Controlled delivery of nanosuspensions from osmotic pumps: Zero order and non-zero order kinetics

Nanosuspensions have gained great interest in the last decade as a formulation tool for poorly soluble drugs. By decreasing particle sizes nanosuspensions enhance dissolution rate and bioavailability of the active pharmaceutical ingredient. Micro-osmotic pumps are widely used in experimental pharmac...

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Veröffentlicht in:	Journal of controlled release 2012-03, Vol.158 (3), p.403-412
Hauptverfasser:	Hill, Alexandra, Geißler, Simon, Weigandt, Markus, Mäder, Karsten
Format:	Artikel
Sprache:	eng
Schlagworte:	animals Antihypertensive Agents - chemistry bioavailability Biological and medical sciences Burst release Captopril - chemistry Coloring Agents - chemistry Delayed-Action Preparations - chemistry drugs Fenofibrate - chemistry fluorescein Fluorescein - chemistry General pharmacology high performance liquid chromatography Hypolipidemic Agents - chemistry Infusion Pumps, Implantable ingredients Kinetics Medical sciences methylene blue Methylene Blue - chemistry Nanosuspension osmolality Osmosis Osmotic pumps Particle Size Pharmaceutical technology. Pharmaceutical industry pharmacology Pharmacology. Drug treatments Preclinical development Pump position pumps sodium sodium chloride Suspensions Viscosity
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