Is joint hypermobility associated with vesico‐ureteral reflux? An assessment of 50 patients
Study Type – Aetiology (individual cohort) Level of Evidence 2b What's known on the subject? and What does the study add? Recent studies have already shown associations between generalized joint hypermobility (GJH) and voiding and defecation dysfunction and/or slow transit constipation. Changes...
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| Veröffentlicht in: | BJU international 2012-04, Vol.109 (8), p.1243-1248 |
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| creator | van Eerde, Albertien M. Verhoeven, Virginie J.M. de Jong, Tom P.V.M. van de Putte, Elise M. Giltay, Jacques C. Engelbert, Raoul H.H. |
| description | Study Type – Aetiology (individual cohort)
Level of Evidence 2b
What's known on the subject? and What does the study add?
Recent studies have already shown associations between generalized joint hypermobility (GJH) and voiding and defecation dysfunction and/or slow transit constipation. Changes in extracellular matrix composition in vesico‐ureteric junction of vesico‐ureteral reflux (VUR) patients were also observed previously.
This study is the first to assess joint mobility as a parameter for connective tissue composition in vesico‐ureteral reflux. We convincingly demonstrate that VUR patients have significantly more hypermobile joints compared to controls and this provides a new angle to the intriguing subjects of development of VUR and susceptibility to VUR.
OBJECTIVE
•
To assess whether there is an increased prevalence of joint hypermobility in patients with vesico‐ureteric reflux (VUR).
MATERIALS AND METHODS
•
We studied 50 patients with primary VUR and matched controls drawn from a reference population.
•
Joint mobility was assessed using the Bulbena hypermobility score.
RESULTS
•
We identified significantly more patients with VUR with generalized joint hypermobility than controls (24% vs 6.7%, P= 0.007).
CONCLUSION
•
Our findings confirm our clinical observation of an increased rate of joint hypermobility in patients with VUR. We speculate that an altered composition of the connective tissue may contribute to the severity of the (pre‐existing) VUR phenotype. |
| doi_str_mv | 10.1111/j.1464-410X.2011.10469.x |
| format | Article |
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Level of Evidence 2b
What's known on the subject? and What does the study add?
Recent studies have already shown associations between generalized joint hypermobility (GJH) and voiding and defecation dysfunction and/or slow transit constipation. Changes in extracellular matrix composition in vesico‐ureteric junction of vesico‐ureteral reflux (VUR) patients were also observed previously.
This study is the first to assess joint mobility as a parameter for connective tissue composition in vesico‐ureteral reflux. We convincingly demonstrate that VUR patients have significantly more hypermobile joints compared to controls and this provides a new angle to the intriguing subjects of development of VUR and susceptibility to VUR.
OBJECTIVE
•
To assess whether there is an increased prevalence of joint hypermobility in patients with vesico‐ureteric reflux (VUR).
MATERIALS AND METHODS
•
We studied 50 patients with primary VUR and matched controls drawn from a reference population.
•
Joint mobility was assessed using the Bulbena hypermobility score.
RESULTS
•
We identified significantly more patients with VUR with generalized joint hypermobility than controls (24% vs 6.7%, P= 0.007).
CONCLUSION
•
Our findings confirm our clinical observation of an increased rate of joint hypermobility in patients with VUR. We speculate that an altered composition of the connective tissue may contribute to the severity of the (pre‐existing) VUR phenotype.</description><identifier>ISSN: 1464-4096</identifier><identifier>EISSN: 1464-410X</identifier><identifier>DOI: 10.1111/j.1464-410X.2011.10469.x</identifier><identifier>PMID: 21883843</identifier><identifier>CODEN: BJINFO</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Bacterial diseases ; Bacterial diseases of the urinary system ; Biological and medical sciences ; Child ; connective tissue ; extracellular matrix ; Female ; Human bacterial diseases ; Humans ; Incidence ; Infectious diseases ; joint instability ; Joint Instability - complications ; Joint Instability - epidemiology ; Male ; Medical sciences ; Nephrology. Urinary tract diseases ; Netherlands - epidemiology ; Prevalence ; Risk Assessment ; Risk Factors ; ROC Curve ; Surveys and Questionnaires ; Urinary system involvement in other diseases. Miscellaneous ; urinary tract infections ; Urinary tract. Prostate gland ; Vesico-Ureteral Reflux - epidemiology ; Vesico-Ureteral Reflux - etiology ; vesico‐ureteric reflux</subject><ispartof>BJU international, 2012-04, Vol.109 (8), p.1243-1248</ispartof><rights>2011 THE AUTHORS. BJU INTERNATIONAL © 2011 BJU INTERNATIONAL</rights><rights>2015 INIST-CNRS</rights><rights>2011 THE AUTHORS. BJU INTERNATIONAL © 2011 BJU INTERNATIONAL.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4779-1d02b52fb3e16b55d385555b48bafd1b32fdc0c0fab5c7332d7040ec55abc2273</citedby><cites>FETCH-LOGICAL-c4779-1d02b52fb3e16b55d385555b48bafd1b32fdc0c0fab5c7332d7040ec55abc2273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1464-410X.2011.10469.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1464-410X.2011.10469.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25783529$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21883843$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Eerde, Albertien M.</creatorcontrib><creatorcontrib>Verhoeven, Virginie J.M.</creatorcontrib><creatorcontrib>de Jong, Tom P.V.M.</creatorcontrib><creatorcontrib>van de Putte, Elise M.</creatorcontrib><creatorcontrib>Giltay, Jacques C.</creatorcontrib><creatorcontrib>Engelbert, Raoul H.H.</creatorcontrib><title>Is joint hypermobility associated with vesico‐ureteral reflux? An assessment of 50 patients</title><title>BJU international</title><addtitle>BJU Int</addtitle><description>Study Type – Aetiology (individual cohort)
Level of Evidence 2b
What's known on the subject? and What does the study add?
Recent studies have already shown associations between generalized joint hypermobility (GJH) and voiding and defecation dysfunction and/or slow transit constipation. Changes in extracellular matrix composition in vesico‐ureteric junction of vesico‐ureteral reflux (VUR) patients were also observed previously.
This study is the first to assess joint mobility as a parameter for connective tissue composition in vesico‐ureteral reflux. We convincingly demonstrate that VUR patients have significantly more hypermobile joints compared to controls and this provides a new angle to the intriguing subjects of development of VUR and susceptibility to VUR.
OBJECTIVE
•
To assess whether there is an increased prevalence of joint hypermobility in patients with vesico‐ureteric reflux (VUR).
MATERIALS AND METHODS
•
We studied 50 patients with primary VUR and matched controls drawn from a reference population.
•
Joint mobility was assessed using the Bulbena hypermobility score.
RESULTS
•
We identified significantly more patients with VUR with generalized joint hypermobility than controls (24% vs 6.7%, P= 0.007).
CONCLUSION
•
Our findings confirm our clinical observation of an increased rate of joint hypermobility in patients with VUR. We speculate that an altered composition of the connective tissue may contribute to the severity of the (pre‐existing) VUR phenotype.</description><subject>Adolescent</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the urinary system</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>connective tissue</subject><subject>extracellular matrix</subject><subject>Female</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infectious diseases</subject><subject>joint instability</subject><subject>Joint Instability - complications</subject><subject>Joint Instability - epidemiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Netherlands - epidemiology</subject><subject>Prevalence</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>ROC Curve</subject><subject>Surveys and Questionnaires</subject><subject>Urinary system involvement in other diseases. Miscellaneous</subject><subject>urinary tract infections</subject><subject>Urinary tract. Prostate gland</subject><subject>Vesico-Ureteral Reflux - epidemiology</subject><subject>Vesico-Ureteral Reflux - etiology</subject><subject>vesico‐ureteric reflux</subject><issn>1464-4096</issn><issn>1464-410X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1O3DAQxy3UCijlFZAlVHHa1J_5uLQC1FIqpF6K1AuybMcRjpJ460lg99ZH6DP2SXDYBSROnYtn7N98-D8IYUoymuxjm1GRi4Wg5FfGCKUZJSKvstUO2n9-ePPkkyrfQ-8AWkLSRS530R6jZclLwffRzSXgNvhhxLfrpYt9ML7z4xprgGC9Hl2N7_14i-8ceBv-_fk7RTe6qDscXdNNq8_4dJhhB9C7VCU0WBK81KNPEbxHbxvdgTvcngfo-uuXn-ffFlc_Li7PT68WVhRFtaA1YUayxnBHcyNlzUuZzIjS6KamhrOmtsSSRhtpC85ZXRBBnJVSG8tYwQ_QyabuMobfk4NR9R6s6zo9uDCBqnIuytRJJvL4FdmGKQ5pOEW55DxnnM71yg1lYwBIP1XL6Hsd14oSNW9AtWoWV81Cq3kD6nEDapVSj7YNJtO7-jnxSfIEfNgCGqzumqgH6-GFk0XJJasS92nD3fvOrf97AHX2_frR5Q_2lKMU</recordid><startdate>201204</startdate><enddate>201204</enddate><creator>van Eerde, Albertien M.</creator><creator>Verhoeven, Virginie J.M.</creator><creator>de Jong, Tom P.V.M.</creator><creator>van de Putte, Elise M.</creator><creator>Giltay, Jacques C.</creator><creator>Engelbert, Raoul H.H.</creator><general>Blackwell Publishing Ltd</general><general>Wiley-Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>201204</creationdate><title>Is joint hypermobility associated with vesico‐ureteral reflux? An assessment of 50 patients</title><author>van Eerde, Albertien M. ; Verhoeven, Virginie J.M. ; de Jong, Tom P.V.M. ; van de Putte, Elise M. ; Giltay, Jacques C. ; Engelbert, Raoul H.H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4779-1d02b52fb3e16b55d385555b48bafd1b32fdc0c0fab5c7332d7040ec55abc2273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Bacterial diseases</topic><topic>Bacterial diseases of the urinary system</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>connective tissue</topic><topic>extracellular matrix</topic><topic>Female</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infectious diseases</topic><topic>joint instability</topic><topic>Joint Instability - complications</topic><topic>Joint Instability - epidemiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Netherlands - epidemiology</topic><topic>Prevalence</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>ROC Curve</topic><topic>Surveys and Questionnaires</topic><topic>Urinary system involvement in other diseases. Miscellaneous</topic><topic>urinary tract infections</topic><topic>Urinary tract. Prostate gland</topic><topic>Vesico-Ureteral Reflux - epidemiology</topic><topic>Vesico-Ureteral Reflux - etiology</topic><topic>vesico‐ureteric reflux</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Eerde, Albertien M.</creatorcontrib><creatorcontrib>Verhoeven, Virginie J.M.</creatorcontrib><creatorcontrib>de Jong, Tom P.V.M.</creatorcontrib><creatorcontrib>van de Putte, Elise M.</creatorcontrib><creatorcontrib>Giltay, Jacques C.</creatorcontrib><creatorcontrib>Engelbert, Raoul H.H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>BJU international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Eerde, Albertien M.</au><au>Verhoeven, Virginie J.M.</au><au>de Jong, Tom P.V.M.</au><au>van de Putte, Elise M.</au><au>Giltay, Jacques C.</au><au>Engelbert, Raoul H.H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is joint hypermobility associated with vesico‐ureteral reflux? An assessment of 50 patients</atitle><jtitle>BJU international</jtitle><addtitle>BJU Int</addtitle><date>2012-04</date><risdate>2012</risdate><volume>109</volume><issue>8</issue><spage>1243</spage><epage>1248</epage><pages>1243-1248</pages><issn>1464-4096</issn><eissn>1464-410X</eissn><coden>BJINFO</coden><abstract>Study Type – Aetiology (individual cohort)
Level of Evidence 2b
What's known on the subject? and What does the study add?
Recent studies have already shown associations between generalized joint hypermobility (GJH) and voiding and defecation dysfunction and/or slow transit constipation. Changes in extracellular matrix composition in vesico‐ureteric junction of vesico‐ureteral reflux (VUR) patients were also observed previously.
This study is the first to assess joint mobility as a parameter for connective tissue composition in vesico‐ureteral reflux. We convincingly demonstrate that VUR patients have significantly more hypermobile joints compared to controls and this provides a new angle to the intriguing subjects of development of VUR and susceptibility to VUR.
OBJECTIVE
•
To assess whether there is an increased prevalence of joint hypermobility in patients with vesico‐ureteric reflux (VUR).
MATERIALS AND METHODS
•
We studied 50 patients with primary VUR and matched controls drawn from a reference population.
•
Joint mobility was assessed using the Bulbena hypermobility score.
RESULTS
•
We identified significantly more patients with VUR with generalized joint hypermobility than controls (24% vs 6.7%, P= 0.007).
CONCLUSION
•
Our findings confirm our clinical observation of an increased rate of joint hypermobility in patients with VUR. We speculate that an altered composition of the connective tissue may contribute to the severity of the (pre‐existing) VUR phenotype.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21883843</pmid><doi>10.1111/j.1464-410X.2011.10469.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library |
| subjects | Adolescent Bacterial diseases Bacterial diseases of the urinary system Biological and medical sciences Child connective tissue extracellular matrix Female Human bacterial diseases Humans Incidence Infectious diseases joint instability Joint Instability - complications Joint Instability - epidemiology Male Medical sciences Nephrology. Urinary tract diseases Netherlands - epidemiology Prevalence Risk Assessment Risk Factors ROC Curve Surveys and Questionnaires Urinary system involvement in other diseases. Miscellaneous urinary tract infections Urinary tract. Prostate gland Vesico-Ureteral Reflux - epidemiology Vesico-Ureteral Reflux - etiology vesico‐ureteric reflux |
| title | Is joint hypermobility associated with vesico‐ureteral reflux? An assessment of 50 patients |
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