Pseudoangiomatous Stromal Hyperplasia (PASH) of the Breast: A Clinicopathological Study of 79 Cases
Background. Pseudoangiomatous stromal hyperplasia (PASH) of the breast is a benign lesion that can present as a palpable nodule or as an incidental finding in breast biopsies. Design. The study comprised 79 cases diagnosed at Loyola University Medical Center from 2002 to 2009. The pathology slides w...
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| Veröffentlicht in: | International journal of surgical pathology 2012-02, Vol.20 (1), p.54-58 |
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| container_title | International journal of surgical pathology |
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| creator | Drinka, Eva K. Bargaje, Archana Erşahin, Çağatay H. Patel, Priya Salhadar, Alia Sinacore, James Rajan, Prabha |
| description | Background. Pseudoangiomatous stromal hyperplasia (PASH) of the breast is a benign lesion that can present as a palpable nodule or as an incidental finding in breast biopsies. Design. The study comprised 79 cases diagnosed at Loyola University Medical Center from 2002 to 2009. The pathology slides were reviewed to document the distribution, type, and association with preneoplastic or neoplastic epithelial lesions. Z-test for independent proportions is used for analysis. Results. A total of 76 patients were female and 3 were male. In all, 59.8% of patients presented with a breast mass and in 40.2% the lesion was an incidental finding. Classical PASH morphology was seen in 97.6% and proliferative PASH in 2.4%. Associated epithelial lesions were benign proliferative changes in 60.4%, atypical ductal and atypical lobular hyperplasia in 25.6% and infiltrating carcinoma in 11% of cases. Conclusions. Based on these results, extensive sampling of biopsy specimen with PASH and appropriate clinical and radiologic follow-up is recommended. |
| doi_str_mv | 10.1177/1066896911418643 |
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Pseudoangiomatous stromal hyperplasia (PASH) of the breast is a benign lesion that can present as a palpable nodule or as an incidental finding in breast biopsies. Design. The study comprised 79 cases diagnosed at Loyola University Medical Center from 2002 to 2009. The pathology slides were reviewed to document the distribution, type, and association with preneoplastic or neoplastic epithelial lesions. Z-test for independent proportions is used for analysis. Results. A total of 76 patients were female and 3 were male. In all, 59.8% of patients presented with a breast mass and in 40.2% the lesion was an incidental finding. Classical PASH morphology was seen in 97.6% and proliferative PASH in 2.4%. Associated epithelial lesions were benign proliferative changes in 60.4%, atypical ductal and atypical lobular hyperplasia in 25.6% and infiltrating carcinoma in 11% of cases. Conclusions. Based on these results, extensive sampling of biopsy specimen with PASH and appropriate clinical and radiologic follow-up is recommended.</description><identifier>ISSN: 1066-8969</identifier><identifier>EISSN: 1940-2465</identifier><identifier>DOI: 10.1177/1066896911418643</identifier><identifier>PMID: 21862488</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Adult ; Angiomatosis - complications ; Angiomatosis - pathology ; Breast Diseases - complications ; Breast Diseases - pathology ; Carcinoma - complications ; Carcinoma - pathology ; Female ; Humans ; Hyperplasia - complications ; Hyperplasia - pathology ; Male ; Retrospective Studies</subject><ispartof>International journal of surgical pathology, 2012-02, Vol.20 (1), p.54-58</ispartof><rights>The Author(s) 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c289t-f6189f9e63fc53f29af75cb428c82b4b27849cdb4f258d4cb46e975305f79c9c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/1066896911418643$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/1066896911418643$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21862488$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Drinka, Eva K.</creatorcontrib><creatorcontrib>Bargaje, Archana</creatorcontrib><creatorcontrib>Erşahin, Çağatay H.</creatorcontrib><creatorcontrib>Patel, Priya</creatorcontrib><creatorcontrib>Salhadar, Alia</creatorcontrib><creatorcontrib>Sinacore, James</creatorcontrib><creatorcontrib>Rajan, Prabha</creatorcontrib><title>Pseudoangiomatous Stromal Hyperplasia (PASH) of the Breast: A Clinicopathological Study of 79 Cases</title><title>International journal of surgical pathology</title><addtitle>Int J Surg Pathol</addtitle><description>Background. Pseudoangiomatous stromal hyperplasia (PASH) of the breast is a benign lesion that can present as a palpable nodule or as an incidental finding in breast biopsies. Design. The study comprised 79 cases diagnosed at Loyola University Medical Center from 2002 to 2009. The pathology slides were reviewed to document the distribution, type, and association with preneoplastic or neoplastic epithelial lesions. Z-test for independent proportions is used for analysis. Results. A total of 76 patients were female and 3 were male. In all, 59.8% of patients presented with a breast mass and in 40.2% the lesion was an incidental finding. Classical PASH morphology was seen in 97.6% and proliferative PASH in 2.4%. Associated epithelial lesions were benign proliferative changes in 60.4%, atypical ductal and atypical lobular hyperplasia in 25.6% and infiltrating carcinoma in 11% of cases. Conclusions. Based on these results, extensive sampling of biopsy specimen with PASH and appropriate clinical and radiologic follow-up is recommended.</description><subject>Adult</subject><subject>Angiomatosis - complications</subject><subject>Angiomatosis - pathology</subject><subject>Breast Diseases - complications</subject><subject>Breast Diseases - pathology</subject><subject>Carcinoma - complications</subject><subject>Carcinoma - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Hyperplasia - complications</subject><subject>Hyperplasia - pathology</subject><subject>Male</subject><subject>Retrospective Studies</subject><issn>1066-8969</issn><issn>1940-2465</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kL1PwzAQxS0EoqWwM6FswBDwVxybrVRAkSpRqTBbjmOXVEkd7GTof4-rFAYkpnvS-93T3QPgEsE7hPL8HkHGuGACIYo4o-QIjJGgMMWUZcdRRzvd-yNwFsIGQogZRqdghCONKedj8LAMpi-d2q4r16jO9SFZdT7KOpnvWuPbWoVKJTfL6Wp-mzibdJ8mefRGhe4cnFhVB3NxmBPw8fz0Ppuni7eX19l0kWrMRZdahriwwjBidUYsFsrmmS4o5prjghY451TosqAWZ7yk0WFG5BmBmc2FFppMwPWQ23r31ZvQyaYK2tS12pp4rxSMcBILwJGEA6m9C8EbK1tfNcrvJIJyX5j8W1hcuTqE90Vjyt-Fn4YikA5AUGsjN6732_js_4Hf1lNxRg</recordid><startdate>201202</startdate><enddate>201202</enddate><creator>Drinka, Eva K.</creator><creator>Bargaje, Archana</creator><creator>Erşahin, Çağatay H.</creator><creator>Patel, Priya</creator><creator>Salhadar, Alia</creator><creator>Sinacore, James</creator><creator>Rajan, Prabha</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201202</creationdate><title>Pseudoangiomatous Stromal Hyperplasia (PASH) of the Breast</title><author>Drinka, Eva K. ; Bargaje, Archana ; Erşahin, Çağatay H. ; Patel, Priya ; Salhadar, Alia ; Sinacore, James ; Rajan, Prabha</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c289t-f6189f9e63fc53f29af75cb428c82b4b27849cdb4f258d4cb46e975305f79c9c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Angiomatosis - complications</topic><topic>Angiomatosis - pathology</topic><topic>Breast Diseases - complications</topic><topic>Breast Diseases - pathology</topic><topic>Carcinoma - complications</topic><topic>Carcinoma - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Hyperplasia - complications</topic><topic>Hyperplasia - pathology</topic><topic>Male</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Drinka, Eva K.</creatorcontrib><creatorcontrib>Bargaje, Archana</creatorcontrib><creatorcontrib>Erşahin, Çağatay H.</creatorcontrib><creatorcontrib>Patel, Priya</creatorcontrib><creatorcontrib>Salhadar, Alia</creatorcontrib><creatorcontrib>Sinacore, James</creatorcontrib><creatorcontrib>Rajan, Prabha</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of surgical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Drinka, Eva K.</au><au>Bargaje, Archana</au><au>Erşahin, Çağatay H.</au><au>Patel, Priya</au><au>Salhadar, Alia</au><au>Sinacore, James</au><au>Rajan, Prabha</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pseudoangiomatous Stromal Hyperplasia (PASH) of the Breast: A Clinicopathological Study of 79 Cases</atitle><jtitle>International journal of surgical pathology</jtitle><addtitle>Int J Surg Pathol</addtitle><date>2012-02</date><risdate>2012</risdate><volume>20</volume><issue>1</issue><spage>54</spage><epage>58</epage><pages>54-58</pages><issn>1066-8969</issn><eissn>1940-2465</eissn><abstract>Background. Pseudoangiomatous stromal hyperplasia (PASH) of the breast is a benign lesion that can present as a palpable nodule or as an incidental finding in breast biopsies. Design. The study comprised 79 cases diagnosed at Loyola University Medical Center from 2002 to 2009. The pathology slides were reviewed to document the distribution, type, and association with preneoplastic or neoplastic epithelial lesions. Z-test for independent proportions is used for analysis. Results. A total of 76 patients were female and 3 were male. In all, 59.8% of patients presented with a breast mass and in 40.2% the lesion was an incidental finding. Classical PASH morphology was seen in 97.6% and proliferative PASH in 2.4%. Associated epithelial lesions were benign proliferative changes in 60.4%, atypical ductal and atypical lobular hyperplasia in 25.6% and infiltrating carcinoma in 11% of cases. Conclusions. Based on these results, extensive sampling of biopsy specimen with PASH and appropriate clinical and radiologic follow-up is recommended.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>21862488</pmid><doi>10.1177/1066896911418643</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Angiomatosis - complications Angiomatosis - pathology Breast Diseases - complications Breast Diseases - pathology Carcinoma - complications Carcinoma - pathology Female Humans Hyperplasia - complications Hyperplasia - pathology Male Retrospective Studies |
| title | Pseudoangiomatous Stromal Hyperplasia (PASH) of the Breast: A Clinicopathological Study of 79 Cases |
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