Development of a negligible depletion-solid phase microextraction method to determine the free concentration of chlorpromazine in aqueous samples containing albumin

► The free concentration of compounds is influenced by the addition of proteins. ► A nd-SPME – HPLC–UV method was developed in this study. ► The developed method was used to measure the free concentration of chlorpromazine. ► The method was optimized for coating thickness and exposure time. ► Our fi...

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Veröffentlicht in:	Journal of Chromatography A 2011-11, Vol.1218 (47), p.8529-8535
Hauptverfasser:	Broeders, Jessica J.W., Blaauboer, Bas J., Hermens, Joop L.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Acrylic Resins - chemistry Albumin Albumins Animals Biocompatibility Biological and medical sciences Biomedical materials bovine serum albumin Cattle Chlorpromazine Chlorpromazine - analysis Chlorpromazine - metabolism Chromatography, High Pressure Liquid - methods coatings Culture Media - chemistry Drug Evaluation, Preclinical - standards exposure duration fouling Free concentration high performance liquid chromatography In vivo testing In vivo tests Kinetics Medical sciences microextraction nd-SPME Neuropharmacology Pharmacology. Drug treatments Protein Binding Proteins Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Serum Albumin, Bovine - chemistry Serum Albumin, Bovine - metabolism Solid Phase Microextraction - instrumentation Solid Phase Microextraction - methods Solid Phase Microextraction - standards Surgical implants
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