Comparison of cytokine profiles in bronchoalveolar lavage fluid of mice exposed to respiratory and contact sensitizers

Respiratory sensitization to certain low molecular weight chemicals is a big concern for workers, but unfortunately there are no validated animal models to allow identification of sensitizing chemicals in the environment. In the present study, dermally sensitized and intratracheally challenged mice...

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Veröffentlicht in:	Journal of toxicological sciences 2012/04/01, Vol.37(2), pp.337-343
Hauptverfasser:	Mori, Takashi, Tanimoto, Yoshiharu, Ota, Mika, Masakado, Takaomi, Kitamoto, Sachiko, Saito, Koichi, Isobe, Naohiko, Kaneko, Hideo
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergens - toxicity Alveoli Animals Bronchoalveolar lavage fluid Bronchoalveolar Lavage Fluid - immunology Contact sensitizer Cytokines Cytokines - immunology Dermal sensitization Disease Models, Animal Female Immunoglobulin E - blood Intratracheal challenge Mice Mice, Inbred BALB C Respiratory Hypersensitivity - blood Respiratory Hypersensitivity - chemically induced Respiratory Hypersensitivity - immunology Respiratory sensitizer
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