhenyu</creator><creator>Qiu, Bin</creator><creator>Chen, Guonan</creator><general>Royal Society of Chemistry</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20111007</creationdate><title>An ultra-sensitive electrochemical sensor for ascorbic acid based on click chemistry</title><author>Qiu, Suyan ; Gao, Sen ; Xie, Lidan ; Chen, Hongqin ; Liu, Qida ; Lin, Zhenyu ; Qiu, Bin ; Chen, Guonan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c348t-e08c316f1feccdb94a0f34194e94907510d802a20eef9946ac09280d50cd7e243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Analytical chemistry</topic><topic>Ascorbic acid</topic><topic>Ascorbic Acid - analysis</topic><topic>Catalysts</topic><topic>Chemistry</topic><topic>Click Chemistry</topic><topic>Cycloaddition</topic><topic>Electrochemical methods</topic><topic>Electrochemical Techniques - instrumentation</topic><topic>Electrochemical Techniques - methods</topic><topic>Electrodes</topic><topic>Exact sciences and technology</topic><topic>Ferrocenes</topic><topic>General, instrumentation</topic><topic>Gold</topic><topic>Gold - chemistry</topic><topic>Reduction</topic><topic>Sensors</topic><topic>Surface Properties</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Qiu, Suyan</creatorcontrib><creatorcontrib>Gao, Sen</creatorcontrib><creatorcontrib>Xie, Lidan</creatorcontrib><creatorcontrib>Chen, Hongqin</creatorcontrib><creatorcontrib>Liu, Qida</creatorcontrib><creatorcontrib>Lin, Zhenyu</creatorcontrib><creatorcontrib>Qiu, Bin</creatorcontrib><creatorcontrib>Chen, Guonan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Analyst (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Qiu, Suyan</au><au>Gao, Sen</au><au>Xie, Lidan</au><au>Chen, Hongqin</au><au>Liu, Qida</au><au>Lin, Zhenyu</au><au>Qiu, Bin</au><au>Chen, Guonan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An ultra-sensitive electrochemical sensor for ascorbic acid based on click chemistry</atitle><jtitle>Analyst (London)</jtitle><addtitle>Analyst</addtitle><date>2011-10-07</date><risdate>2011</risdate><volume>136</volume><issue>19</issue><spage>3962</spage><epage>3966</epage><pages>3962-3966</pages><issn>0003-2654</issn><eissn>1364-5528</eissn><coden>ANALAO</coden><abstract>A highly selective and sensitive electrochemical sensor for ascorbic acid (AA) assay has been prepared through Cu(I) catalyzed azide-alkyne cycloaddition reaction (CuAAC). The catalyst, Cu(I) species, is acquired from the reduction of Cu(II) by AA in situ. In the presence of Cu(I) catalyst, the azide modified Au electrode surface is shown to react quantitatively with terminal propargyl-functionalized ferrocene forming 1,2,3-triazoles. The electrochemical response of propargyl-functionalized ferrocene modified Au electrode surface can be monitored using differential pulse voltammetry (DPV) technique. Under optimal conditions, it is found that the current intensity has a linear relationship with the logarithm of AA concentration in the range of 5.0 × 10(-12) to 1.0 × 10(-9) M. Furthermore, the proposed electrochemical sensor shows a good stability (RSD 4.2%), high selectivity and low detection limit for AA detection. In addition, it also demonstrates that the proposed sensor can be applied to detect AA in real urine samples with satisfactory results.</abstract><cop>Cambridge</cop><pub>Royal Society of Chemistry</pub><pmid>21826289</pmid><doi>10.1039/c1an15316a</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Royal Society of Chemistry Journals Archive (1841-2007); Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Analytical chemistry Ascorbic acid Ascorbic Acid - analysis Catalysts Chemistry Click Chemistry Cycloaddition Electrochemical methods Electrochemical Techniques - instrumentation Electrochemical Techniques - methods Electrodes Exact sciences and technology Ferrocenes General, instrumentation Gold Gold - chemistry Reduction Sensors Surface Properties |
| title | An ultra-sensitive electrochemical sensor for ascorbic acid based on click chemistry |
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