Effect of olive oil on transdermal penetration of flurbiprofen from topical gel as enhancer
The present study was conducted to formulate and evaluate flurbiprofen transdermal gel. A standard calibration curve was constructed to obtain a regression line equation to be used for finding out the concentration of drug in samples. Olive oil was used as penetration enhancer and was added in diffe...
Gespeichert in:
| Veröffentlicht in: | Pakistan journal of pharmaceutical sciences 2012-04, Vol.25 (2), p.365-369 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 369 |
|---|---|
| container_issue | 2 |
| container_start_page | 365 |
| container_title | Pakistan journal of pharmaceutical sciences |
| container_volume | 25 |
| creator | Hussain, Abid Khan, Gul Majid Jan, Syed Umer Shah, Shefaatullah Shah, Kifayatullah Akhlaq, Muhammad Rahim, Nouman Nawaz, Asif Wahab, Abdul |
| description | The present study was conducted to formulate and evaluate flurbiprofen transdermal gel. A standard calibration curve was constructed to obtain a regression line equation to be used for finding out the concentration of drug in samples. Olive oil was used as penetration enhancer and was added in different concentrations to some selected formulations to see its enhancement effect on in vitro drug release profiles. The prepared gels were evaluated for several physico-chemical parameters to justify their suitability for topical use. The in vitro drug release studies were carried out by using Franz cell diffusion apparatus across both synthetic membrane and excised albino rabbit skin. In order to investigate the drug release mechanism a kinetic approach was made by employing Korsmeyer kinetic model to the in vitro drug release profiles of flurbiprofen. The flurbiprofen topical gels were successfully prepared and could be beneficial for topical use. |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_963489414</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A292992892</galeid><sourcerecordid>A292992892</sourcerecordid><originalsourceid>FETCH-LOGICAL-g277t-44add448cb4e2e3fe87728c3fc362080be2b72de80848e9869ec376d4357ef3</originalsourceid><addsrcrecordid>eNptkEFLAzEQhfeg2Fr9CxLw4Gklm6TZ5FhKtULBgx4ED0s2O6mRbLImu4L_3kjrQZA5DPP4ZnhvTop5hauq5Lh6mRXnKb1jzJmU8qyYEcKWknE6L143xoAeUTAoOPsJKFiHgkdjVD51EHvl0AAe8jzarGfOuCm2dojBgEcmhh6NYbA6g3twSCUE_k15DfGiODXKJbg89kXxdLd5Xm_L3eP9w3q1K_ekrseSMdV1jAndMiBADYi6JkJToyknWOAWSFuTDgQWTIAUXIKmNe8YXdZg6KK4OVzNjj4mSGPT26TBOeUhTKmRnDIhWcUyeX0g98pBY70JOZX-oZsVkURKIiTJ1O0_VK4OequDB2Oz_mfh6mhganvomiHaXsWv5vfJ9Bs-dnbu</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>963489414</pqid></control><display><type>article</type><title>Effect of olive oil on transdermal penetration of flurbiprofen from topical gel as enhancer</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Hussain, Abid ; Khan, Gul Majid ; Jan, Syed Umer ; Shah, Shefaatullah ; Shah, Kifayatullah ; Akhlaq, Muhammad ; Rahim, Nouman ; Nawaz, Asif ; Wahab, Abdul</creator><creatorcontrib>Hussain, Abid ; Khan, Gul Majid ; Jan, Syed Umer ; Shah, Shefaatullah ; Shah, Kifayatullah ; Akhlaq, Muhammad ; Rahim, Nouman ; Nawaz, Asif ; Wahab, Abdul</creatorcontrib><description>The present study was conducted to formulate and evaluate flurbiprofen transdermal gel. A standard calibration curve was constructed to obtain a regression line equation to be used for finding out the concentration of drug in samples. Olive oil was used as penetration enhancer and was added in different concentrations to some selected formulations to see its enhancement effect on in vitro drug release profiles. The prepared gels were evaluated for several physico-chemical parameters to justify their suitability for topical use. The in vitro drug release studies were carried out by using Franz cell diffusion apparatus across both synthetic membrane and excised albino rabbit skin. In order to investigate the drug release mechanism a kinetic approach was made by employing Korsmeyer kinetic model to the in vitro drug release profiles of flurbiprofen. The flurbiprofen topical gels were successfully prepared and could be beneficial for topical use.</description><identifier>ISSN: 1011-601X</identifier><identifier>PMID: 22459463</identifier><language>eng</language><publisher>Pakistan: Pakistan Journal of Pharmaceutical Sciences</publisher><subject>Animals ; Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics ; Dosage and administration ; Flurbiprofen ; Flurbiprofen - administration & dosage ; Flurbiprofen - chemistry ; Flurbiprofen - pharmacokinetics ; Gels ; Olive Oil ; Plant Oils - pharmacology ; Rabbits ; Skin Absorption - drug effects ; Solubility ; Transdermal medication</subject><ispartof>Pakistan journal of pharmaceutical sciences, 2012-04, Vol.25 (2), p.365-369</ispartof><rights>COPYRIGHT 2012 Pakistan Journal of Pharmaceutical Sciences</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22459463$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hussain, Abid</creatorcontrib><creatorcontrib>Khan, Gul Majid</creatorcontrib><creatorcontrib>Jan, Syed Umer</creatorcontrib><creatorcontrib>Shah, Shefaatullah</creatorcontrib><creatorcontrib>Shah, Kifayatullah</creatorcontrib><creatorcontrib>Akhlaq, Muhammad</creatorcontrib><creatorcontrib>Rahim, Nouman</creatorcontrib><creatorcontrib>Nawaz, Asif</creatorcontrib><creatorcontrib>Wahab, Abdul</creatorcontrib><title>Effect of olive oil on transdermal penetration of flurbiprofen from topical gel as enhancer</title><title>Pakistan journal of pharmaceutical sciences</title><addtitle>Pak J Pharm Sci</addtitle><description>The present study was conducted to formulate and evaluate flurbiprofen transdermal gel. A standard calibration curve was constructed to obtain a regression line equation to be used for finding out the concentration of drug in samples. Olive oil was used as penetration enhancer and was added in different concentrations to some selected formulations to see its enhancement effect on in vitro drug release profiles. The prepared gels were evaluated for several physico-chemical parameters to justify their suitability for topical use. The in vitro drug release studies were carried out by using Franz cell diffusion apparatus across both synthetic membrane and excised albino rabbit skin. In order to investigate the drug release mechanism a kinetic approach was made by employing Korsmeyer kinetic model to the in vitro drug release profiles of flurbiprofen. The flurbiprofen topical gels were successfully prepared and could be beneficial for topical use.</description><subject>Animals</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics</subject><subject>Dosage and administration</subject><subject>Flurbiprofen</subject><subject>Flurbiprofen - administration & dosage</subject><subject>Flurbiprofen - chemistry</subject><subject>Flurbiprofen - pharmacokinetics</subject><subject>Gels</subject><subject>Olive Oil</subject><subject>Plant Oils - pharmacology</subject><subject>Rabbits</subject><subject>Skin Absorption - drug effects</subject><subject>Solubility</subject><subject>Transdermal medication</subject><issn>1011-601X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkEFLAzEQhfeg2Fr9CxLw4Gklm6TZ5FhKtULBgx4ED0s2O6mRbLImu4L_3kjrQZA5DPP4ZnhvTop5hauq5Lh6mRXnKb1jzJmU8qyYEcKWknE6L143xoAeUTAoOPsJKFiHgkdjVD51EHvl0AAe8jzarGfOuCm2dojBgEcmhh6NYbA6g3twSCUE_k15DfGiODXKJbg89kXxdLd5Xm_L3eP9w3q1K_ekrseSMdV1jAndMiBADYi6JkJToyknWOAWSFuTDgQWTIAUXIKmNe8YXdZg6KK4OVzNjj4mSGPT26TBOeUhTKmRnDIhWcUyeX0g98pBY70JOZX-oZsVkURKIiTJ1O0_VK4OequDB2Oz_mfh6mhganvomiHaXsWv5vfJ9Bs-dnbu</recordid><startdate>201204</startdate><enddate>201204</enddate><creator>Hussain, Abid</creator><creator>Khan, Gul Majid</creator><creator>Jan, Syed Umer</creator><creator>Shah, Shefaatullah</creator><creator>Shah, Kifayatullah</creator><creator>Akhlaq, Muhammad</creator><creator>Rahim, Nouman</creator><creator>Nawaz, Asif</creator><creator>Wahab, Abdul</creator><general>Pakistan Journal of Pharmaceutical Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201204</creationdate><title>Effect of olive oil on transdermal penetration of flurbiprofen from topical gel as enhancer</title><author>Hussain, Abid ; Khan, Gul Majid ; Jan, Syed Umer ; Shah, Shefaatullah ; Shah, Kifayatullah ; Akhlaq, Muhammad ; Rahim, Nouman ; Nawaz, Asif ; Wahab, Abdul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g277t-44add448cb4e2e3fe87728c3fc362080be2b72de80848e9869ec376d4357ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics</topic><topic>Dosage and administration</topic><topic>Flurbiprofen</topic><topic>Flurbiprofen - administration & dosage</topic><topic>Flurbiprofen - chemistry</topic><topic>Flurbiprofen - pharmacokinetics</topic><topic>Gels</topic><topic>Olive Oil</topic><topic>Plant Oils - pharmacology</topic><topic>Rabbits</topic><topic>Skin Absorption - drug effects</topic><topic>Solubility</topic><topic>Transdermal medication</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hussain, Abid</creatorcontrib><creatorcontrib>Khan, Gul Majid</creatorcontrib><creatorcontrib>Jan, Syed Umer</creatorcontrib><creatorcontrib>Shah, Shefaatullah</creatorcontrib><creatorcontrib>Shah, Kifayatullah</creatorcontrib><creatorcontrib>Akhlaq, Muhammad</creatorcontrib><creatorcontrib>Rahim, Nouman</creatorcontrib><creatorcontrib>Nawaz, Asif</creatorcontrib><creatorcontrib>Wahab, Abdul</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Pakistan journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hussain, Abid</au><au>Khan, Gul Majid</au><au>Jan, Syed Umer</au><au>Shah, Shefaatullah</au><au>Shah, Kifayatullah</au><au>Akhlaq, Muhammad</au><au>Rahim, Nouman</au><au>Nawaz, Asif</au><au>Wahab, Abdul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of olive oil on transdermal penetration of flurbiprofen from topical gel as enhancer</atitle><jtitle>Pakistan journal of pharmaceutical sciences</jtitle><addtitle>Pak J Pharm Sci</addtitle><date>2012-04</date><risdate>2012</risdate><volume>25</volume><issue>2</issue><spage>365</spage><epage>369</epage><pages>365-369</pages><issn>1011-601X</issn><abstract>The present study was conducted to formulate and evaluate flurbiprofen transdermal gel. A standard calibration curve was constructed to obtain a regression line equation to be used for finding out the concentration of drug in samples. Olive oil was used as penetration enhancer and was added in different concentrations to some selected formulations to see its enhancement effect on in vitro drug release profiles. The prepared gels were evaluated for several physico-chemical parameters to justify their suitability for topical use. The in vitro drug release studies were carried out by using Franz cell diffusion apparatus across both synthetic membrane and excised albino rabbit skin. In order to investigate the drug release mechanism a kinetic approach was made by employing Korsmeyer kinetic model to the in vitro drug release profiles of flurbiprofen. The flurbiprofen topical gels were successfully prepared and could be beneficial for topical use.</abstract><cop>Pakistan</cop><pub>Pakistan Journal of Pharmaceutical Sciences</pub><pmid>22459463</pmid><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1011-601X |
| ispartof | Pakistan journal of pharmaceutical sciences, 2012-04, Vol.25 (2), p.365-369 |
| issn | 1011-601X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_963489414 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics Dosage and administration Flurbiprofen Flurbiprofen - administration & dosage Flurbiprofen - chemistry Flurbiprofen - pharmacokinetics Gels Olive Oil Plant Oils - pharmacology Rabbits Skin Absorption - drug effects Solubility Transdermal medication |
| title | Effect of olive oil on transdermal penetration of flurbiprofen from topical gel as enhancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T17%3A25%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20olive%20oil%20on%20transdermal%20penetration%20of%20flurbiprofen%20from%20topical%20gel%20as%20enhancer&rft.jtitle=Pakistan%20journal%20of%20pharmaceutical%20sciences&rft.au=Hussain,%20Abid&rft.date=2012-04&rft.volume=25&rft.issue=2&rft.spage=365&rft.epage=369&rft.pages=365-369&rft.issn=1011-601X&rft_id=info:doi/&rft_dat=%3Cgale_proqu%3EA292992892%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=963489414&rft_id=info:pmid/22459463&rft_galeid=A292992892&rfr_iscdi=true |