Effect of the Anchor in Polyethylene Glycol-Lipids on the Transfection Activity of PEGylated Cationic Liposomes Encapsulating DNA

The use of polyethylene glycol (PEG)-modified lipids (PEG-lipids) as a component of cationic liposomes impairs the cytoplasmic delivery of the encapsulated cargos by reducing endosomal escape. While this results in a loss of gene expression of encapsulated plasmid DNA, PEG-modification is useful in...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2012/04/01, Vol.35(4), pp.445-448
Hauptverfasser:	Kusumoto, Kenji, Akita, Hidetaka, El-Sayed, Ayman, Harashima, Hideyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line DNA - administration & dosage endosomal escape gene delivery INF7 Lipids - chemistry liposome Liposomes Mice Peptides - chemistry polyethylene glycol modified lipid Polyethylene Glycols - chemistry Transfection - methods
Online-Zugang:	Volltext
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