A Case of Isoniazid-Induced Thrombocytopenia: Recovery with Immunoglobulin Therapy
Treatment for a 51-year-old man with pulmonary tuberculosis was initiated with isoniazid, rifampicin, ethambutol, and pyrazinamide, and discontinued after 3 weeks because of skin rash and itchiness. Isoniazid monotherapy was restarted after 2 weeks. Two days later, the platelet count decreased from...
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| Veröffentlicht in: | Internal Medicine 2012, Vol.51(7), pp.745-748 |
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| container_title | Internal Medicine |
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| creator | Lee, Eun Ju Lee, Seung Hun Kim, You Eun Lee, Seung Jun Cho, Yu Ji Jeong, Yi Yeong Kim, Ho Cheol Lee, Jong Deog Hwang, Young Sil |
| description | Treatment for a 51-year-old man with pulmonary tuberculosis was initiated with isoniazid, rifampicin, ethambutol, and pyrazinamide, and discontinued after 3 weeks because of skin rash and itchiness. Isoniazid monotherapy was restarted after 2 weeks. Two days later, the platelet count decreased from 150 to 4×103/mm3. Despite platelet transfusion and oral corticosteroid treatment, the platelet count did not recover. However, after a 2-day administration of intravenous immunoglobulin, the platelet count recovered to 209×103/mm3. This report describes a case of isoniazid-induced thrombocytopenia that was reversed with intravenous immunoglobulin, thus highlighting the efficacy of this treatment for this rare condition. |
| doi_str_mv | 10.2169/internalmedicine.51.6296 |
| format | Article |
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Isoniazid monotherapy was restarted after 2 weeks. Two days later, the platelet count decreased from 150 to 4×103/mm3. Despite platelet transfusion and oral corticosteroid treatment, the platelet count did not recover. However, after a 2-day administration of intravenous immunoglobulin, the platelet count recovered to 209×103/mm3. This report describes a case of isoniazid-induced thrombocytopenia that was reversed with intravenous immunoglobulin, thus highlighting the efficacy of this treatment for this rare condition.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.51.6296</identifier><identifier>PMID: 22466831</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>Antitubercular Agents - adverse effects ; Corticoids ; ethambutol ; Exanthema ; Humans ; Immunization, Passive ; Immunoglobulins ; Immunoglobulins, Intravenous - therapeutic use ; Intravenous administration ; intravenous immunoglobulin ; Isoniazid ; Isoniazid - adverse effects ; Lung ; Male ; Middle Aged ; Mycobacterium ; Platelet Count ; Platelets ; pulmonary tuberculosis ; pyrazinamide ; Rifampin ; Skin ; Thrombocytopenia ; Thrombocytopenia - blood ; Thrombocytopenia - chemically induced ; Thrombocytopenia - therapy ; Transfusion ; Tuberculosis ; Tuberculosis, Pulmonary - drug therapy</subject><ispartof>Internal Medicine, 2012, Vol.51(7), pp.745-748</ispartof><rights>2012 by The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c556t-dc7109b5616f1e6316f0035caf3d755daec9cfd5f8a45a7723c34d17c0dfb15b3</citedby><cites>FETCH-LOGICAL-c556t-dc7109b5616f1e6316f0035caf3d755daec9cfd5f8a45a7723c34d17c0dfb15b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1881,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22466831$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Eun Ju</creatorcontrib><creatorcontrib>Lee, Seung Hun</creatorcontrib><creatorcontrib>Kim, You Eun</creatorcontrib><creatorcontrib>Lee, Seung Jun</creatorcontrib><creatorcontrib>Cho, Yu Ji</creatorcontrib><creatorcontrib>Jeong, Yi Yeong</creatorcontrib><creatorcontrib>Kim, Ho Cheol</creatorcontrib><creatorcontrib>Lee, Jong Deog</creatorcontrib><creatorcontrib>Hwang, Young Sil</creatorcontrib><title>A Case of Isoniazid-Induced Thrombocytopenia: Recovery with Immunoglobulin Therapy</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>Treatment for a 51-year-old man with pulmonary tuberculosis was initiated with isoniazid, rifampicin, ethambutol, and pyrazinamide, and discontinued after 3 weeks because of skin rash and itchiness. Isoniazid monotherapy was restarted after 2 weeks. Two days later, the platelet count decreased from 150 to 4×103/mm3. Despite platelet transfusion and oral corticosteroid treatment, the platelet count did not recover. However, after a 2-day administration of intravenous immunoglobulin, the platelet count recovered to 209×103/mm3. This report describes a case of isoniazid-induced thrombocytopenia that was reversed with intravenous immunoglobulin, thus highlighting the efficacy of this treatment for this rare condition.</description><subject>Antitubercular Agents - adverse effects</subject><subject>Corticoids</subject><subject>ethambutol</subject><subject>Exanthema</subject><subject>Humans</subject><subject>Immunization, Passive</subject><subject>Immunoglobulins</subject><subject>Immunoglobulins, Intravenous - therapeutic use</subject><subject>Intravenous administration</subject><subject>intravenous immunoglobulin</subject><subject>Isoniazid</subject><subject>Isoniazid - adverse effects</subject><subject>Lung</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mycobacterium</subject><subject>Platelet Count</subject><subject>Platelets</subject><subject>pulmonary tuberculosis</subject><subject>pyrazinamide</subject><subject>Rifampin</subject><subject>Skin</subject><subject>Thrombocytopenia</subject><subject>Thrombocytopenia - blood</subject><subject>Thrombocytopenia - chemically induced</subject><subject>Thrombocytopenia - therapy</subject><subject>Transfusion</subject><subject>Tuberculosis</subject><subject>Tuberculosis, Pulmonary - drug therapy</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMlOwzAQQC0EgrL8AsoNLimxHdsJN1SxVKqEhMo5cuxJa5TYxU5A5etx1dIDQlxmDvNmewglOBsTzMsbY3vwVrYdaKOMhTHDY05KfoBGmOZlKghlh2iUlbhISQwn6DSEtyyjhSjJMTohJOe8oHiEXu6SiQyQuCaZBmeN_DI6nVo9KNDJfOldVzu17t0KYu02eQHlPsCvk0_TL5Np1w3WLVpXD62xEQcvV-tzdNTINsDFLp-h14f7-eQpnT0_Tid3s1QxxvtUK4GzsmYc8wYDpzHFA5mSDdWCMS1BlarRrClkzqSILymaayxUppsas5qeoavt3JV37wOEvupMUNC20oIbQlVyWpCCMhLJ639JHMXwTOBigxZbVHkXgoemWnnTSb-OULVxX_12XzFcbdzH1svdlqGOxX3jj-wIzLbAW-jlAvaA9L1RLfw5WWyDyNkeU0vpK7D0Gw_xoqk</recordid><startdate>20120101</startdate><enddate>20120101</enddate><creator>Lee, Eun Ju</creator><creator>Lee, Seung Hun</creator><creator>Kim, You Eun</creator><creator>Lee, Seung Jun</creator><creator>Cho, Yu Ji</creator><creator>Jeong, Yi Yeong</creator><creator>Kim, Ho Cheol</creator><creator>Lee, Jong Deog</creator><creator>Hwang, Young Sil</creator><general>The Japanese Society of Internal Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20120101</creationdate><title>A Case of Isoniazid-Induced Thrombocytopenia: Recovery with Immunoglobulin Therapy</title><author>Lee, Eun Ju ; Lee, Seung Hun ; Kim, You Eun ; Lee, Seung Jun ; Cho, Yu Ji ; Jeong, Yi Yeong ; Kim, Ho Cheol ; Lee, Jong Deog ; Hwang, Young Sil</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c556t-dc7109b5616f1e6316f0035caf3d755daec9cfd5f8a45a7723c34d17c0dfb15b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Antitubercular Agents - adverse effects</topic><topic>Corticoids</topic><topic>ethambutol</topic><topic>Exanthema</topic><topic>Humans</topic><topic>Immunization, Passive</topic><topic>Immunoglobulins</topic><topic>Immunoglobulins, Intravenous - therapeutic use</topic><topic>Intravenous administration</topic><topic>intravenous immunoglobulin</topic><topic>Isoniazid</topic><topic>Isoniazid - adverse effects</topic><topic>Lung</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mycobacterium</topic><topic>Platelet Count</topic><topic>Platelets</topic><topic>pulmonary tuberculosis</topic><topic>pyrazinamide</topic><topic>Rifampin</topic><topic>Skin</topic><topic>Thrombocytopenia</topic><topic>Thrombocytopenia - blood</topic><topic>Thrombocytopenia - chemically induced</topic><topic>Thrombocytopenia - therapy</topic><topic>Transfusion</topic><topic>Tuberculosis</topic><topic>Tuberculosis, Pulmonary - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Eun Ju</creatorcontrib><creatorcontrib>Lee, Seung Hun</creatorcontrib><creatorcontrib>Kim, You Eun</creatorcontrib><creatorcontrib>Lee, Seung Jun</creatorcontrib><creatorcontrib>Cho, Yu Ji</creatorcontrib><creatorcontrib>Jeong, Yi Yeong</creatorcontrib><creatorcontrib>Kim, Ho Cheol</creatorcontrib><creatorcontrib>Lee, Jong Deog</creatorcontrib><creatorcontrib>Hwang, Young Sil</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Eun Ju</au><au>Lee, Seung Hun</au><au>Kim, You Eun</au><au>Lee, Seung Jun</au><au>Cho, Yu Ji</au><au>Jeong, Yi Yeong</au><au>Kim, Ho Cheol</au><au>Lee, Jong Deog</au><au>Hwang, Young Sil</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Case of Isoniazid-Induced Thrombocytopenia: Recovery with Immunoglobulin Therapy</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2012-01-01</date><risdate>2012</risdate><volume>51</volume><issue>7</issue><spage>745</spage><epage>748</epage><pages>745-748</pages><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>Treatment for a 51-year-old man with pulmonary tuberculosis was initiated with isoniazid, rifampicin, ethambutol, and pyrazinamide, and discontinued after 3 weeks because of skin rash and itchiness. Isoniazid monotherapy was restarted after 2 weeks. Two days later, the platelet count decreased from 150 to 4×103/mm3. Despite platelet transfusion and oral corticosteroid treatment, the platelet count did not recover. However, after a 2-day administration of intravenous immunoglobulin, the platelet count recovered to 209×103/mm3. This report describes a case of isoniazid-induced thrombocytopenia that was reversed with intravenous immunoglobulin, thus highlighting the efficacy of this treatment for this rare condition.</abstract><cop>Japan</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>22466831</pmid><doi>10.2169/internalmedicine.51.6296</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Antitubercular Agents - adverse effects Corticoids ethambutol Exanthema Humans Immunization, Passive Immunoglobulins Immunoglobulins, Intravenous - therapeutic use Intravenous administration intravenous immunoglobulin Isoniazid Isoniazid - adverse effects Lung Male Middle Aged Mycobacterium Platelet Count Platelets pulmonary tuberculosis pyrazinamide Rifampin Skin Thrombocytopenia Thrombocytopenia - blood Thrombocytopenia - chemically induced Thrombocytopenia - therapy Transfusion Tuberculosis Tuberculosis, Pulmonary - drug therapy |
| title | A Case of Isoniazid-Induced Thrombocytopenia: Recovery with Immunoglobulin Therapy |
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