Thorough QT/QTc Study of Ritonavir-Boosted Saquinavir Following Multiple-Dose Administration of Therapeutic and Supratherapeutic Doses in Healthy Participants

The effect of saquinavir-boosted ritonavir at therapeutic (1000/100 mg twice daily [bid]) and supratherapeutic (1500/100 mg bid) doses was evaluated in a double-blind, placebo- and positive-controlled (moxifloxacin 400 mg) 4-way crossover thorough QT/QTc study. Least squares mean estimated study-spe...

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Veröffentlicht in:	Journal of clinical pharmacology 2012-04, Vol.52 (4), p.520-529
Hauptverfasser:	Zhang, Xiaoping, Jordan, Paul, Cristea, Laura, Salgo, Miklos, Farha, Rana, Kolis, Stanley, Lee, Lois S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aza Compounds - adverse effects Confidence intervals Cross-Over Studies Dose-Response Relationship, Drug Double-Blind Method Drug Therapy, Combination Electrocardiography Female Fluoroquinolones HIV Protease Inhibitors - administration & dosage HIV Protease Inhibitors - adverse effects Humans Least-Squares Analysis Long QT Syndrome - chemically induced Male Middle Aged moxifloxacin Quinolines - adverse effects ritonavir Ritonavir - administration & dosage Ritonavir - adverse effects Saquinavir Saquinavir - administration & dosage Saquinavir - adverse effects thorough QT/QTc study Torsades de Pointes - chemically induced Young Adult
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