Serum resistin is related to plasma HDL cholesterol and inversely correlated with LDL cholesterol in diabetic and obese humans
Plasma cholesterol, triglycerides and serum resisistin may all be influenced by diabetes and obesity, but their associations remain unclear. Therefore, we put forward a hypothesis that serum lipids might be parallel to resistin, as they all reflect the metabolic status of obese humans. We measured t...
Gespeichert in:
| Veröffentlicht in: | Neuro-endocrinology letters 2010, Vol.31 (5), p.673-678 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 678 |
|---|---|
| container_issue | 5 |
| container_start_page | 673 |
| container_title | Neuro-endocrinology letters |
| container_volume | 31 |
| creator | Owecki, Maciej Nikisch, Elżbieta Miczke, Anna Pupek-Musialik, Danuta Sowiński, Jerzy |
| description | Plasma cholesterol, triglycerides and serum resisistin may all be influenced by diabetes and obesity, but their associations remain unclear. Therefore, we put forward a hypothesis that serum lipids might be parallel to resistin, as they all reflect the metabolic status of obese humans.
We measured the concentrations of resistin, total cholesterol (TC), HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C) and triglycerides (TG) in 134 obese non-diabetic (73 women and 61 men) and 65 obese diabetic (33 women, 32 men) humans, and examined their interrelations. Obesity was defined according to the WHO criterion (BMI, ≥ 30 kg/m²) The presence of diabetes was the only differentiating factor between two groups of frankly obese humans.
Non-diabetic vs. diabetic, median and interquartile range, respectively: resistin (ng/mL) 26.08, 16.09 vs. 22.37, 14.54, p=0.736; TC (mmol/L) 5.02, 1.39 vs. 5.16, 1.56, p=0.374; HDL-C (mmol/L): 1.10, 0.41 vs. 1.02, 0.47 p |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_954680456</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>845399199</sourcerecordid><originalsourceid>FETCH-LOGICAL-p242t-7ca7700221f19a0a7b8e8109fd77968849fa2de29400c39be9377b4ba603dd543</originalsourceid><addsrcrecordid>eNqFkD1PwzAYhD2AaCn8BeSNKZK_EscjKh-tFIkBkNgiJ36jGjlxsB1QF347EbQLC9Pd8NzpdCdoSahkmSzJ6wKdx_hGCFM542dowSiVXAq6RF9PEKYeB4g2JjtgG2fvdAKDk8ej07HXeHNb4XbnHcQEwTusB4Pt8AEhgtvj1odj5NOmHa7-0HOrsbqBZNufpG8gAt5NvR7iBTrttItwedAVerm_e15vsurxYbu-qbKRCZYy2Wop5_mMdlRpomVTQkmJ6oyUqihLoTrNDDAlCGm5akBxKRvR6IJwY3LBV-j6t3cM_n2al9W9jS04pwfwU6xVLoqSiLz4lyxFzpWiSs3k1YGcmh5MPQbb67Cvj-fyb2NwdcI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>845399199</pqid></control><display><type>article</type><title>Serum resistin is related to plasma HDL cholesterol and inversely correlated with LDL cholesterol in diabetic and obese humans</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Owecki, Maciej ; Nikisch, Elżbieta ; Miczke, Anna ; Pupek-Musialik, Danuta ; Sowiński, Jerzy</creator><creatorcontrib>Owecki, Maciej ; Nikisch, Elżbieta ; Miczke, Anna ; Pupek-Musialik, Danuta ; Sowiński, Jerzy</creatorcontrib><description>Plasma cholesterol, triglycerides and serum resisistin may all be influenced by diabetes and obesity, but their associations remain unclear. Therefore, we put forward a hypothesis that serum lipids might be parallel to resistin, as they all reflect the metabolic status of obese humans.
We measured the concentrations of resistin, total cholesterol (TC), HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C) and triglycerides (TG) in 134 obese non-diabetic (73 women and 61 men) and 65 obese diabetic (33 women, 32 men) humans, and examined their interrelations. Obesity was defined according to the WHO criterion (BMI, ≥ 30 kg/m²) The presence of diabetes was the only differentiating factor between two groups of frankly obese humans.
Non-diabetic vs. diabetic, median and interquartile range, respectively: resistin (ng/mL) 26.08, 16.09 vs. 22.37, 14.54, p=0.736; TC (mmol/L) 5.02, 1.39 vs. 5.16, 1.56, p=0.374; HDL-C (mmol/L): 1.10, 0.41 vs. 1.02, 0.47 p<0.05; LDL-C (mmol/L): 3.00, 1.05 vs. 3.00, 1.30 p=0.978; TG (mmol/L) 1.70, 1.43 vs.1.95, 1.81 p<0.05. To investigate the interrelations between resistin and lipids, a simple regression analysis was used, and the results were for resistin & TC, HDL-C, LDL-C, and TG, respectively: in the whole cohort r=-0.1364, p=0.0670, r=0.1514, p=0.0437, r=-0.2573, p=0.0006, r=0.0434, p=0.5597; in non-diabetics: r=-0.2067, p=0.0213, r=0.1023, p=0.2621, r=-0.2399, p=0.0083 and r=0.0288, p=0.7497; in diabetics r=0.0280, p=0.8360, r=0.2267, p=0.0929, r=-0.2933, p=0.0298, r=0.1349, p=0.3127.
In diabetic and non-diabetic subjects the atherogenic LDL cholesterol shows an inverse correlation with resistin, whereas the protective anti-atherosclerotic HDL cholesterol is positively correlated with resistin.</description><identifier>ISSN: 0172-780X</identifier><identifier>PMID: 21173741</identifier><language>eng</language><publisher>Sweden</publisher><subject>Aged ; Biomarkers - blood ; Body Mass Index ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Comorbidity ; Diabetes Mellitus - blood ; Diabetes Mellitus - diagnosis ; Diabetes Mellitus - epidemiology ; Female ; Humans ; Male ; Middle Aged ; Obesity - blood ; Obesity - diagnosis ; Obesity - epidemiology ; Poland - epidemiology ; Regression Analysis ; Resistin - blood ; Triglycerides - blood</subject><ispartof>Neuro-endocrinology letters, 2010, Vol.31 (5), p.673-678</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4009</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21173741$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Owecki, Maciej</creatorcontrib><creatorcontrib>Nikisch, Elżbieta</creatorcontrib><creatorcontrib>Miczke, Anna</creatorcontrib><creatorcontrib>Pupek-Musialik, Danuta</creatorcontrib><creatorcontrib>Sowiński, Jerzy</creatorcontrib><title>Serum resistin is related to plasma HDL cholesterol and inversely correlated with LDL cholesterol in diabetic and obese humans</title><title>Neuro-endocrinology letters</title><addtitle>Neuro Endocrinol Lett</addtitle><description>Plasma cholesterol, triglycerides and serum resisistin may all be influenced by diabetes and obesity, but their associations remain unclear. Therefore, we put forward a hypothesis that serum lipids might be parallel to resistin, as they all reflect the metabolic status of obese humans.
We measured the concentrations of resistin, total cholesterol (TC), HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C) and triglycerides (TG) in 134 obese non-diabetic (73 women and 61 men) and 65 obese diabetic (33 women, 32 men) humans, and examined their interrelations. Obesity was defined according to the WHO criterion (BMI, ≥ 30 kg/m²) The presence of diabetes was the only differentiating factor between two groups of frankly obese humans.
Non-diabetic vs. diabetic, median and interquartile range, respectively: resistin (ng/mL) 26.08, 16.09 vs. 22.37, 14.54, p=0.736; TC (mmol/L) 5.02, 1.39 vs. 5.16, 1.56, p=0.374; HDL-C (mmol/L): 1.10, 0.41 vs. 1.02, 0.47 p<0.05; LDL-C (mmol/L): 3.00, 1.05 vs. 3.00, 1.30 p=0.978; TG (mmol/L) 1.70, 1.43 vs.1.95, 1.81 p<0.05. To investigate the interrelations between resistin and lipids, a simple regression analysis was used, and the results were for resistin & TC, HDL-C, LDL-C, and TG, respectively: in the whole cohort r=-0.1364, p=0.0670, r=0.1514, p=0.0437, r=-0.2573, p=0.0006, r=0.0434, p=0.5597; in non-diabetics: r=-0.2067, p=0.0213, r=0.1023, p=0.2621, r=-0.2399, p=0.0083 and r=0.0288, p=0.7497; in diabetics r=0.0280, p=0.8360, r=0.2267, p=0.0929, r=-0.2933, p=0.0298, r=0.1349, p=0.3127.
In diabetic and non-diabetic subjects the atherogenic LDL cholesterol shows an inverse correlation with resistin, whereas the protective anti-atherosclerotic HDL cholesterol is positively correlated with resistin.</description><subject>Aged</subject><subject>Biomarkers - blood</subject><subject>Body Mass Index</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Comorbidity</subject><subject>Diabetes Mellitus - blood</subject><subject>Diabetes Mellitus - diagnosis</subject><subject>Diabetes Mellitus - epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Obesity - blood</subject><subject>Obesity - diagnosis</subject><subject>Obesity - epidemiology</subject><subject>Poland - epidemiology</subject><subject>Regression Analysis</subject><subject>Resistin - blood</subject><subject>Triglycerides - blood</subject><issn>0172-780X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkD1PwzAYhD2AaCn8BeSNKZK_EscjKh-tFIkBkNgiJ36jGjlxsB1QF347EbQLC9Pd8NzpdCdoSahkmSzJ6wKdx_hGCFM542dowSiVXAq6RF9PEKYeB4g2JjtgG2fvdAKDk8ej07HXeHNb4XbnHcQEwTusB4Pt8AEhgtvj1odj5NOmHa7-0HOrsbqBZNufpG8gAt5NvR7iBTrttItwedAVerm_e15vsurxYbu-qbKRCZYy2Wop5_mMdlRpomVTQkmJ6oyUqihLoTrNDDAlCGm5akBxKRvR6IJwY3LBV-j6t3cM_n2al9W9jS04pwfwU6xVLoqSiLz4lyxFzpWiSs3k1YGcmh5MPQbb67Cvj-fyb2NwdcI</recordid><startdate>2010</startdate><enddate>2010</enddate><creator>Owecki, Maciej</creator><creator>Nikisch, Elżbieta</creator><creator>Miczke, Anna</creator><creator>Pupek-Musialik, Danuta</creator><creator>Sowiński, Jerzy</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>2010</creationdate><title>Serum resistin is related to plasma HDL cholesterol and inversely correlated with LDL cholesterol in diabetic and obese humans</title><author>Owecki, Maciej ; Nikisch, Elżbieta ; Miczke, Anna ; Pupek-Musialik, Danuta ; Sowiński, Jerzy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p242t-7ca7700221f19a0a7b8e8109fd77968849fa2de29400c39be9377b4ba603dd543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aged</topic><topic>Biomarkers - blood</topic><topic>Body Mass Index</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>Comorbidity</topic><topic>Diabetes Mellitus - blood</topic><topic>Diabetes Mellitus - diagnosis</topic><topic>Diabetes Mellitus - epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Obesity - blood</topic><topic>Obesity - diagnosis</topic><topic>Obesity - epidemiology</topic><topic>Poland - epidemiology</topic><topic>Regression Analysis</topic><topic>Resistin - blood</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Owecki, Maciej</creatorcontrib><creatorcontrib>Nikisch, Elżbieta</creatorcontrib><creatorcontrib>Miczke, Anna</creatorcontrib><creatorcontrib>Pupek-Musialik, Danuta</creatorcontrib><creatorcontrib>Sowiński, Jerzy</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuro-endocrinology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Owecki, Maciej</au><au>Nikisch, Elżbieta</au><au>Miczke, Anna</au><au>Pupek-Musialik, Danuta</au><au>Sowiński, Jerzy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum resistin is related to plasma HDL cholesterol and inversely correlated with LDL cholesterol in diabetic and obese humans</atitle><jtitle>Neuro-endocrinology letters</jtitle><addtitle>Neuro Endocrinol Lett</addtitle><date>2010</date><risdate>2010</risdate><volume>31</volume><issue>5</issue><spage>673</spage><epage>678</epage><pages>673-678</pages><issn>0172-780X</issn><abstract>Plasma cholesterol, triglycerides and serum resisistin may all be influenced by diabetes and obesity, but their associations remain unclear. Therefore, we put forward a hypothesis that serum lipids might be parallel to resistin, as they all reflect the metabolic status of obese humans.
We measured the concentrations of resistin, total cholesterol (TC), HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C) and triglycerides (TG) in 134 obese non-diabetic (73 women and 61 men) and 65 obese diabetic (33 women, 32 men) humans, and examined their interrelations. Obesity was defined according to the WHO criterion (BMI, ≥ 30 kg/m²) The presence of diabetes was the only differentiating factor between two groups of frankly obese humans.
Non-diabetic vs. diabetic, median and interquartile range, respectively: resistin (ng/mL) 26.08, 16.09 vs. 22.37, 14.54, p=0.736; TC (mmol/L) 5.02, 1.39 vs. 5.16, 1.56, p=0.374; HDL-C (mmol/L): 1.10, 0.41 vs. 1.02, 0.47 p<0.05; LDL-C (mmol/L): 3.00, 1.05 vs. 3.00, 1.30 p=0.978; TG (mmol/L) 1.70, 1.43 vs.1.95, 1.81 p<0.05. To investigate the interrelations between resistin and lipids, a simple regression analysis was used, and the results were for resistin & TC, HDL-C, LDL-C, and TG, respectively: in the whole cohort r=-0.1364, p=0.0670, r=0.1514, p=0.0437, r=-0.2573, p=0.0006, r=0.0434, p=0.5597; in non-diabetics: r=-0.2067, p=0.0213, r=0.1023, p=0.2621, r=-0.2399, p=0.0083 and r=0.0288, p=0.7497; in diabetics r=0.0280, p=0.8360, r=0.2267, p=0.0929, r=-0.2933, p=0.0298, r=0.1349, p=0.3127.
In diabetic and non-diabetic subjects the atherogenic LDL cholesterol shows an inverse correlation with resistin, whereas the protective anti-atherosclerotic HDL cholesterol is positively correlated with resistin.</abstract><cop>Sweden</cop><pmid>21173741</pmid><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0172-780X |
| ispartof | Neuro-endocrinology letters, 2010, Vol.31 (5), p.673-678 |
| issn | 0172-780X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_954680456 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Aged Biomarkers - blood Body Mass Index Cholesterol, HDL - blood Cholesterol, LDL - blood Comorbidity Diabetes Mellitus - blood Diabetes Mellitus - diagnosis Diabetes Mellitus - epidemiology Female Humans Male Middle Aged Obesity - blood Obesity - diagnosis Obesity - epidemiology Poland - epidemiology Regression Analysis Resistin - blood Triglycerides - blood |
| title | Serum resistin is related to plasma HDL cholesterol and inversely correlated with LDL cholesterol in diabetic and obese humans |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T19%3A05%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Serum%20resistin%20is%20related%20to%20plasma%20HDL%20cholesterol%20and%20inversely%20correlated%20with%20LDL%20cholesterol%20in%20diabetic%20and%20obese%20humans&rft.jtitle=Neuro-endocrinology%20letters&rft.au=Owecki,%20Maciej&rft.date=2010&rft.volume=31&rft.issue=5&rft.spage=673&rft.epage=678&rft.pages=673-678&rft.issn=0172-780X&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E845399199%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=845399199&rft_id=info:pmid/21173741&rfr_iscdi=true |