Oral Ulcers and Necrotizing Gingivitis in Relation to HIV-Associated Neutropenia: A Review and an Illustrative Case
An unusual case of necrotizing gingivitis and neutropenic oral ulcers in an HIV-seropositive patient is presented. In spite of a very low CD4(+) T cell count and severe neutropenia, the necrotizing gingivitis responded favorably to standard periodontal treatment, and the oral ulcers healed after adm...
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| Veröffentlicht in: | AIDS research and human retroviruses 2012-04, Vol.28 (4), p.346-351 |
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| container_title | AIDS research and human retroviruses |
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| creator | FELLER, Liviu KHAMMISSA, Razia A. G WOOD, Neil H MEYEROV, Robin PANTANOWITZ, Liron LEMMER, Johan |
| description | An unusual case of necrotizing gingivitis and neutropenic oral ulcers in an HIV-seropositive patient is presented. In spite of a very low CD4(+) T cell count and severe neutropenia, the necrotizing gingivitis responded favorably to standard periodontal treatment, and the oral ulcers healed after administration of granulocyte colony-stimulating factor (G-CSF). Nonspecific oral ulcers in HIV-seropositive subjects with neutropenia should be regarded as neutropenic ulcers. The term nonspecific ulcers should be restricted to those ulcers with nonspecific histopathological features in patients without neutropenia or a nutritional deficiency such as iron, folic acid, and vitamin B. |
| doi_str_mv | 10.1089/aid.2011.0141 |
| format | Article |
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The term nonspecific ulcers should be restricted to those ulcers with nonspecific histopathological features in patients without neutropenia or a nutritional deficiency such as iron, folic acid, and vitamin B.</description><identifier>ISSN: 0889-2229</identifier><identifier>EISSN: 1931-8405</identifier><identifier>DOI: 10.1089/aid.2011.0141</identifier><identifier>PMID: 21728927</identifier><identifier>CODEN: ARHRE7</identifier><language>eng</language><publisher>New Rochelle, NY: Liebert</publisher><subject>AIDS-Related Opportunistic Infections - drug therapy ; AIDS-Related Opportunistic Infections - etiology ; AIDS/HIV ; Anti-Infective Agents - administration & dosage ; Biological and medical sciences ; CD4 antigen ; Dental Plaque - prevention & control ; Dental Scaling ; Folic acid ; Fundamental and applied biological sciences. Psychology ; Gingivitis ; Gingivitis, Necrotizing Ulcerative - drug therapy ; Gingivitis, Necrotizing Ulcerative - etiology ; Gingivitis, Necrotizing Ulcerative - virology ; Granulocyte colony-stimulating factor ; HIV Seropositivity - complications ; HIV Seropositivity - drug therapy ; Human immunodeficiency virus ; Human viral diseases ; Humans ; Infectious diseases ; Iron ; Lymphocytes T ; Male ; Medical sciences ; Microbiology ; Middle Aged ; Miscellaneous ; Mouthwashes - therapeutic use ; Neutropenia ; Neutropenia - complications ; Neutropenia - virology ; Nutrient deficiency ; Retrovirus ; Treatment Outcome ; Ulcers ; Viral diseases ; Virology ; Vitamins</subject><ispartof>AIDS research and human retroviruses, 2012-04, Vol.28 (4), p.346-351</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c355t-8ee50fa52e5e155a5e066f7ee2684f5d302db43bb067826a33b2f9630359c5933</citedby><cites>FETCH-LOGICAL-c355t-8ee50fa52e5e155a5e066f7ee2684f5d302db43bb067826a33b2f9630359c5933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3042,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26160752$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21728927$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>FELLER, Liviu</creatorcontrib><creatorcontrib>KHAMMISSA, Razia A. G</creatorcontrib><creatorcontrib>WOOD, Neil H</creatorcontrib><creatorcontrib>MEYEROV, Robin</creatorcontrib><creatorcontrib>PANTANOWITZ, Liron</creatorcontrib><creatorcontrib>LEMMER, Johan</creatorcontrib><title>Oral Ulcers and Necrotizing Gingivitis in Relation to HIV-Associated Neutropenia: A Review and an Illustrative Case</title><title>AIDS research and human retroviruses</title><addtitle>AIDS Res Hum Retroviruses</addtitle><description>An unusual case of necrotizing gingivitis and neutropenic oral ulcers in an HIV-seropositive patient is presented. In spite of a very low CD4(+) T cell count and severe neutropenia, the necrotizing gingivitis responded favorably to standard periodontal treatment, and the oral ulcers healed after administration of granulocyte colony-stimulating factor (G-CSF). Nonspecific oral ulcers in HIV-seropositive subjects with neutropenia should be regarded as neutropenic ulcers. The term nonspecific ulcers should be restricted to those ulcers with nonspecific histopathological features in patients without neutropenia or a nutritional deficiency such as iron, folic acid, and vitamin B.</description><subject>AIDS-Related Opportunistic Infections - drug therapy</subject><subject>AIDS-Related Opportunistic Infections - etiology</subject><subject>AIDS/HIV</subject><subject>Anti-Infective Agents - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>CD4 antigen</subject><subject>Dental Plaque - prevention & control</subject><subject>Dental Scaling</subject><subject>Folic acid</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gingivitis</subject><subject>Gingivitis, Necrotizing Ulcerative - drug therapy</subject><subject>Gingivitis, Necrotizing Ulcerative - etiology</subject><subject>Gingivitis, Necrotizing Ulcerative - virology</subject><subject>Granulocyte colony-stimulating factor</subject><subject>HIV Seropositivity - complications</subject><subject>HIV Seropositivity - drug therapy</subject><subject>Human immunodeficiency virus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Iron</subject><subject>Lymphocytes T</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Mouthwashes - therapeutic use</subject><subject>Neutropenia</subject><subject>Neutropenia - complications</subject><subject>Neutropenia - virology</subject><subject>Nutrient deficiency</subject><subject>Retrovirus</subject><subject>Treatment Outcome</subject><subject>Ulcers</subject><subject>Viral diseases</subject><subject>Virology</subject><subject>Vitamins</subject><issn>0889-2229</issn><issn>1931-8405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90TGP1DAQBWALgbjloKRFbhA0WcZ27Nh0qxXcrXTiJMTRRpNkgoy8yWI7i-DX4-UW6Ghmmm9eMY-x5wLWAqx7g35YSxBiDaIWD9hKOCUqW4N-yFZgrauklO6CPUnpKwA4KfVjdiFFI62TzYql24iB34WeYuI4DfwD9XHO_qefvvCrMvzRZ5-4n_hHCpj9PPE88-vd52qT0tx7zHQ6WnKcDzR5fMs3RR49ff8dhxPfhbCkHMvtkfgWEz1lj0YMiZ6d9yW7e__u0_a6urm92m03N1WvtM6VJdIwopakSWiNmsCYsSGSxtajHhTIoatV14FprDSoVCdHZxQo7XrtlLpkr-5zD3H-tlDK7d6nnkLAieYltcXWDqC2Rb7-rxTlwVLUxppCq3ta3pRSpLE9RL_H-KOg9tRIWxppT420p0aKf3GOXro9DX_1nwoKeHkGmHoMY8Sp9-mfM8JAo6X6Bf-Wkqk</recordid><startdate>20120401</startdate><enddate>20120401</enddate><creator>FELLER, Liviu</creator><creator>KHAMMISSA, Razia A. 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Psychology</topic><topic>Gingivitis</topic><topic>Gingivitis, Necrotizing Ulcerative - drug therapy</topic><topic>Gingivitis, Necrotizing Ulcerative - etiology</topic><topic>Gingivitis, Necrotizing Ulcerative - virology</topic><topic>Granulocyte colony-stimulating factor</topic><topic>HIV Seropositivity - complications</topic><topic>HIV Seropositivity - drug therapy</topic><topic>Human immunodeficiency virus</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Iron</topic><topic>Lymphocytes T</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Mouthwashes - therapeutic use</topic><topic>Neutropenia</topic><topic>Neutropenia - complications</topic><topic>Neutropenia - virology</topic><topic>Nutrient deficiency</topic><topic>Retrovirus</topic><topic>Treatment Outcome</topic><topic>Ulcers</topic><topic>Viral diseases</topic><topic>Virology</topic><topic>Vitamins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FELLER, Liviu</creatorcontrib><creatorcontrib>KHAMMISSA, Razia A. 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Nonspecific oral ulcers in HIV-seropositive subjects with neutropenia should be regarded as neutropenic ulcers. The term nonspecific ulcers should be restricted to those ulcers with nonspecific histopathological features in patients without neutropenia or a nutritional deficiency such as iron, folic acid, and vitamin B.</abstract><cop>New Rochelle, NY</cop><pub>Liebert</pub><pmid>21728927</pmid><doi>10.1089/aid.2011.0141</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | AIDS research and human retroviruses, 2012-04, Vol.28 (4), p.346-351 |
| issn | 0889-2229 1931-8405 |
| language | eng |
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| source | MEDLINE; Mary Ann Liebert Online; Alma/SFX Local Collection |
| subjects | AIDS-Related Opportunistic Infections - drug therapy AIDS-Related Opportunistic Infections - etiology AIDS/HIV Anti-Infective Agents - administration & dosage Biological and medical sciences CD4 antigen Dental Plaque - prevention & control Dental Scaling Folic acid Fundamental and applied biological sciences. Psychology Gingivitis Gingivitis, Necrotizing Ulcerative - drug therapy Gingivitis, Necrotizing Ulcerative - etiology Gingivitis, Necrotizing Ulcerative - virology Granulocyte colony-stimulating factor HIV Seropositivity - complications HIV Seropositivity - drug therapy Human immunodeficiency virus Human viral diseases Humans Infectious diseases Iron Lymphocytes T Male Medical sciences Microbiology Middle Aged Miscellaneous Mouthwashes - therapeutic use Neutropenia Neutropenia - complications Neutropenia - virology Nutrient deficiency Retrovirus Treatment Outcome Ulcers Viral diseases Virology Vitamins |
| title | Oral Ulcers and Necrotizing Gingivitis in Relation to HIV-Associated Neutropenia: A Review and an Illustrative Case |
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