Re-circulation of lymphocytes mediated by sphingosine-1-phosphate receptor-1 contributes to resistance against experimental infection with the protozoan parasite Trypanosoma cruzi

Highlights ► We detected specific CD8+ T cells to Trypanosoma cruzi after infection. ► Specific CD8+ T cells are primed in the draining lymph nodes. ► We administered the functional antagonist of S1P1 (FTY-720) prior to infection. ► FTY-720 administration reduced re-circulation of specific CD8+ T ce...

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Veröffentlicht in:	Vaccine 2012-04, Vol.30 (18), p.2882-2891
Hauptverfasser:	Dominguez, Mariana R, Ersching, Jonatan, Lemos, Ramon, Machado, Alexandre V, Bruna-Romero, Oscar, Rodrigues, Mauricio M, de Vasconcelos, José Ronnie C
Format:	Artikel
Sprache:	eng
Schlagworte:	adaptive immunity Allergy and Immunology Animals CD11c Antigen - analysis CD8 CD8 antigen CD8-positive T-lymphocytes CD8-Positive T-Lymphocytes - chemistry CD8-Positive T-Lymphocytes - immunology Epitopes Experimental infection Female FTY720 Gene-based vaccines human diseases immune response Immunity Lymph nodes Lymph Nodes - immunology Lymphocytes T Mice Mice, Inbred C57BL Mortality parasitemia parasites Protozoan Receptors, Lysosphingolipid - metabolism Sphingosine 1-phosphate Spleen Spleen - immunology Trypanosoma cruzi Trypanosoma cruzi - immunology Vaccination Vaccines
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