Enhancement of hematoporphyrin IX potential for photodynamic therapy by entrapment in silica nanospheres

The entrapment of hematoporphyrin IX (Hp IX) in silica by means of a microemulsion resulted in silica spheres of 33 ± 6 nm. The small size, narrow size distribution and lack of aggregation maintain Hp IX silica nanospheres stable in aqueous solutions for long periods and permit a detailed study of t...

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Veröffentlicht in:	Physical chemistry chemical physics : PCCP 2011-09, Vol.13 (33), p.14946-14952
Hauptverfasser:	SILVA, Paulo R, VONO, Lucas L. R, ESPOSITO, Breno P, BAPTISTA, Mauricio S, ROSSI, Liane M
Format:	Artikel
Sprache:	eng
Schlagworte:	Agglomeration Ascorbic Acid - chemistry Chemistry Colloidal state and disperse state Drugs Emulsions. Microemulsions. Foams Entrapment Exact sciences and technology Fluorescence General and physical chemistry Hematoporphyrins - chemistry Nanospheres Nanospheres - chemistry Particle Size Photochemotherapy Photodynamic therapy Photosensitizing Agents - chemistry Serum Albumin, Bovine - chemistry Silicon dioxide Silicon Dioxide - chemistry Singlet oxygen Singlet Oxygen - chemistry Surface Properties
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