Warfarin Genotyping in a Single PCR Reaction for Microchip Electrophoresis

Warfarin is the most commonly prescribed oral anticoagulant medication but also is the second leading cause of emergency room visits for adverse drug reactions. Genetic testing for warfarin sensitivity may reduce hospitalization rates, but prospective genotyping is impeded in part by the turnaround...

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Veröffentlicht in:	Clinical chemistry (Baltimore, Md.) Md.), 2012-04, Vol.58 (4), p.725-731
Hauptverfasser:	POE, Brian L, HAVERSTICK, Doris M, LANDERS, James P
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Anticoagulants Anticoagulants - administration & dosage Aryl Hydrocarbon Hydroxylases - genetics Base Sequence Biological and medical sciences Conflicts of interest Costs Cytochrome P-450 CYP2C9 Cytochrome P450 Design DNA Primers Drugs Electrophoresis Electrophoresis, Microchip Emergency medical care Epoxides Fundamental and applied biological sciences. Psychology Genetic screening genomics Genotype Genotype & phenotype Genotypes Genotyping Haplotypes Humans Investigative techniques, diagnostic techniques (general aspects) Medical sciences Methods Microbiology microchips Microfluidic Analytical Techniques Microfluidics Mixed Function Oxygenases - genetics Molecular biophysics Molecular Sequence Data Mutation Oligonucleotide Array Sequence Analysis Polymerase chain reaction Polymerase Chain Reaction - methods Primers reductase Side effects Single-nucleotide polymorphism Vitamin K Vitamin K Epoxide Reductases Warfarin Warfarin - administration & dosage
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