Markers of Inflammation and Fat Distribution Following Weight Loss in African‐American and White Women
Changes in markers of inflammation (MOI) and fat distribution with weight loss between African‐American (AA) and white (W) women have yet to be characterized. The purpose of this study was to examine potential ethnic differences in MOI and regional fat distribution with weight loss, and identify the...
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| Veröffentlicht in: | Obesity (Silver Spring, Md.) Md.), 2012-04, Vol.20 (4), p.715-720 |
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| creator | Fisher, Gordon Hyatt, Tanya C. Hunter, Gary R. Oster, Robert A. Desmond, Renee A. Gower, Barbara A. |
| description | Changes in markers of inflammation (MOI) and fat distribution with weight loss between African‐American (AA) and white (W) women have yet to be characterized. The purpose of this study was to examine potential ethnic differences in MOI and regional fat distribution with weight loss, and identify the associations between these markers and changes in regional fat distribution with weight loss among AA and W women. Subjects were 126 healthy, premenopausal women, BMI 27–30 kg/m2. They were placed on a weight‐loss intervention consisting of diet and/or exercise until a BMI |
| doi_str_mv | 10.1038/oby.2011.85 |
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The purpose of this study was to examine potential ethnic differences in MOI and regional fat distribution with weight loss, and identify the associations between these markers and changes in regional fat distribution with weight loss among AA and W women. Subjects were 126 healthy, premenopausal women, BMI 27–30 kg/m2. They were placed on a weight‐loss intervention consisting of diet and/or exercise until a BMI <25 was achieved. Fat distribution was measured with computed tomography, and body composition with dual‐energy X‐ray absorptiometry. Serum concentrations of tumor necrosis factor‐α (TNF‐α), soluble TNF receptor‐I (sTNFR‐I), sTNFR‐II, C‐reactive protein (CRP), and interleukin‐6 (IL‐6) were assessed. All MOI and adiposity measures significantly decreased with weight loss. Significant ethnic differences with weight loss were observed for fat mass, body fat, intra‐abdominal adipose tissue (IAAT), sTNFR‐I, and sTNFR‐II. Mixed‐model analysis indicated that adjusting for change in IAAT explained ethnic differences in change in TNF‐α and the decrease in TNF‐α with weight loss, while total fat mass only explained the decrease in sTNFR‐I and sTNFR‐II with weight loss. In conclusion, all MOI decreased following weight loss among W, whereas only IL‐6 and CRP decreased following weight loss in AA. The most distinct phenotypic difference observed was a greater impact of weight loss on TNF‐α in W compared to AA, which was directly associated with IAAT in W.</description><identifier>ISSN: 1930-7381</identifier><identifier>EISSN: 1930-739X</identifier><identifier>DOI: 10.1038/oby.2011.85</identifier><identifier>PMID: 21527894</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Absorptiometry, Photon ; Adult ; African Americans ; Biomarkers - blood ; Body Composition ; Body Fat Distribution ; Body Mass Index ; C-Reactive Protein - metabolism ; European Continental Ancestry Group ; Female ; Humans ; Inflammation - blood ; Inflammation - ethnology ; Interleukin-6 - blood ; Obesity - blood ; Obesity - ethnology ; Receptors, Tumor Necrosis Factor, Type I - blood ; Receptors, Tumor Necrosis Factor, Type II - blood ; Tumor Necrosis Factor-alpha - blood ; Weight Loss - ethnology</subject><ispartof>Obesity (Silver Spring, Md.), 2012-04, Vol.20 (4), p.715-720</ispartof><rights>2012 North American Association for the Study of Obesity (NAASO)</rights><rights>Copyright Nature Publishing Group Apr 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3947-692a83b823f2626f027235461afdad2e133c149fdfff8ad1574c684640807d483</citedby><cites>FETCH-LOGICAL-c3947-692a83b823f2626f027235461afdad2e133c149fdfff8ad1574c684640807d483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1038%2Foby.2011.85$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1038%2Foby.2011.85$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27903,27904,45553,45554,46387,46811</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21527894$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fisher, Gordon</creatorcontrib><creatorcontrib>Hyatt, Tanya C.</creatorcontrib><creatorcontrib>Hunter, Gary R.</creatorcontrib><creatorcontrib>Oster, Robert A.</creatorcontrib><creatorcontrib>Desmond, Renee A.</creatorcontrib><creatorcontrib>Gower, Barbara A.</creatorcontrib><title>Markers of Inflammation and Fat Distribution Following Weight Loss in African‐American and White Women</title><title>Obesity (Silver Spring, Md.)</title><addtitle>Obesity (Silver Spring)</addtitle><description>Changes in markers of inflammation (MOI) and fat distribution with weight loss between African‐American (AA) and white (W) women have yet to be characterized. The purpose of this study was to examine potential ethnic differences in MOI and regional fat distribution with weight loss, and identify the associations between these markers and changes in regional fat distribution with weight loss among AA and W women. Subjects were 126 healthy, premenopausal women, BMI 27–30 kg/m2. They were placed on a weight‐loss intervention consisting of diet and/or exercise until a BMI <25 was achieved. Fat distribution was measured with computed tomography, and body composition with dual‐energy X‐ray absorptiometry. Serum concentrations of tumor necrosis factor‐α (TNF‐α), soluble TNF receptor‐I (sTNFR‐I), sTNFR‐II, C‐reactive protein (CRP), and interleukin‐6 (IL‐6) were assessed. All MOI and adiposity measures significantly decreased with weight loss. Significant ethnic differences with weight loss were observed for fat mass, body fat, intra‐abdominal adipose tissue (IAAT), sTNFR‐I, and sTNFR‐II. Mixed‐model analysis indicated that adjusting for change in IAAT explained ethnic differences in change in TNF‐α and the decrease in TNF‐α with weight loss, while total fat mass only explained the decrease in sTNFR‐I and sTNFR‐II with weight loss. In conclusion, all MOI decreased following weight loss among W, whereas only IL‐6 and CRP decreased following weight loss in AA. The most distinct phenotypic difference observed was a greater impact of weight loss on TNF‐α in W compared to AA, which was directly associated with IAAT in W.</description><subject>Absorptiometry, Photon</subject><subject>Adult</subject><subject>African Americans</subject><subject>Biomarkers - blood</subject><subject>Body Composition</subject><subject>Body Fat Distribution</subject><subject>Body Mass Index</subject><subject>C-Reactive Protein - metabolism</subject><subject>European Continental Ancestry Group</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammation - blood</subject><subject>Inflammation - ethnology</subject><subject>Interleukin-6 - blood</subject><subject>Obesity - blood</subject><subject>Obesity - ethnology</subject><subject>Receptors, Tumor Necrosis Factor, Type I - blood</subject><subject>Receptors, Tumor Necrosis Factor, Type II - blood</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><subject>Weight Loss - ethnology</subject><issn>1930-7381</issn><issn>1930-739X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kLtOwzAUhi0E4lKY2JElBgbU4lsceyyXAlIRC6gwWW5iU0Nig50IdeMReEaehNACAwPT-XX06dc5HwC7GA0wouIoTOcDgjAeiGwFbGJJUT-n8m71Nwu8AbZSekSIcZThdbBBcEZyIdkmmF3p-GRigsHCS28rXde6ccFD7Us40g08damJbtoulqNQVeHV-Qc4Me5h1sBxSAk6D4c2ukL7j7f3YW0WcVEwmbnGwEmojd8Ga1ZXyex8zx64HZ3dnFz0x9fnlyfDcb-gkuV9LokWdCoItYQTbhHJCc0Yx9qWuiQGU1pgJm1prRW6xFnOCi4YZ0igvGSC9sDBsvc5hpfWpEbVLhWmqrQ3oU1KZhJTJjHryP0_5GNoo--OUxhhyjlHncAeOFxSRex-jcaq5-hqHecdpL78q86_-vKvRNbRe9-d7bQ25S_7I7wD0BJ4dZWZ_9elro_vSSZz-gm9lY-O</recordid><startdate>201204</startdate><enddate>201204</enddate><creator>Fisher, Gordon</creator><creator>Hyatt, Tanya C.</creator><creator>Hunter, Gary R.</creator><creator>Oster, Robert A.</creator><creator>Desmond, Renee A.</creator><creator>Gower, Barbara A.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201204</creationdate><title>Markers of Inflammation and Fat Distribution Following Weight Loss in African‐American and White Women</title><author>Fisher, Gordon ; Hyatt, Tanya C. ; Hunter, Gary R. ; Oster, Robert A. ; Desmond, Renee A. ; Gower, Barbara A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3947-692a83b823f2626f027235461afdad2e133c149fdfff8ad1574c684640807d483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Absorptiometry, Photon</topic><topic>Adult</topic><topic>African Americans</topic><topic>Biomarkers - blood</topic><topic>Body Composition</topic><topic>Body Fat Distribution</topic><topic>Body Mass Index</topic><topic>C-Reactive Protein - metabolism</topic><topic>European Continental Ancestry Group</topic><topic>Female</topic><topic>Humans</topic><topic>Inflammation - blood</topic><topic>Inflammation - ethnology</topic><topic>Interleukin-6 - blood</topic><topic>Obesity - blood</topic><topic>Obesity - ethnology</topic><topic>Receptors, Tumor Necrosis Factor, Type I - blood</topic><topic>Receptors, Tumor Necrosis Factor, Type II - blood</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><topic>Weight Loss - ethnology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fisher, Gordon</creatorcontrib><creatorcontrib>Hyatt, Tanya C.</creatorcontrib><creatorcontrib>Hunter, Gary R.</creatorcontrib><creatorcontrib>Oster, Robert A.</creatorcontrib><creatorcontrib>Desmond, Renee A.</creatorcontrib><creatorcontrib>Gower, Barbara A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Obesity (Silver Spring, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fisher, Gordon</au><au>Hyatt, Tanya C.</au><au>Hunter, Gary R.</au><au>Oster, Robert A.</au><au>Desmond, Renee A.</au><au>Gower, Barbara A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Markers of Inflammation and Fat Distribution Following Weight Loss in African‐American and White Women</atitle><jtitle>Obesity (Silver Spring, Md.)</jtitle><addtitle>Obesity (Silver Spring)</addtitle><date>2012-04</date><risdate>2012</risdate><volume>20</volume><issue>4</issue><spage>715</spage><epage>720</epage><pages>715-720</pages><issn>1930-7381</issn><eissn>1930-739X</eissn><abstract>Changes in markers of inflammation (MOI) and fat distribution with weight loss between African‐American (AA) and white (W) women have yet to be characterized. The purpose of this study was to examine potential ethnic differences in MOI and regional fat distribution with weight loss, and identify the associations between these markers and changes in regional fat distribution with weight loss among AA and W women. Subjects were 126 healthy, premenopausal women, BMI 27–30 kg/m2. They were placed on a weight‐loss intervention consisting of diet and/or exercise until a BMI <25 was achieved. Fat distribution was measured with computed tomography, and body composition with dual‐energy X‐ray absorptiometry. Serum concentrations of tumor necrosis factor‐α (TNF‐α), soluble TNF receptor‐I (sTNFR‐I), sTNFR‐II, C‐reactive protein (CRP), and interleukin‐6 (IL‐6) were assessed. All MOI and adiposity measures significantly decreased with weight loss. Significant ethnic differences with weight loss were observed for fat mass, body fat, intra‐abdominal adipose tissue (IAAT), sTNFR‐I, and sTNFR‐II. Mixed‐model analysis indicated that adjusting for change in IAAT explained ethnic differences in change in TNF‐α and the decrease in TNF‐α with weight loss, while total fat mass only explained the decrease in sTNFR‐I and sTNFR‐II with weight loss. In conclusion, all MOI decreased following weight loss among W, whereas only IL‐6 and CRP decreased following weight loss in AA. The most distinct phenotypic difference observed was a greater impact of weight loss on TNF‐α in W compared to AA, which was directly associated with IAAT in W.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21527894</pmid><doi>10.1038/oby.2011.85</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Absorptiometry, Photon Adult African Americans Biomarkers - blood Body Composition Body Fat Distribution Body Mass Index C-Reactive Protein - metabolism European Continental Ancestry Group Female Humans Inflammation - blood Inflammation - ethnology Interleukin-6 - blood Obesity - blood Obesity - ethnology Receptors, Tumor Necrosis Factor, Type I - blood Receptors, Tumor Necrosis Factor, Type II - blood Tumor Necrosis Factor-alpha - blood Weight Loss - ethnology |
| title | Markers of Inflammation and Fat Distribution Following Weight Loss in African‐American and White Women |
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