"Possible Primary Antiphospholipid Syndrome" with Concurrent Diffuse Alveolar Hemorrhaging and Libman-Sacks Endocarditis Mimicking Catastrophic Antiphospholipid Syndrome
Although antiphospholipid antibody syndrome (APS) is an autoimmune condition that is primarily characterized by arterial or venous thrombosis or pregnancy morbidity and the presence of antiphospholipid antibodies (aPL), recent reviews have introduced non-thromboembolic manifestations. We describe th...
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| Veröffentlicht in: | Internal Medicine 2012, Vol.51(7), pp.813-816 |
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| container_title | Internal Medicine |
| container_volume | 51 |
| creator | Suzuki, Akitake Asazuma, Naoki Kikuchi, Eigo Kawanobe, Takeshi Horimoto, Yoshihiko Yokobari, Ryuichi Kotake, Shigeru Okai, Takahiro |
| description | Although antiphospholipid antibody syndrome (APS) is an autoimmune condition that is primarily characterized by arterial or venous thrombosis or pregnancy morbidity and the presence of antiphospholipid antibodies (aPL), recent reviews have introduced non-thromboembolic manifestations. We describe the case of a 58-year-old woman with vegetation on the aortic valve, whose initial presentation of APS abruptly developed into diffuse pulmonary hemorrhage. Despite consecutive plasma exchange procedures and the administration of corticosteroids and high-dose intravenous immunoglobulin, multiple brain infarctions developed, and the patient died of pneumonia. Although anecdotal, this case might serve as a useful example of the non-standard complications of fulminant APS. |
| doi_str_mv | 10.2169/internalmedicine.51.6592 |
| format | Article |
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We describe the case of a 58-year-old woman with vegetation on the aortic valve, whose initial presentation of APS abruptly developed into diffuse pulmonary hemorrhage. Despite consecutive plasma exchange procedures and the administration of corticosteroids and high-dose intravenous immunoglobulin, multiple brain infarctions developed, and the patient died of pneumonia. Although anecdotal, this case might serve as a useful example of the non-standard complications of fulminant APS.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.51.6592</identifier><identifier>PMID: 22466846</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>Alveoli ; antiphospholipid antibodies ; antiphospholipid syndrome ; Antiphospholipid Syndrome - complications ; Antiphospholipid Syndrome - diagnosis ; Aortic valve ; Autoimmune diseases ; Brain ; catastrophic antiphospholipid syndrome ; Cerebral infarction ; Corticoids ; Diagnosis, Differential ; diffuse alveolar hemorrhage ; Endocarditis ; Endocarditis - complications ; Fatal Outcome ; Female ; Hemorrhage ; Hemorrhage - complications ; Humans ; Immunoglobulins ; Intravenous administration ; Libman-Sacks endocarditis ; Lung ; Lung Diseases - complications ; Lupus Erythematosus, Systemic - complications ; Middle Aged ; Mimicry ; Morbidity ; multiple brain infarctions ; Pneumonia ; Pregnancy ; Thrombosis ; Vegetation</subject><ispartof>Internal Medicine, 2012, Vol.51(7), pp.813-816</ispartof><rights>2012 by The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c556t-89843440155fd5e3ac907372c9aa8509974f0f488a60c6f511b423d301fd71aa3</citedby><cites>FETCH-LOGICAL-c556t-89843440155fd5e3ac907372c9aa8509974f0f488a60c6f511b423d301fd71aa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22466846$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Suzuki, Akitake</creatorcontrib><creatorcontrib>Asazuma, Naoki</creatorcontrib><creatorcontrib>Kikuchi, Eigo</creatorcontrib><creatorcontrib>Kawanobe, Takeshi</creatorcontrib><creatorcontrib>Horimoto, Yoshihiko</creatorcontrib><creatorcontrib>Yokobari, Ryuichi</creatorcontrib><creatorcontrib>Kotake, Shigeru</creatorcontrib><creatorcontrib>Okai, Takahiro</creatorcontrib><title>"Possible Primary Antiphospholipid Syndrome" with Concurrent Diffuse Alveolar Hemorrhaging and Libman-Sacks Endocarditis Mimicking Catastrophic Antiphospholipid Syndrome</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>Although antiphospholipid antibody syndrome (APS) is an autoimmune condition that is primarily characterized by arterial or venous thrombosis or pregnancy morbidity and the presence of antiphospholipid antibodies (aPL), recent reviews have introduced non-thromboembolic manifestations. We describe the case of a 58-year-old woman with vegetation on the aortic valve, whose initial presentation of APS abruptly developed into diffuse pulmonary hemorrhage. Despite consecutive plasma exchange procedures and the administration of corticosteroids and high-dose intravenous immunoglobulin, multiple brain infarctions developed, and the patient died of pneumonia. Although anecdotal, this case might serve as a useful example of the non-standard complications of fulminant APS.</description><subject>Alveoli</subject><subject>antiphospholipid antibodies</subject><subject>antiphospholipid syndrome</subject><subject>Antiphospholipid Syndrome - complications</subject><subject>Antiphospholipid Syndrome - diagnosis</subject><subject>Aortic valve</subject><subject>Autoimmune diseases</subject><subject>Brain</subject><subject>catastrophic antiphospholipid syndrome</subject><subject>Cerebral infarction</subject><subject>Corticoids</subject><subject>Diagnosis, Differential</subject><subject>diffuse alveolar hemorrhage</subject><subject>Endocarditis</subject><subject>Endocarditis - complications</subject><subject>Fatal Outcome</subject><subject>Female</subject><subject>Hemorrhage</subject><subject>Hemorrhage - complications</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Intravenous administration</subject><subject>Libman-Sacks endocarditis</subject><subject>Lung</subject><subject>Lung Diseases - complications</subject><subject>Lupus Erythematosus, Systemic - complications</subject><subject>Middle Aged</subject><subject>Mimicry</subject><subject>Morbidity</subject><subject>multiple brain infarctions</subject><subject>Pneumonia</subject><subject>Pregnancy</subject><subject>Thrombosis</subject><subject>Vegetation</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1v1DAQhi0EokvhLyCrF7hk8Uec2MfVtlCkRVQqnKNZx9m4TexgO6D-JP4lXqXsAQGHmTnMMx96X4QwJWtGK_XOumSCg2E0rdXWmbWg60oo9gStKC9VUTMunqIVUVQWLKcz9CLGO0K4rBV7js4YK6tKltUK_by48THa_WDwTbAjhAe8cclOvY85BjvZFt8-uDb40VzgHzb1eOudnkMwLuFL23VzNHgzfDd-gICvzehD6OFg3QGDa_HO7kdwxS3o-4ivXOs1hNYmG_EnO1p9f-S2kCCm4Kfe6n9ff4medTBE8-qxnqOv76--bK-L3ecPH7ebXaGFqFIhlSx5WRIqRNcKw0ErUvOaaQUgBVGqLjvSlVJCRXTVCUr3JeMtJ7RrawrAz9GbZe8U_LfZxNSMNmozDOCMn2OjKi45YUxk8u1_SZr1FkecZlQuqA5Z7mC6ZlrUzlBztLT509JG0OZoaR59_Xhl3ufmafC3hxnYLcBdTHAwJwBCsnowf91cLyl_dsJ0D6Exjv8CNzrCsQ</recordid><startdate>20120101</startdate><enddate>20120101</enddate><creator>Suzuki, Akitake</creator><creator>Asazuma, Naoki</creator><creator>Kikuchi, Eigo</creator><creator>Kawanobe, Takeshi</creator><creator>Horimoto, Yoshihiko</creator><creator>Yokobari, Ryuichi</creator><creator>Kotake, Shigeru</creator><creator>Okai, Takahiro</creator><general>The Japanese Society of Internal Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20120101</creationdate><title>"Possible Primary Antiphospholipid Syndrome" with Concurrent Diffuse Alveolar Hemorrhaging and Libman-Sacks Endocarditis Mimicking Catastrophic Antiphospholipid Syndrome</title><author>Suzuki, Akitake ; Asazuma, Naoki ; Kikuchi, Eigo ; Kawanobe, Takeshi ; Horimoto, Yoshihiko ; Yokobari, Ryuichi ; Kotake, Shigeru ; Okai, Takahiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c556t-89843440155fd5e3ac907372c9aa8509974f0f488a60c6f511b423d301fd71aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Alveoli</topic><topic>antiphospholipid antibodies</topic><topic>antiphospholipid syndrome</topic><topic>Antiphospholipid Syndrome - complications</topic><topic>Antiphospholipid Syndrome - diagnosis</topic><topic>Aortic valve</topic><topic>Autoimmune diseases</topic><topic>Brain</topic><topic>catastrophic antiphospholipid syndrome</topic><topic>Cerebral infarction</topic><topic>Corticoids</topic><topic>Diagnosis, Differential</topic><topic>diffuse alveolar hemorrhage</topic><topic>Endocarditis</topic><topic>Endocarditis - complications</topic><topic>Fatal Outcome</topic><topic>Female</topic><topic>Hemorrhage</topic><topic>Hemorrhage - complications</topic><topic>Humans</topic><topic>Immunoglobulins</topic><topic>Intravenous administration</topic><topic>Libman-Sacks endocarditis</topic><topic>Lung</topic><topic>Lung Diseases - complications</topic><topic>Lupus Erythematosus, Systemic - complications</topic><topic>Middle Aged</topic><topic>Mimicry</topic><topic>Morbidity</topic><topic>multiple brain infarctions</topic><topic>Pneumonia</topic><topic>Pregnancy</topic><topic>Thrombosis</topic><topic>Vegetation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Suzuki, Akitake</creatorcontrib><creatorcontrib>Asazuma, Naoki</creatorcontrib><creatorcontrib>Kikuchi, Eigo</creatorcontrib><creatorcontrib>Kawanobe, Takeshi</creatorcontrib><creatorcontrib>Horimoto, Yoshihiko</creatorcontrib><creatorcontrib>Yokobari, Ryuichi</creatorcontrib><creatorcontrib>Kotake, Shigeru</creatorcontrib><creatorcontrib>Okai, Takahiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Suzuki, Akitake</au><au>Asazuma, Naoki</au><au>Kikuchi, Eigo</au><au>Kawanobe, Takeshi</au><au>Horimoto, Yoshihiko</au><au>Yokobari, Ryuichi</au><au>Kotake, Shigeru</au><au>Okai, Takahiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>"Possible Primary Antiphospholipid Syndrome" with Concurrent Diffuse Alveolar Hemorrhaging and Libman-Sacks Endocarditis Mimicking Catastrophic Antiphospholipid Syndrome</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. 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| subjects | Alveoli antiphospholipid antibodies antiphospholipid syndrome Antiphospholipid Syndrome - complications Antiphospholipid Syndrome - diagnosis Aortic valve Autoimmune diseases Brain catastrophic antiphospholipid syndrome Cerebral infarction Corticoids Diagnosis, Differential diffuse alveolar hemorrhage Endocarditis Endocarditis - complications Fatal Outcome Female Hemorrhage Hemorrhage - complications Humans Immunoglobulins Intravenous administration Libman-Sacks endocarditis Lung Lung Diseases - complications Lupus Erythematosus, Systemic - complications Middle Aged Mimicry Morbidity multiple brain infarctions Pneumonia Pregnancy Thrombosis Vegetation |
| title | "Possible Primary Antiphospholipid Syndrome" with Concurrent Diffuse Alveolar Hemorrhaging and Libman-Sacks Endocarditis Mimicking Catastrophic Antiphospholipid Syndrome |
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