Anti H-2Dd alloreactivity mediated by herpes-simplex-virus specific cytotoxic H-2k T lymphocytes is associated with H-2Dk
Herpes-simplex-virus (HSV) specific, H-2k-restricted, immune cytotoxic T lymphocytes also lyse noninfected H-2d target cells. Genetic mapping studies revealed that HSV-specific Dk-restricted CTL cross-react with allogeneic targets expressing Dd alloantigens. Cold target inhibition experiments indica...
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| Veröffentlicht in: | Immunogenetics (New York) 1980, Vol.10 (4), p.395-404 |
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| container_title | Immunogenetics (New York) |
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| creator | Pfizenmaier, K Jung, H Kurrle, R Röllinghoff, M Wagner, H |
| description | Herpes-simplex-virus (HSV) specific, H-2k-restricted, immune cytotoxic T lymphocytes also lyse noninfected H-2d target cells. Genetic mapping studies revealed that HSV-specific Dk-restricted CTL cross-react with allogeneic targets expressing Dd alloantigens. Cold target inhibition experiments indicate that only a minority of HSV-specific CTL mediate cross-reactive cytolysis. The data give an example of where the phenomenon of H-2-restricted versus nonrestricted responsiveness is not due to distinct subsets of T cells but solely depends on the antigenic determinants recognized. |
| doi_str_mv | 10.1007/BF01561589 |
| format | Article |
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Genetic mapping studies revealed that HSV-specific Dk-restricted CTL cross-react with allogeneic targets expressing Dd alloantigens. Cold target inhibition experiments indicate that only a minority of HSV-specific CTL mediate cross-reactive cytolysis. 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Genetic mapping studies revealed that HSV-specific Dk-restricted CTL cross-react with allogeneic targets expressing Dd alloantigens. Cold target inhibition experiments indicate that only a minority of HSV-specific CTL mediate cross-reactive cytolysis. The data give an example of where the phenomenon of H-2-restricted versus nonrestricted responsiveness is not due to distinct subsets of T cells but solely depends on the antigenic determinants recognized.</description><subject>Animals</subject><subject>Cross Reactions - immunology</subject><subject>Cytotoxicity, Immunologic</subject><subject>Epitopes - immunology</subject><subject>H-2 Antigens - genetics</subject><subject>H-2 Antigens - immunology</subject><subject>Histocompatibility Antigen H-2D</subject><subject>Isoantibodies - immunology</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred CBA</subject><subject>Simplexvirus - immunology</subject><subject>T-Lymphocytes, Cytotoxic - immunology</subject><issn>0093-7711</issn><issn>1432-1211</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMtOwzAQRS0EoqWw4QOQd0hIAY8dJ_ayFEqRKrEp68h1Jqpp0oQ4Lc3fYyiP1R2Nju5oDiGXwG6BsfTufspAJiCVPiJDiAWPgAMckyFjWkRpCjAgZ96_sYBpnpySAeexTLWAIenHm87RWcQfcmrKsm7R2M7tXNfTCnNnOszpsqcrbBv0kXdVU-I-2rl266lv0LrCWWr7ru7qfZhC0ZouaNlXzaoOa_TUeWq8r-2h68N1q-9z63NyUpjS48VPjsjr9HExmUXzl6fnyXgeWRAAkYgVqDxJuBRWcmRFbK3RogAllnmIvADJ81RpZCrRkpk4_KtkYhUqLAQXI3J96G3a-n2Lvssq5y2WpdlgvfWZTkSseRrLQN4cSNvW3rdYZE3rKtP2GbDsy3T2bzrAVz-122Uw9Yf-qhWfU0N30A</recordid><startdate>1980</startdate><enddate>1980</enddate><creator>Pfizenmaier, K</creator><creator>Jung, H</creator><creator>Kurrle, R</creator><creator>Röllinghoff, M</creator><creator>Wagner, H</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1980</creationdate><title>Anti H-2Dd alloreactivity mediated by herpes-simplex-virus specific cytotoxic H-2k T lymphocytes is associated with H-2Dk</title><author>Pfizenmaier, K ; Jung, H ; Kurrle, R ; Röllinghoff, M ; Wagner, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1311-34818d66253c52e0f4cca93f183bd3f1df152d789e086950a4711856c8e8ef323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Animals</topic><topic>Cross Reactions - immunology</topic><topic>Cytotoxicity, Immunologic</topic><topic>Epitopes - immunology</topic><topic>H-2 Antigens - genetics</topic><topic>H-2 Antigens - immunology</topic><topic>Histocompatibility Antigen H-2D</topic><topic>Isoantibodies - immunology</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred CBA</topic><topic>Simplexvirus - immunology</topic><topic>T-Lymphocytes, Cytotoxic - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pfizenmaier, K</creatorcontrib><creatorcontrib>Jung, H</creatorcontrib><creatorcontrib>Kurrle, R</creatorcontrib><creatorcontrib>Röllinghoff, M</creatorcontrib><creatorcontrib>Wagner, H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Immunogenetics (New York)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pfizenmaier, K</au><au>Jung, H</au><au>Kurrle, R</au><au>Röllinghoff, M</au><au>Wagner, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti H-2Dd alloreactivity mediated by herpes-simplex-virus specific cytotoxic H-2k T lymphocytes is associated with H-2Dk</atitle><jtitle>Immunogenetics (New York)</jtitle><addtitle>Immunogenetics</addtitle><date>1980</date><risdate>1980</risdate><volume>10</volume><issue>4</issue><spage>395</spage><epage>404</epage><pages>395-404</pages><issn>0093-7711</issn><eissn>1432-1211</eissn><abstract>Herpes-simplex-virus (HSV) specific, H-2k-restricted, immune cytotoxic T lymphocytes also lyse noninfected H-2d target cells. Genetic mapping studies revealed that HSV-specific Dk-restricted CTL cross-react with allogeneic targets expressing Dd alloantigens. Cold target inhibition experiments indicate that only a minority of HSV-specific CTL mediate cross-reactive cytolysis. The data give an example of where the phenomenon of H-2-restricted versus nonrestricted responsiveness is not due to distinct subsets of T cells but solely depends on the antigenic determinants recognized.</abstract><cop>United States</cop><pmid>22457931</pmid><doi>10.1007/BF01561589</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0093-7711 |
| ispartof | Immunogenetics (New York), 1980, Vol.10 (4), p.395-404 |
| issn | 0093-7711 1432-1211 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Cross Reactions - immunology Cytotoxicity, Immunologic Epitopes - immunology H-2 Antigens - genetics H-2 Antigens - immunology Histocompatibility Antigen H-2D Isoantibodies - immunology Mice Mice, Inbred BALB C Mice, Inbred CBA Simplexvirus - immunology T-Lymphocytes, Cytotoxic - immunology |
| title | Anti H-2Dd alloreactivity mediated by herpes-simplex-virus specific cytotoxic H-2k T lymphocytes is associated with H-2Dk |
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