Aromatic DNA Adducts and Risk of Gastrointestinal Cancers: A Case―Cohort Study within the EPIC―Spain
Colorectal (CRC) and gastric cancer (GC) are associated with meat intake and tobacco smoke, maybe because of aromatic compounds occurring in tobacco smoking and formed during cooking meat. Activated metabolites of these compounds may bind to DNA forming bulky adducts. Forty-eight subjects diagnosed...
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| Veröffentlicht in: | Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2012-04, Vol.21 (4), p.685-692 |
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| creator | AGUDO, Antonio PELUSO, Marco BARRICARTE, Aurelio ARDANAZ, Eva ARNIANO, Pilar DORRONSORO, Miren RAMON QUIROS, J PIRO, Sara BONET, Catalina SALA, Núria GONZALEZ, Carlos A MUNNIA, Armelle LUJAN-BARROSO, Leila SANCHEZ, María-José MOLINA-MONTES, Esther SANCHEZ-CANTALEJO, Emilio NAVARRO, Carmen TORMO, María-José CHIRLAQUE, Maria-Dolores |
| description | Colorectal (CRC) and gastric cancer (GC) are associated with meat intake and tobacco smoke, maybe because of aromatic compounds occurring in tobacco smoking and formed during cooking meat. Activated metabolites of these compounds may bind to DNA forming bulky adducts.
Forty-eight subjects diagnosed of GC and 154 of CRC during a 7-year follow-up period in the European Prospective Investigation into Cancer and Nutrition-Spain cohort were compared with a sample of 296 subjects using a case-cohort approach. Aromatic adducts to DNA from leukocytes collected at recruitment were measured by means of the (32)P-postlabeling technique. The relative risk (RR) and 95% confidence interval (CI), adjusted by relevant confounders were estimated by a modified version of Cox regression.
Using the log(2)-transformed adduct concentration, we observed a RR = 1.57 (CI: 1.25-1.97) for CRC, which means a 57% increased risk associated with doubling the level of adducts, and 47% (RR = 1.47, CI: 1.07-2.00) increase in risk of GC. The association was more marked for colon than for rectal tumors.
The level of aromatic adducts in the DNA is independently associated with an increased risk of gastric and CRCs. This effect could be due to aromatic compounds present in tobacco smoke or formed in meat, but they could be also due to genotoxic compounds from other sources.
Sources of aromatic compounds should be taken into account, in addition to known risk factors, in the research and prevention of tumors of the stomach, colon, and rectum. |
| doi_str_mv | 10.1158/1055-9965.EPI-11-1205 |
| format | Article |
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Forty-eight subjects diagnosed of GC and 154 of CRC during a 7-year follow-up period in the European Prospective Investigation into Cancer and Nutrition-Spain cohort were compared with a sample of 296 subjects using a case-cohort approach. Aromatic adducts to DNA from leukocytes collected at recruitment were measured by means of the (32)P-postlabeling technique. The relative risk (RR) and 95% confidence interval (CI), adjusted by relevant confounders were estimated by a modified version of Cox regression.
Using the log(2)-transformed adduct concentration, we observed a RR = 1.57 (CI: 1.25-1.97) for CRC, which means a 57% increased risk associated with doubling the level of adducts, and 47% (RR = 1.47, CI: 1.07-2.00) increase in risk of GC. The association was more marked for colon than for rectal tumors.
The level of aromatic adducts in the DNA is independently associated with an increased risk of gastric and CRCs. This effect could be due to aromatic compounds present in tobacco smoke or formed in meat, but they could be also due to genotoxic compounds from other sources.
Sources of aromatic compounds should be taken into account, in addition to known risk factors, in the research and prevention of tumors of the stomach, colon, and rectum.</description><identifier>ISSN: 1055-9965</identifier><identifier>EISSN: 1538-7755</identifier><identifier>DOI: 10.1158/1055-9965.EPI-11-1205</identifier><identifier>PMID: 22315368</identifier><identifier>CODEN: CEBPE4</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Adult ; Aromatic compounds ; Aromatics ; Biological and medical sciences ; biomarkers ; Case-Control Studies ; Colon ; Colorectal Neoplasms - epidemiology ; Colorectal Neoplasms - genetics ; Cooking ; DNA Adducts ; Female ; Follow-Up Studies ; Gastric cancer ; Gastroenterology. Liver. Pancreas. Abdomen ; Genotoxicity ; Guanylate cyclase ; Humans ; Hydrocarbons, Aromatic ; Leukocyte migration ; Male ; Meat ; Meat - adverse effects ; Medical sciences ; Metabolites ; Middle Aged ; Prognosis ; Prospective Studies ; Rectum ; Risk ; Risk Factors ; Smoke ; Smoking - adverse effects ; Spain ; Stomach Neoplasms - epidemiology ; Stomach Neoplasms - genetics ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tobacco smoking ; Tumors</subject><ispartof>Cancer epidemiology, biomarkers & prevention, 2012-04, Vol.21 (4), p.685-692</ispartof><rights>2015 INIST-CNRS</rights><rights>2012 AACR</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-8f591ee1b26d2708ce8ad364888dcc8b9878c7e73e69fb92fb15d12f4329bdbe3</citedby><cites>FETCH-LOGICAL-c418t-8f591ee1b26d2708ce8ad364888dcc8b9878c7e73e69fb92fb15d12f4329bdbe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3356,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25777201$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22315368$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>AGUDO, Antonio</creatorcontrib><creatorcontrib>PELUSO, Marco</creatorcontrib><creatorcontrib>BARRICARTE, Aurelio</creatorcontrib><creatorcontrib>ARDANAZ, Eva</creatorcontrib><creatorcontrib>ARNIANO, Pilar</creatorcontrib><creatorcontrib>DORRONSORO, Miren</creatorcontrib><creatorcontrib>RAMON QUIROS, J</creatorcontrib><creatorcontrib>PIRO, Sara</creatorcontrib><creatorcontrib>BONET, Catalina</creatorcontrib><creatorcontrib>SALA, Núria</creatorcontrib><creatorcontrib>GONZALEZ, Carlos A</creatorcontrib><creatorcontrib>MUNNIA, Armelle</creatorcontrib><creatorcontrib>LUJAN-BARROSO, Leila</creatorcontrib><creatorcontrib>SANCHEZ, María-José</creatorcontrib><creatorcontrib>MOLINA-MONTES, Esther</creatorcontrib><creatorcontrib>SANCHEZ-CANTALEJO, Emilio</creatorcontrib><creatorcontrib>NAVARRO, Carmen</creatorcontrib><creatorcontrib>TORMO, María-José</creatorcontrib><creatorcontrib>CHIRLAQUE, Maria-Dolores</creatorcontrib><title>Aromatic DNA Adducts and Risk of Gastrointestinal Cancers: A Case―Cohort Study within the EPIC―Spain</title><title>Cancer epidemiology, biomarkers & prevention</title><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><description>Colorectal (CRC) and gastric cancer (GC) are associated with meat intake and tobacco smoke, maybe because of aromatic compounds occurring in tobacco smoking and formed during cooking meat. Activated metabolites of these compounds may bind to DNA forming bulky adducts.
Forty-eight subjects diagnosed of GC and 154 of CRC during a 7-year follow-up period in the European Prospective Investigation into Cancer and Nutrition-Spain cohort were compared with a sample of 296 subjects using a case-cohort approach. Aromatic adducts to DNA from leukocytes collected at recruitment were measured by means of the (32)P-postlabeling technique. The relative risk (RR) and 95% confidence interval (CI), adjusted by relevant confounders were estimated by a modified version of Cox regression.
Using the log(2)-transformed adduct concentration, we observed a RR = 1.57 (CI: 1.25-1.97) for CRC, which means a 57% increased risk associated with doubling the level of adducts, and 47% (RR = 1.47, CI: 1.07-2.00) increase in risk of GC. The association was more marked for colon than for rectal tumors.
The level of aromatic adducts in the DNA is independently associated with an increased risk of gastric and CRCs. This effect could be due to aromatic compounds present in tobacco smoke or formed in meat, but they could be also due to genotoxic compounds from other sources.
Sources of aromatic compounds should be taken into account, in addition to known risk factors, in the research and prevention of tumors of the stomach, colon, and rectum.</description><subject>Adult</subject><subject>Aromatic compounds</subject><subject>Aromatics</subject><subject>Biological and medical sciences</subject><subject>biomarkers</subject><subject>Case-Control Studies</subject><subject>Colon</subject><subject>Colorectal Neoplasms - epidemiology</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Cooking</subject><subject>DNA Adducts</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gastric cancer</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Genotoxicity</subject><subject>Guanylate cyclase</subject><subject>Humans</subject><subject>Hydrocarbons, Aromatic</subject><subject>Leukocyte migration</subject><subject>Male</subject><subject>Meat</subject><subject>Meat - adverse effects</subject><subject>Medical sciences</subject><subject>Metabolites</subject><subject>Middle Aged</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Rectum</subject><subject>Risk</subject><subject>Risk Factors</subject><subject>Smoke</subject><subject>Smoking - adverse effects</subject><subject>Spain</subject><subject>Stomach Neoplasms - epidemiology</subject><subject>Stomach Neoplasms - genetics</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Tobacco smoking</subject><subject>Tumors</subject><issn>1055-9965</issn><issn>1538-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kblOxDAQhi0E4n4EkBsETcBHHNt0UTglBIijjhzb0RqyyWI7QnS8BC_Ik-AVC3RUM5r55voHgB2MDjFm4ggjxjIpC3Z4enuZYZxhgtgSWMeMioxzxpaT_8OsgY0QnhBCXDK2CtYIoYkrxDqYlH6Yqug0PLkuYWnMqGOAqjfwzoVnOLTwXIXoB9dHG6LrVQcr1WvrwzEskxvs5_tHNUwGH-F9HM0bfHVx4noYJxamzaqUvp8p12-BlVZ1wW4v7CZ4PDt9qC6yq5vzy6q8ynSORcxEyyS2FjekMIQjoa1Qhha5EMJoLRopuNDccmoL2TaStA1mBpM2p0Q2prF0E-x_95354WVMO9dTF7TtOtXbYQy1LGguCSUokQf_khgRJBiSOU0o-0a1H0Lwtq1n3k2Vf0tQPX9HPZe6nktdp6NTqJ6_I9XtLkaMzdSa36of_ROwtwBU0KprfdLWhT-Occ4JwvQL8SiT1g</recordid><startdate>20120401</startdate><enddate>20120401</enddate><creator>AGUDO, Antonio</creator><creator>PELUSO, Marco</creator><creator>BARRICARTE, Aurelio</creator><creator>ARDANAZ, Eva</creator><creator>ARNIANO, Pilar</creator><creator>DORRONSORO, Miren</creator><creator>RAMON QUIROS, J</creator><creator>PIRO, Sara</creator><creator>BONET, Catalina</creator><creator>SALA, Núria</creator><creator>GONZALEZ, Carlos A</creator><creator>MUNNIA, Armelle</creator><creator>LUJAN-BARROSO, Leila</creator><creator>SANCHEZ, María-José</creator><creator>MOLINA-MONTES, Esther</creator><creator>SANCHEZ-CANTALEJO, Emilio</creator><creator>NAVARRO, Carmen</creator><creator>TORMO, María-José</creator><creator>CHIRLAQUE, Maria-Dolores</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7X8</scope></search><sort><creationdate>20120401</creationdate><title>Aromatic DNA Adducts and Risk of Gastrointestinal Cancers: A Case―Cohort Study within the EPIC―Spain</title><author>AGUDO, Antonio ; PELUSO, Marco ; BARRICARTE, Aurelio ; ARDANAZ, Eva ; ARNIANO, Pilar ; DORRONSORO, Miren ; RAMON QUIROS, J ; PIRO, Sara ; BONET, Catalina ; SALA, Núria ; GONZALEZ, Carlos A ; MUNNIA, Armelle ; LUJAN-BARROSO, Leila ; SANCHEZ, María-José ; MOLINA-MONTES, Esther ; SANCHEZ-CANTALEJO, Emilio ; NAVARRO, Carmen ; TORMO, María-José ; CHIRLAQUE, Maria-Dolores</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-8f591ee1b26d2708ce8ad364888dcc8b9878c7e73e69fb92fb15d12f4329bdbe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Aromatic compounds</topic><topic>Aromatics</topic><topic>Biological and medical sciences</topic><topic>biomarkers</topic><topic>Case-Control Studies</topic><topic>Colon</topic><topic>Colorectal Neoplasms - epidemiology</topic><topic>Colorectal Neoplasms - genetics</topic><topic>Cooking</topic><topic>DNA Adducts</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gastric cancer</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Genotoxicity</topic><topic>Guanylate cyclase</topic><topic>Humans</topic><topic>Hydrocarbons, Aromatic</topic><topic>Leukocyte migration</topic><topic>Male</topic><topic>Meat</topic><topic>Meat - adverse effects</topic><topic>Medical sciences</topic><topic>Metabolites</topic><topic>Middle Aged</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Rectum</topic><topic>Risk</topic><topic>Risk Factors</topic><topic>Smoke</topic><topic>Smoking - adverse effects</topic><topic>Spain</topic><topic>Stomach Neoplasms - epidemiology</topic><topic>Stomach Neoplasms - genetics</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Tobacco smoking</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>AGUDO, Antonio</creatorcontrib><creatorcontrib>PELUSO, Marco</creatorcontrib><creatorcontrib>BARRICARTE, Aurelio</creatorcontrib><creatorcontrib>ARDANAZ, Eva</creatorcontrib><creatorcontrib>ARNIANO, Pilar</creatorcontrib><creatorcontrib>DORRONSORO, Miren</creatorcontrib><creatorcontrib>RAMON QUIROS, J</creatorcontrib><creatorcontrib>PIRO, Sara</creatorcontrib><creatorcontrib>BONET, Catalina</creatorcontrib><creatorcontrib>SALA, Núria</creatorcontrib><creatorcontrib>GONZALEZ, Carlos A</creatorcontrib><creatorcontrib>MUNNIA, Armelle</creatorcontrib><creatorcontrib>LUJAN-BARROSO, Leila</creatorcontrib><creatorcontrib>SANCHEZ, María-José</creatorcontrib><creatorcontrib>MOLINA-MONTES, Esther</creatorcontrib><creatorcontrib>SANCHEZ-CANTALEJO, Emilio</creatorcontrib><creatorcontrib>NAVARRO, Carmen</creatorcontrib><creatorcontrib>TORMO, María-José</creatorcontrib><creatorcontrib>CHIRLAQUE, Maria-Dolores</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>AGUDO, Antonio</au><au>PELUSO, Marco</au><au>BARRICARTE, Aurelio</au><au>ARDANAZ, Eva</au><au>ARNIANO, Pilar</au><au>DORRONSORO, Miren</au><au>RAMON QUIROS, J</au><au>PIRO, Sara</au><au>BONET, Catalina</au><au>SALA, Núria</au><au>GONZALEZ, Carlos A</au><au>MUNNIA, Armelle</au><au>LUJAN-BARROSO, Leila</au><au>SANCHEZ, María-José</au><au>MOLINA-MONTES, Esther</au><au>SANCHEZ-CANTALEJO, Emilio</au><au>NAVARRO, Carmen</au><au>TORMO, María-José</au><au>CHIRLAQUE, Maria-Dolores</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aromatic DNA Adducts and Risk of Gastrointestinal Cancers: A Case―Cohort Study within the EPIC―Spain</atitle><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><date>2012-04-01</date><risdate>2012</risdate><volume>21</volume><issue>4</issue><spage>685</spage><epage>692</epage><pages>685-692</pages><issn>1055-9965</issn><eissn>1538-7755</eissn><coden>CEBPE4</coden><abstract>Colorectal (CRC) and gastric cancer (GC) are associated with meat intake and tobacco smoke, maybe because of aromatic compounds occurring in tobacco smoking and formed during cooking meat. Activated metabolites of these compounds may bind to DNA forming bulky adducts.
Forty-eight subjects diagnosed of GC and 154 of CRC during a 7-year follow-up period in the European Prospective Investigation into Cancer and Nutrition-Spain cohort were compared with a sample of 296 subjects using a case-cohort approach. Aromatic adducts to DNA from leukocytes collected at recruitment were measured by means of the (32)P-postlabeling technique. The relative risk (RR) and 95% confidence interval (CI), adjusted by relevant confounders were estimated by a modified version of Cox regression.
Using the log(2)-transformed adduct concentration, we observed a RR = 1.57 (CI: 1.25-1.97) for CRC, which means a 57% increased risk associated with doubling the level of adducts, and 47% (RR = 1.47, CI: 1.07-2.00) increase in risk of GC. The association was more marked for colon than for rectal tumors.
The level of aromatic adducts in the DNA is independently associated with an increased risk of gastric and CRCs. This effect could be due to aromatic compounds present in tobacco smoke or formed in meat, but they could be also due to genotoxic compounds from other sources.
Sources of aromatic compounds should be taken into account, in addition to known risk factors, in the research and prevention of tumors of the stomach, colon, and rectum.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>22315368</pmid><doi>10.1158/1055-9965.EPI-11-1205</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cancer epidemiology, biomarkers & prevention, 2012-04, Vol.21 (4), p.685-692 |
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| source | MEDLINE; American Association for Cancer Research; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Aromatic compounds Aromatics Biological and medical sciences biomarkers Case-Control Studies Colon Colorectal Neoplasms - epidemiology Colorectal Neoplasms - genetics Cooking DNA Adducts Female Follow-Up Studies Gastric cancer Gastroenterology. Liver. Pancreas. Abdomen Genotoxicity Guanylate cyclase Humans Hydrocarbons, Aromatic Leukocyte migration Male Meat Meat - adverse effects Medical sciences Metabolites Middle Aged Prognosis Prospective Studies Rectum Risk Risk Factors Smoke Smoking - adverse effects Spain Stomach Neoplasms - epidemiology Stomach Neoplasms - genetics Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tobacco smoking Tumors |
| title | Aromatic DNA Adducts and Risk of Gastrointestinal Cancers: A Case―Cohort Study within the EPIC―Spain |
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