High frequency of aspirin resistance in patients with nephrotic syndrome
Aspirin has a beneficial role in prevention of cardiovascular and thromboembolic events. Patients may experience thromboembolic events despite aspirin treatment, a phenomenon called aspirin resistance. We evaluated the frequency of aspirin resistance and its correlation with clinical and biochemical...
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| Veröffentlicht in: | Nephrology, dialysis, transplantation dialysis, transplantation, 2012-04, Vol.27 (4), p.1460-1466 |
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| creator | AKOGLU, Hadim AGBAHT, Kemal PISKINPASA, Serhan FALAY, Mesude Y DEDE, Fatih OZET, Gulsum RIZA ODABAS, Ali |
| description | Aspirin has a beneficial role in prevention of cardiovascular and thromboembolic events. Patients may experience thromboembolic events despite aspirin treatment, a phenomenon called aspirin resistance. We evaluated the frequency of aspirin resistance and its correlation with clinical and biochemical parameters among patients with nephrotic syndrome (NS).
A total of 83 patients (50 males, 33 females, age range 18-79 years) with NS using aspirin 100 mg/day were included in the study. Demographic information and aetiology of NS based on the histology of a renal biopsy were recorded for each patient. Blood samples were drawn to investigate the association of aspirin resistance with inflammation and thrombotic risk factors. Aspirin resistance was defined as a normal collagen/epinephrine closure time |
| doi_str_mv | 10.1093/ndt/gfr476 |
| format | Article |
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A total of 83 patients (50 males, 33 females, age range 18-79 years) with NS using aspirin 100 mg/day were included in the study. Demographic information and aetiology of NS based on the histology of a renal biopsy were recorded for each patient. Blood samples were drawn to investigate the association of aspirin resistance with inflammation and thrombotic risk factors. Aspirin resistance was defined as a normal collagen/epinephrine closure time<159 s using a platelet function analyzer (PFA-100).
Aspirin resistance was determined in 51 patients (61.4%). The number of patients exposed to azathioprine therapy was significantly higher in the aspirin-sensitive group (P=0.043), whereas patients exposed to cyclosporine therapy were significantly higher in the aspirin-resistant group (P=0.017). More patients in the aspirin-resistant group were on angiotensin-converting enzyme inhibitor therapy compared with the aspirin-sensitive group (P=0.024). The aspirin-resistant group showed significantly higher serum low-density lipoprotein cholesterol (LDL-C) (151±47 versus 104±21 mg/dL; P<0.001), triglyceride levels (192±116 versus 134±82 mg/dL; P=0.015) and glomerular filtration rates (91.8±43.0 versus 74.0±35.6 mL/min/1.73 m2; P=0.044) compared with the aspirin-sensitive group. In multivariate analysis, LDL-C was the only parameter associated independently with aspirin resistance [odds ratio (OR) 1.04, 95% confidence interval (CI) 1.02-1.06; P=0.004].
A significant number of patients with NS are resistant to aspirin therapy. Serum LDL-C level is closely associated with aspirin resistance in NS.</description><identifier>ISSN: 0931-0509</identifier><identifier>EISSN: 1460-2385</identifier><identifier>DOI: 10.1093/ndt/gfr476</identifier><identifier>PMID: 21865214</identifier><identifier>CODEN: NDTREA</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adolescent ; Adult ; Aged ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Aspirin - adverse effects ; Biological and medical sciences ; Biomarkers - blood ; Emergency and intensive care: renal failure. Dialysis management ; Female ; Follow-Up Studies ; Glomerulonephritis ; Humans ; Inflammation - diagnosis ; Inflammation - etiology ; Intensive care medicine ; Male ; Medical sciences ; Middle Aged ; Nephrology. Urinary tract diseases ; Nephropathies. Renovascular diseases. Renal failure ; Nephrotic Syndrome - complications ; Nephrotic Syndrome - drug therapy ; Platelet Aggregation Inhibitors - adverse effects ; Platelet Function Tests ; Prognosis ; Prospective Studies ; Risk Factors ; Thrombosis - diagnosis ; Thrombosis - etiology ; Young Adult</subject><ispartof>Nephrology, dialysis, transplantation, 2012-04, Vol.27 (4), p.1460-1466</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c352t-9f45942a8f919515f485ff6482824173a60e419c6ed6c838b4adfaf0957989143</citedby><cites>FETCH-LOGICAL-c352t-9f45942a8f919515f485ff6482824173a60e419c6ed6c838b4adfaf0957989143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25703147$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21865214$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>AKOGLU, Hadim</creatorcontrib><creatorcontrib>AGBAHT, Kemal</creatorcontrib><creatorcontrib>PISKINPASA, Serhan</creatorcontrib><creatorcontrib>FALAY, Mesude Y</creatorcontrib><creatorcontrib>DEDE, Fatih</creatorcontrib><creatorcontrib>OZET, Gulsum</creatorcontrib><creatorcontrib>RIZA ODABAS, Ali</creatorcontrib><title>High frequency of aspirin resistance in patients with nephrotic syndrome</title><title>Nephrology, dialysis, transplantation</title><addtitle>Nephrol Dial Transplant</addtitle><description>Aspirin has a beneficial role in prevention of cardiovascular and thromboembolic events. Patients may experience thromboembolic events despite aspirin treatment, a phenomenon called aspirin resistance. We evaluated the frequency of aspirin resistance and its correlation with clinical and biochemical parameters among patients with nephrotic syndrome (NS).
A total of 83 patients (50 males, 33 females, age range 18-79 years) with NS using aspirin 100 mg/day were included in the study. Demographic information and aetiology of NS based on the histology of a renal biopsy were recorded for each patient. Blood samples were drawn to investigate the association of aspirin resistance with inflammation and thrombotic risk factors. Aspirin resistance was defined as a normal collagen/epinephrine closure time<159 s using a platelet function analyzer (PFA-100).
Aspirin resistance was determined in 51 patients (61.4%). The number of patients exposed to azathioprine therapy was significantly higher in the aspirin-sensitive group (P=0.043), whereas patients exposed to cyclosporine therapy were significantly higher in the aspirin-resistant group (P=0.017). More patients in the aspirin-resistant group were on angiotensin-converting enzyme inhibitor therapy compared with the aspirin-sensitive group (P=0.024). The aspirin-resistant group showed significantly higher serum low-density lipoprotein cholesterol (LDL-C) (151±47 versus 104±21 mg/dL; P<0.001), triglyceride levels (192±116 versus 134±82 mg/dL; P=0.015) and glomerular filtration rates (91.8±43.0 versus 74.0±35.6 mL/min/1.73 m2; P=0.044) compared with the aspirin-sensitive group. In multivariate analysis, LDL-C was the only parameter associated independently with aspirin resistance [odds ratio (OR) 1.04, 95% confidence interval (CI) 1.02-1.06; P=0.004].
A significant number of patients with NS are resistant to aspirin therapy. Serum LDL-C level is closely associated with aspirin resistance in NS.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Aspirin - adverse effects</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Emergency and intensive care: renal failure. Dialysis management</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Glomerulonephritis</subject><subject>Humans</subject><subject>Inflammation - diagnosis</subject><subject>Inflammation - etiology</subject><subject>Intensive care medicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Nephropathies. Renovascular diseases. Renal failure</subject><subject>Nephrotic Syndrome - complications</subject><subject>Nephrotic Syndrome - drug therapy</subject><subject>Platelet Aggregation Inhibitors - adverse effects</subject><subject>Platelet Function Tests</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Thrombosis - diagnosis</subject><subject>Thrombosis - etiology</subject><subject>Young Adult</subject><issn>0931-0509</issn><issn>1460-2385</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1LAzEQQIMoWqsXf4DkIoKwNt-bHKWoFQpe9Lyk2aSN7GbXJEX674206mkY5vEYHgBXGN1jpOgstHm2dpHV4ghMMBOoIlTyYzApR1whjtQZOE_pAyGkSF2fgjOCpeAEswlYLPx6A120n1sbzA4ODuo0-ugDjDb5lHUwFpZt1NnbkBP88nkDgx03ccjewLQLbRx6ewFOnO6SvTzMKXh_enybL6rl6_PL_GFZGcpJrpRjXDGipVNYccwdk9w5wSSRhOGaaoEsw8oI2wojqVwx3TrtkOK1kgozOgW3e-8Yh_Jzyk3vk7Fdp4MdtqlRghaX4KiQd3vSxCGlaF0zRt_ruGswan7CNSVcsw9X4OuDdrvqbfuH_pYqwM0B0MnozsUSxqd_jteIYlbTbyHKdnc</recordid><startdate>20120401</startdate><enddate>20120401</enddate><creator>AKOGLU, Hadim</creator><creator>AGBAHT, Kemal</creator><creator>PISKINPASA, Serhan</creator><creator>FALAY, Mesude Y</creator><creator>DEDE, Fatih</creator><creator>OZET, Gulsum</creator><creator>RIZA ODABAS, Ali</creator><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120401</creationdate><title>High frequency of aspirin resistance in patients with nephrotic syndrome</title><author>AKOGLU, Hadim ; AGBAHT, Kemal ; PISKINPASA, Serhan ; FALAY, Mesude Y ; DEDE, Fatih ; OZET, Gulsum ; RIZA ODABAS, Ali</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-9f45942a8f919515f485ff6482824173a60e419c6ed6c838b4adfaf0957989143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Aspirin - adverse effects</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Emergency and intensive care: renal failure. Dialysis management</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Glomerulonephritis</topic><topic>Humans</topic><topic>Inflammation - diagnosis</topic><topic>Inflammation - etiology</topic><topic>Intensive care medicine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Nephropathies. Renovascular diseases. Renal failure</topic><topic>Nephrotic Syndrome - complications</topic><topic>Nephrotic Syndrome - drug therapy</topic><topic>Platelet Aggregation Inhibitors - adverse effects</topic><topic>Platelet Function Tests</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Thrombosis - diagnosis</topic><topic>Thrombosis - etiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>AKOGLU, Hadim</creatorcontrib><creatorcontrib>AGBAHT, Kemal</creatorcontrib><creatorcontrib>PISKINPASA, Serhan</creatorcontrib><creatorcontrib>FALAY, Mesude Y</creatorcontrib><creatorcontrib>DEDE, Fatih</creatorcontrib><creatorcontrib>OZET, Gulsum</creatorcontrib><creatorcontrib>RIZA ODABAS, Ali</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nephrology, dialysis, transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>AKOGLU, Hadim</au><au>AGBAHT, Kemal</au><au>PISKINPASA, Serhan</au><au>FALAY, Mesude Y</au><au>DEDE, Fatih</au><au>OZET, Gulsum</au><au>RIZA ODABAS, Ali</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High frequency of aspirin resistance in patients with nephrotic syndrome</atitle><jtitle>Nephrology, dialysis, transplantation</jtitle><addtitle>Nephrol Dial Transplant</addtitle><date>2012-04-01</date><risdate>2012</risdate><volume>27</volume><issue>4</issue><spage>1460</spage><epage>1466</epage><pages>1460-1466</pages><issn>0931-0509</issn><eissn>1460-2385</eissn><coden>NDTREA</coden><abstract>Aspirin has a beneficial role in prevention of cardiovascular and thromboembolic events. Patients may experience thromboembolic events despite aspirin treatment, a phenomenon called aspirin resistance. We evaluated the frequency of aspirin resistance and its correlation with clinical and biochemical parameters among patients with nephrotic syndrome (NS).
A total of 83 patients (50 males, 33 females, age range 18-79 years) with NS using aspirin 100 mg/day were included in the study. Demographic information and aetiology of NS based on the histology of a renal biopsy were recorded for each patient. Blood samples were drawn to investigate the association of aspirin resistance with inflammation and thrombotic risk factors. Aspirin resistance was defined as a normal collagen/epinephrine closure time<159 s using a platelet function analyzer (PFA-100).
Aspirin resistance was determined in 51 patients (61.4%). The number of patients exposed to azathioprine therapy was significantly higher in the aspirin-sensitive group (P=0.043), whereas patients exposed to cyclosporine therapy were significantly higher in the aspirin-resistant group (P=0.017). More patients in the aspirin-resistant group were on angiotensin-converting enzyme inhibitor therapy compared with the aspirin-sensitive group (P=0.024). The aspirin-resistant group showed significantly higher serum low-density lipoprotein cholesterol (LDL-C) (151±47 versus 104±21 mg/dL; P<0.001), triglyceride levels (192±116 versus 134±82 mg/dL; P=0.015) and glomerular filtration rates (91.8±43.0 versus 74.0±35.6 mL/min/1.73 m2; P=0.044) compared with the aspirin-sensitive group. In multivariate analysis, LDL-C was the only parameter associated independently with aspirin resistance [odds ratio (OR) 1.04, 95% confidence interval (CI) 1.02-1.06; P=0.004].
A significant number of patients with NS are resistant to aspirin therapy. Serum LDL-C level is closely associated with aspirin resistance in NS.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>21865214</pmid><doi>10.1093/ndt/gfr476</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Nephrology, dialysis, transplantation, 2012-04, Vol.27 (4), p.1460-1466 |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Aspirin - adverse effects Biological and medical sciences Biomarkers - blood Emergency and intensive care: renal failure. Dialysis management Female Follow-Up Studies Glomerulonephritis Humans Inflammation - diagnosis Inflammation - etiology Intensive care medicine Male Medical sciences Middle Aged Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Nephrotic Syndrome - complications Nephrotic Syndrome - drug therapy Platelet Aggregation Inhibitors - adverse effects Platelet Function Tests Prognosis Prospective Studies Risk Factors Thrombosis - diagnosis Thrombosis - etiology Young Adult |
| title | High frequency of aspirin resistance in patients with nephrotic syndrome |
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