Flexible casting of modular self-aligning microfluidic assembly blocks
The recent shift among developers of microfluidic technologies toward modularized "plug and play" construction reflects the steadily increasing realization that, for many would-be users of microfluidic tools, traditional clean-room microfabrication is prohibitively complex and/or expensive...
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| Veröffentlicht in: | Lab on a chip 2011-01, Vol.11 (9), p.1679-1687 |
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| container_issue | 9 |
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| container_title | Lab on a chip |
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| creator | Langelier, Sean M Livak-Dahl, Eric Manzo, Anthony J Johnson, Brian N Walter, Nils G Burns, Mark A |
| description | The recent shift among developers of microfluidic technologies toward modularized "plug and play" construction reflects the steadily increasing realization that, for many would-be users of microfluidic tools, traditional clean-room microfabrication is prohibitively complex and/or expensive. In this work, we present an advanced modular microfluidic construction scheme in which pre-fabricated microfluidic assembly blocks (MABs) can be quickly fashioned, without expertise or specialized facilities, into sophisticated microfluidic devices for a wide range of applications. Specifically, we describe three major advances to the MAB concept: (1) rapid production and extraction of MABs using flexible casting trays, (2) use of pre-coated substrates for simultaneous assembly and bonding, and (3) modification of block design to include automatic alignment and sealing structures. Finally, several exemplary applications of these MABs are demonstrated in chemical gradient synthesis, droplet generation, and total internal reflection fluorescence microscopy. |
| doi_str_mv | 10.1039/c0lc00517g |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1473-0197 |
| ispartof | Lab on a chip, 2011-01, Vol.11 (9), p.1679-1687 |
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| language | eng |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Assembly Devices Droplets Equipment Design Extraction Fluorescence Microfluidic Analytical Techniques - instrumentation Microfluidics Microscopy, Electron, Scanning Microscopy, Fluorescence Modular Trays |
| title | Flexible casting of modular self-aligning microfluidic assembly blocks |
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