Chemical Synthesis of Homogeneous Human Glycosyl-interferon-β That Exhibits Potent Antitumor Activity in Vivo

Chemical synthesis of homogeneous human glycoproteins exhibiting bioactivity in vivo has been a challenging task. In an effort to overcome this long-standing problem, we selected interferon-β and examined its synthesis. The 166 residue polypeptide chain of interferon-β was prepared by covalent conde...

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Veröffentlicht in:	Journal of the American Chemical Society 2012-03, Vol.134 (12), p.5428-5431
Hauptverfasser:	Sakamoto, Izumi, Tezuka, Katsunari, Fukae, Kazuhiro, Ishii, Kazuyuki, Taduru, Keisuke, Maeda, Masatoshi, Ouchi, Masaki, Yoshida, Kenta, Nambu, Yuri, Igarashi, Jun, Hayashi, Naohiro, Tsuji, Takashi, Kajihara, Yasuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - therapeutic use Cell Line Cell Proliferation - drug effects Glycosylation Humans Interferon-beta - chemical synthesis Interferon-beta - chemistry Interferon-beta - therapeutic use Mice Models, Molecular Molecular Sequence Data Neoplasms - drug therapy Xenograft Model Antitumor Assays
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