Oral application of bacterial lysate in infancy decreases the risk of atopic dermatitis in children with 1 atopic parent in a randomized, placebo-controlled trial

Background Lower prevalence of atopy was found in children with continuous exposure to livestock and thus to microbial compounds. In animal models exposure to endotoxin (LPS) decreases allergic sensitization and airway inflammation. Objective We sought to evaluate the effect of orally applied bacter...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2012-04, Vol.129 (4), p.1040-1047
Hauptverfasser:	Lau, Susanne, MD, PhD, Gerhold, Kerstin, MD, PhD, Zimmermann, Kurt, PhD, Ockeloen, Charlotte W., MD, Rossberg, Siri, MD, Wagner, Petra, Sulser, Claudia, MD, Bunikowski, Rita, MD, Witt, Imke, MD, Wauer, Juliane, MD, Beschorner, John, MD, Menke, Georg, PhD, Hamelmann, Eckard, MD, PhD, Wahn, Ulrich, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Age Allergic diseases Allergies Allergy and Immunology Animal models Antibiotics Asthma Atopic dermatitis Bacteria Bacteria - immunology bacterial lysate Biological and medical sciences Child, Preschool Children Children & youth Clinical trials Dermatitis, Atopic - epidemiology Dermatitis, Atopic - immunology Dermatitis, Atopic - prevention & control Desensitization, Immunologic Endotoxins Enterococcus faecalis Escherichia coli Families & family life Feeding Female Fundamental and applied biological sciences. Psychology Fundamental immunology Gene expression Gram-positive bacteria Heredity Humans Immunoglobulin E - blood Immunoglobulin E - immunology Immunopathology infancy Infant Infants Lipopolysaccharides Livestock Male Medical sciences Neonates Parents Population Prevalence primary prevention Respiratory tract diseases Risk Risk assessment Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Skin allergic diseases. Stinging insect allergies Studies
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