Effect of vaccination against gonadotropin-releasing factor (GnRF) with Bopriva® in the prepubertal bull calf
The aim of this study was to evaluate the effect of immunization against gonadotropin-releasing factor (GnRF) with Bopriva® (Pfizer Animal Health, Parkville, Australia) in prepubertal bull calves. For the study, 6 calves were vaccinated at the age of 3 and 6 weeks with 1mL Bopriva®, and 6 animals se...
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| Veröffentlicht in: | Animal reproduction science 2012-03, Vol.131 (1-2), p.72-80 |
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| creator | Janett, F Gerig, T Tschuor, A.C Amatayakul-Chantler, S Walker, J Howard, R Piechotta, M Bollwein, H Hartnack, S Thun, R |
| description | The aim of this study was to evaluate the effect of immunization against gonadotropin-releasing factor (GnRF) with Bopriva® (Pfizer Animal Health, Parkville, Australia) in prepubertal bull calves. For the study, 6 calves were vaccinated at the age of 3 and 6 weeks with 1mL Bopriva®, and 6 animals served as matched controls. Concentrations of GnRF antibodies, testosterone and LH were determined in serum samples out to 30 weeks after the first immunization. Body weight and scrotal circumference were measured for 59 weeks. At slaughter, 65 weeks after the first immunization, the quality of epididymal sperm was evaluated. The results showed that vaccination against GnRF influenced (P |
| doi_str_mv | 10.1016/j.anireprosci.2012.02.012 |
| format | Article |
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For the study, 6 calves were vaccinated at the age of 3 and 6 weeks with 1mL Bopriva®, and 6 animals served as matched controls. Concentrations of GnRF antibodies, testosterone and LH were determined in serum samples out to 30 weeks after the first immunization. Body weight and scrotal circumference were measured for 59 weeks. At slaughter, 65 weeks after the first immunization, the quality of epididymal sperm was evaluated. The results showed that vaccination against GnRF influenced (P<0.05) anti-GnRF titer, LH and testosterone concentrations as well as scrotal circumference. Antibody titers significantly (P<0.05) increased after the booster vaccination and reached peak values 2 weeks later. Compared to control animals, inhibition (P<0.05) of the prepubertal LH secretion was observed in vaccinated calves at weeks 10 and 12–14 after the first vaccination. In vaccinated calves testosterone concentrations decreased after the booster injection to values below 0.5ng/mL serum and remained for at least 22 weeks at this low level. Animals vaccinated with Bopriva® showed a delay in testes growth and smaller scrotal circumference. Puberty occurred at the age between 46 and 55 weeks in vaccinated and between 38 and 52 weeks in control animals and body weight gain was similar in both groups. All vaccinated bulls attained spermatogenic capacity at slaughter when they were 68 weeks old.</description><identifier>ISSN: 0378-4320</identifier><identifier>EISSN: 1873-2232</identifier><identifier>DOI: 10.1016/j.anireprosci.2012.02.012</identifier><identifier>PMID: 22440457</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>animal health ; Animals ; antibodies ; Body Weight ; bulls ; Calf ; calves ; Castration ; Cattle - immunology ; GnRF ; GnRH ; Gonadotropin-Releasing Hormone - antagonists & inhibitors ; Gonadotropin-Releasing Hormone - immunology ; luteinizing hormone ; Luteinizing Hormone - blood ; Male ; Organ Size ; Puberty ; Random Allocation ; Scrotum - immunology ; secretion ; Sexual Maturation - physiology ; slaughter ; spermatozoa ; Statistics, Nonparametric ; testes ; Testis - immunology ; testosterone ; Testosterone - blood ; vaccination ; Vaccination - methods ; Vaccination - veterinary ; Vaccine ; weight gain</subject><ispartof>Animal reproduction science, 2012-03, Vol.131 (1-2), p.72-80</ispartof><rights>2012 Elsevier B.V.</rights><rights>Copyright © 2012 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c531t-5ca7200764343af02b9b1c2ddafe20b15805f91d3393a4d6ea6f60c7a88f757e3</citedby><cites>FETCH-LOGICAL-c531t-5ca7200764343af02b9b1c2ddafe20b15805f91d3393a4d6ea6f60c7a88f757e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.anireprosci.2012.02.012$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22440457$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Janett, F</creatorcontrib><creatorcontrib>Gerig, T</creatorcontrib><creatorcontrib>Tschuor, A.C</creatorcontrib><creatorcontrib>Amatayakul-Chantler, S</creatorcontrib><creatorcontrib>Walker, J</creatorcontrib><creatorcontrib>Howard, R</creatorcontrib><creatorcontrib>Piechotta, M</creatorcontrib><creatorcontrib>Bollwein, H</creatorcontrib><creatorcontrib>Hartnack, S</creatorcontrib><creatorcontrib>Thun, R</creatorcontrib><title>Effect of vaccination against gonadotropin-releasing factor (GnRF) with Bopriva® in the prepubertal bull calf</title><title>Animal reproduction science</title><addtitle>Anim Reprod Sci</addtitle><description>The aim of this study was to evaluate the effect of immunization against gonadotropin-releasing factor (GnRF) with Bopriva® (Pfizer Animal Health, Parkville, Australia) in prepubertal bull calves. For the study, 6 calves were vaccinated at the age of 3 and 6 weeks with 1mL Bopriva®, and 6 animals served as matched controls. Concentrations of GnRF antibodies, testosterone and LH were determined in serum samples out to 30 weeks after the first immunization. Body weight and scrotal circumference were measured for 59 weeks. At slaughter, 65 weeks after the first immunization, the quality of epididymal sperm was evaluated. The results showed that vaccination against GnRF influenced (P<0.05) anti-GnRF titer, LH and testosterone concentrations as well as scrotal circumference. Antibody titers significantly (P<0.05) increased after the booster vaccination and reached peak values 2 weeks later. Compared to control animals, inhibition (P<0.05) of the prepubertal LH secretion was observed in vaccinated calves at weeks 10 and 12–14 after the first vaccination. In vaccinated calves testosterone concentrations decreased after the booster injection to values below 0.5ng/mL serum and remained for at least 22 weeks at this low level. Animals vaccinated with Bopriva® showed a delay in testes growth and smaller scrotal circumference. Puberty occurred at the age between 46 and 55 weeks in vaccinated and between 38 and 52 weeks in control animals and body weight gain was similar in both groups. All vaccinated bulls attained spermatogenic capacity at slaughter when they were 68 weeks old.</description><subject>animal health</subject><subject>Animals</subject><subject>antibodies</subject><subject>Body Weight</subject><subject>bulls</subject><subject>Calf</subject><subject>calves</subject><subject>Castration</subject><subject>Cattle - immunology</subject><subject>GnRF</subject><subject>GnRH</subject><subject>Gonadotropin-Releasing Hormone - antagonists & inhibitors</subject><subject>Gonadotropin-Releasing Hormone - immunology</subject><subject>luteinizing hormone</subject><subject>Luteinizing Hormone - blood</subject><subject>Male</subject><subject>Organ Size</subject><subject>Puberty</subject><subject>Random Allocation</subject><subject>Scrotum - immunology</subject><subject>secretion</subject><subject>Sexual Maturation - physiology</subject><subject>slaughter</subject><subject>spermatozoa</subject><subject>Statistics, Nonparametric</subject><subject>testes</subject><subject>Testis - immunology</subject><subject>testosterone</subject><subject>Testosterone - blood</subject><subject>vaccination</subject><subject>Vaccination - methods</subject><subject>Vaccination - veterinary</subject><subject>Vaccine</subject><subject>weight gain</subject><issn>0378-4320</issn><issn>1873-2232</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc9uEzEQhy0EoqHwCmBOwGGD_-1691iitiBVQgJ6tma949TRxg62E8RL8RA8GY5SECeENNJcvpn5-TMhLzlbcsa7t5slBJ9wl2K2fikYF0tWi4sHZMF7LRshpHhIFkzqvlFSsDPyJOcNY0x33fCYnAmhFFOtXpBw6RzaQqOjB7DWByg-Bgpr8CEXuo4BplhS3PnQJJwRsg9r6sCWmOjr6_Dp6g395ssdfRd3yR_g5w_qAy13SHc14H7EVGCm436eqYXZPSWPHMwZn933c3J7dfll9b65-Xj9YXVx09hW8tK0FrQ4plVSSXBMjMPIrZgmcCjYyNuetW7gk5SDBDV1CJ3rmNXQ9063GuU5eXXaWx193WMuZuuzxXmGgHGfzdDJXirNukoOJ9JWmzmhM_UdW0jfDWfmaNtszF-2zdG2YbW4qLPP76_sxy1OfyZ_663AixPgIBpYJ5_N7ee6QdWvUK2sGf5FCM2GI7E6EVh9HTwmU2NgsDjVULaYKfr_iPoLGbSqwA</recordid><startdate>20120301</startdate><enddate>20120301</enddate><creator>Janett, F</creator><creator>Gerig, T</creator><creator>Tschuor, A.C</creator><creator>Amatayakul-Chantler, S</creator><creator>Walker, J</creator><creator>Howard, R</creator><creator>Piechotta, M</creator><creator>Bollwein, H</creator><creator>Hartnack, S</creator><creator>Thun, R</creator><general>Elsevier B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120301</creationdate><title>Effect of vaccination against gonadotropin-releasing factor (GnRF) with Bopriva® in the prepubertal bull calf</title><author>Janett, F ; Gerig, T ; Tschuor, A.C ; Amatayakul-Chantler, S ; Walker, J ; Howard, R ; Piechotta, M ; Bollwein, H ; Hartnack, S ; Thun, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c531t-5ca7200764343af02b9b1c2ddafe20b15805f91d3393a4d6ea6f60c7a88f757e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>animal health</topic><topic>Animals</topic><topic>antibodies</topic><topic>Body Weight</topic><topic>bulls</topic><topic>Calf</topic><topic>calves</topic><topic>Castration</topic><topic>Cattle - immunology</topic><topic>GnRF</topic><topic>GnRH</topic><topic>Gonadotropin-Releasing Hormone - antagonists & inhibitors</topic><topic>Gonadotropin-Releasing Hormone - immunology</topic><topic>luteinizing hormone</topic><topic>Luteinizing Hormone - blood</topic><topic>Male</topic><topic>Organ Size</topic><topic>Puberty</topic><topic>Random Allocation</topic><topic>Scrotum - immunology</topic><topic>secretion</topic><topic>Sexual Maturation - physiology</topic><topic>slaughter</topic><topic>spermatozoa</topic><topic>Statistics, Nonparametric</topic><topic>testes</topic><topic>Testis - immunology</topic><topic>testosterone</topic><topic>Testosterone - blood</topic><topic>vaccination</topic><topic>Vaccination - methods</topic><topic>Vaccination - veterinary</topic><topic>Vaccine</topic><topic>weight gain</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Janett, F</creatorcontrib><creatorcontrib>Gerig, T</creatorcontrib><creatorcontrib>Tschuor, A.C</creatorcontrib><creatorcontrib>Amatayakul-Chantler, S</creatorcontrib><creatorcontrib>Walker, J</creatorcontrib><creatorcontrib>Howard, R</creatorcontrib><creatorcontrib>Piechotta, M</creatorcontrib><creatorcontrib>Bollwein, H</creatorcontrib><creatorcontrib>Hartnack, S</creatorcontrib><creatorcontrib>Thun, R</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Animal reproduction science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Janett, F</au><au>Gerig, T</au><au>Tschuor, A.C</au><au>Amatayakul-Chantler, S</au><au>Walker, J</au><au>Howard, R</au><au>Piechotta, M</au><au>Bollwein, H</au><au>Hartnack, S</au><au>Thun, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of vaccination against gonadotropin-releasing factor (GnRF) with Bopriva® in the prepubertal bull calf</atitle><jtitle>Animal reproduction science</jtitle><addtitle>Anim Reprod Sci</addtitle><date>2012-03-01</date><risdate>2012</risdate><volume>131</volume><issue>1-2</issue><spage>72</spage><epage>80</epage><pages>72-80</pages><issn>0378-4320</issn><eissn>1873-2232</eissn><abstract>The aim of this study was to evaluate the effect of immunization against gonadotropin-releasing factor (GnRF) with Bopriva® (Pfizer Animal Health, Parkville, Australia) in prepubertal bull calves. For the study, 6 calves were vaccinated at the age of 3 and 6 weeks with 1mL Bopriva®, and 6 animals served as matched controls. Concentrations of GnRF antibodies, testosterone and LH were determined in serum samples out to 30 weeks after the first immunization. Body weight and scrotal circumference were measured for 59 weeks. At slaughter, 65 weeks after the first immunization, the quality of epididymal sperm was evaluated. The results showed that vaccination against GnRF influenced (P<0.05) anti-GnRF titer, LH and testosterone concentrations as well as scrotal circumference. Antibody titers significantly (P<0.05) increased after the booster vaccination and reached peak values 2 weeks later. Compared to control animals, inhibition (P<0.05) of the prepubertal LH secretion was observed in vaccinated calves at weeks 10 and 12–14 after the first vaccination. In vaccinated calves testosterone concentrations decreased after the booster injection to values below 0.5ng/mL serum and remained for at least 22 weeks at this low level. Animals vaccinated with Bopriva® showed a delay in testes growth and smaller scrotal circumference. Puberty occurred at the age between 46 and 55 weeks in vaccinated and between 38 and 52 weeks in control animals and body weight gain was similar in both groups. All vaccinated bulls attained spermatogenic capacity at slaughter when they were 68 weeks old.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>22440457</pmid><doi>10.1016/j.anireprosci.2012.02.012</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0378-4320 |
| ispartof | Animal reproduction science, 2012-03, Vol.131 (1-2), p.72-80 |
| issn | 0378-4320 1873-2232 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | animal health Animals antibodies Body Weight bulls Calf calves Castration Cattle - immunology GnRF GnRH Gonadotropin-Releasing Hormone - antagonists & inhibitors Gonadotropin-Releasing Hormone - immunology luteinizing hormone Luteinizing Hormone - blood Male Organ Size Puberty Random Allocation Scrotum - immunology secretion Sexual Maturation - physiology slaughter spermatozoa Statistics, Nonparametric testes Testis - immunology testosterone Testosterone - blood vaccination Vaccination - methods Vaccination - veterinary Vaccine weight gain |
| title | Effect of vaccination against gonadotropin-releasing factor (GnRF) with Bopriva® in the prepubertal bull calf |
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