Curcumin protects mice against concanavalin A-induced hepatitis by inhibiting intrahepatic intercellular adhesion molecule-1 (ICAM-1) and CXCL10 expression
The effect of curcumin on liver injury caused by Concanavalin A (Con A) has not been carefully examined. This study was designed to evaluate the protective effect of curcumin on Con A-induced hepatitis in mice. Liver injured mice received curcumin by gavage at a dose of 200 mg/kg body weight before...
Gespeichert in:
| Veröffentlicht in: | Molecular and cellular biochemistry 2011-12, Vol.358 (1-2), p.53-60 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 60 |
|---|---|
| container_issue | 1-2 |
| container_start_page | 53 |
| container_title | Molecular and cellular biochemistry |
| container_volume | 358 |
| creator | Tu, Chuan-tao Han, Bing Liu, Hong-chun Zhang, Shun-cai |
| description | The effect of curcumin on liver injury caused by Concanavalin A (Con A) has not been carefully examined. This study was designed to evaluate the protective effect of curcumin on Con A-induced hepatitis in mice. Liver injured mice received curcumin by gavage at a dose of 200 mg/kg body weight before Con A intravenous administration. Curcumin was effective in reducing the elevated plasma levels of aminotransferases and the incidence of liver necrosis compared with Con A-injected control group. Enzyme-linked immunosorbent assay (ELISA) showed that curcumin suppressed proinflammatory cytokines such as tumor necrosis factor (TNF)-α, interferon (IFN)-γ, and interleukin (IL)-4 production in Con A-injected mice. The reduced severity of hepatitis in curcumin pretreated mice correlated with decrease in numbers of liver CD4
+
T cells but not CD8
+
T cells by immunohistochemical analysis. Furthermore, the expression levels of intercellular adhesion molecule-1 (ICAM-1) and the interferon-inducible chemokine CXCL10 in hepatic tissue were significantly decreased by curcumin pretreatment. In conclusion, curcumin pretreatment protects against T cell-mediated hepatitis in mice. |
| doi_str_mv | 10.1007/s11010-011-0920-4 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_954664660</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A359411149</galeid><sourcerecordid>A359411149</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4504-e1107b822ca5283a221ce3b3ed2da7fe9460976d991167564858a126c06d11fc3</originalsourceid><addsrcrecordid>eNp1kk1v1DAQhiMEotvCD-CCLDgABxeP8-H1cRVRQFrEBSRuluNMdl0lzmInFf0t_FkmSgGBQLbkr-cdjd-ZLHsC4hKEUK8TgADBBQAXWgpe3Ms2UKqcFxr0_WwjciH4FpQ6y85TuhYEE_swO5NQ6bKoYJN9r-fo5sEHdorjhG5KbPAOmT1YH9LE3BicDfbG9oTsuA_t7LBlRzzZyU8-seaW-XD0DR3CgbZTtOujWw4YHfb93NvIbHvE5MfAhrFHN_fIgb18X-8-cHjFbGhZ_aXeg2D47RQxLeSj7EFn-4SP79aL7PPVm0_1O77_-JaEe-6KUhQcyQXVbKV0tpTb3EoJDvMmx1a2VnWoi0poVbVaA1SqrIptubUgKyeqFqBz-UX2Yo1LFnydMU1m8GnJ2wYc52QWqyqagshnf5HX4xwDJWc0FUSR1Yqg5yt0sD0aH7qRPHFLSLPLS10AQKGJuvwHRaNFKsAYsPN0_4cAVoGLY0oRO3OKfrDx1oAwSzuYtR0Mldgs7WAK0jy9y3duBmx_KX7WnwC5AomewgHj7w_9P-oP97G96A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>900771777</pqid></control><display><type>article</type><title>Curcumin protects mice against concanavalin A-induced hepatitis by inhibiting intrahepatic intercellular adhesion molecule-1 (ICAM-1) and CXCL10 expression</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Tu, Chuan-tao ; Han, Bing ; Liu, Hong-chun ; Zhang, Shun-cai</creator><creatorcontrib>Tu, Chuan-tao ; Han, Bing ; Liu, Hong-chun ; Zhang, Shun-cai</creatorcontrib><description>The effect of curcumin on liver injury caused by Concanavalin A (Con A) has not been carefully examined. This study was designed to evaluate the protective effect of curcumin on Con A-induced hepatitis in mice. Liver injured mice received curcumin by gavage at a dose of 200 mg/kg body weight before Con A intravenous administration. Curcumin was effective in reducing the elevated plasma levels of aminotransferases and the incidence of liver necrosis compared with Con A-injected control group. Enzyme-linked immunosorbent assay (ELISA) showed that curcumin suppressed proinflammatory cytokines such as tumor necrosis factor (TNF)-α, interferon (IFN)-γ, and interleukin (IL)-4 production in Con A-injected mice. The reduced severity of hepatitis in curcumin pretreated mice correlated with decrease in numbers of liver CD4
+
T cells but not CD8
+
T cells by immunohistochemical analysis. Furthermore, the expression levels of intercellular adhesion molecule-1 (ICAM-1) and the interferon-inducible chemokine CXCL10 in hepatic tissue were significantly decreased by curcumin pretreatment. In conclusion, curcumin pretreatment protects against T cell-mediated hepatitis in mice.</description><identifier>ISSN: 0300-8177</identifier><identifier>EISSN: 1573-4919</identifier><identifier>DOI: 10.1007/s11010-011-0920-4</identifier><identifier>PMID: 21695461</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adhesion ; Alanine Transaminase - blood ; Animals ; Aspartate Aminotransferases - blood ; Biochemistry ; Biological response modifiers ; Biomedical and Life Sciences ; Body weight ; Cardiology ; CD4 antigen ; CD4-Positive T-Lymphocytes - drug effects ; CD8 antigen ; CD8-Positive T-Lymphocytes - drug effects ; Cell adhesion & migration ; Cell Movement - drug effects ; Chemokine CXCL10 - genetics ; Chemokine CXCL10 - metabolism ; Chemokines ; Comparative analysis ; Concanavalin A ; Curcumin ; Curcumin - pharmacology ; Curcumin - therapeutic use ; CXCL10 protein ; Cytokines - metabolism ; Enzyme-linked immunosorbent assay ; Gene expression ; Gene Expression Regulation - drug effects ; Hepatitis ; Hepatitis - blood ; Hepatitis - drug therapy ; Hepatitis - pathology ; Hepatitis - prevention & control ; Hepatocytes ; Inflammation ; Injuries ; intercellular adhesion molecule 1 ; Intercellular Adhesion Molecule-1 - genetics ; Intercellular Adhesion Molecule-1 - metabolism ; Interferon ; Interleukins ; Intravenous administration ; Life Sciences ; Liver ; Liver - drug effects ; Liver - metabolism ; Liver - pathology ; Lymphocytes ; Lymphocytes T ; Male ; Medical Biochemistry ; Mice ; Mice, Inbred BALB C ; Mitogens ; Molecular biology ; Oncology ; Plasma levels ; Protective Agents - therapeutic use ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Rodents ; T cells ; Tumor necrosis factor</subject><ispartof>Molecular and cellular biochemistry, 2011-12, Vol.358 (1-2), p.53-60</ispartof><rights>Springer Science+Business Media, LLC. 2011</rights><rights>COPYRIGHT 2011 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4504-e1107b822ca5283a221ce3b3ed2da7fe9460976d991167564858a126c06d11fc3</citedby><cites>FETCH-LOGICAL-c4504-e1107b822ca5283a221ce3b3ed2da7fe9460976d991167564858a126c06d11fc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11010-011-0920-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11010-011-0920-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21695461$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tu, Chuan-tao</creatorcontrib><creatorcontrib>Han, Bing</creatorcontrib><creatorcontrib>Liu, Hong-chun</creatorcontrib><creatorcontrib>Zhang, Shun-cai</creatorcontrib><title>Curcumin protects mice against concanavalin A-induced hepatitis by inhibiting intrahepatic intercellular adhesion molecule-1 (ICAM-1) and CXCL10 expression</title><title>Molecular and cellular biochemistry</title><addtitle>Mol Cell Biochem</addtitle><addtitle>Mol Cell Biochem</addtitle><description>The effect of curcumin on liver injury caused by Concanavalin A (Con A) has not been carefully examined. This study was designed to evaluate the protective effect of curcumin on Con A-induced hepatitis in mice. Liver injured mice received curcumin by gavage at a dose of 200 mg/kg body weight before Con A intravenous administration. Curcumin was effective in reducing the elevated plasma levels of aminotransferases and the incidence of liver necrosis compared with Con A-injected control group. Enzyme-linked immunosorbent assay (ELISA) showed that curcumin suppressed proinflammatory cytokines such as tumor necrosis factor (TNF)-α, interferon (IFN)-γ, and interleukin (IL)-4 production in Con A-injected mice. The reduced severity of hepatitis in curcumin pretreated mice correlated with decrease in numbers of liver CD4
+
T cells but not CD8
+
T cells by immunohistochemical analysis. Furthermore, the expression levels of intercellular adhesion molecule-1 (ICAM-1) and the interferon-inducible chemokine CXCL10 in hepatic tissue were significantly decreased by curcumin pretreatment. In conclusion, curcumin pretreatment protects against T cell-mediated hepatitis in mice.</description><subject>Adhesion</subject><subject>Alanine Transaminase - blood</subject><subject>Animals</subject><subject>Aspartate Aminotransferases - blood</subject><subject>Biochemistry</subject><subject>Biological response modifiers</subject><subject>Biomedical and Life Sciences</subject><subject>Body weight</subject><subject>Cardiology</subject><subject>CD4 antigen</subject><subject>CD4-Positive T-Lymphocytes - drug effects</subject><subject>CD8 antigen</subject><subject>CD8-Positive T-Lymphocytes - drug effects</subject><subject>Cell adhesion & migration</subject><subject>Cell Movement - drug effects</subject><subject>Chemokine CXCL10 - genetics</subject><subject>Chemokine CXCL10 - metabolism</subject><subject>Chemokines</subject><subject>Comparative analysis</subject><subject>Concanavalin A</subject><subject>Curcumin</subject><subject>Curcumin - pharmacology</subject><subject>Curcumin - therapeutic use</subject><subject>CXCL10 protein</subject><subject>Cytokines - metabolism</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Gene expression</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Hepatitis</subject><subject>Hepatitis - blood</subject><subject>Hepatitis - drug therapy</subject><subject>Hepatitis - pathology</subject><subject>Hepatitis - prevention & control</subject><subject>Hepatocytes</subject><subject>Inflammation</subject><subject>Injuries</subject><subject>intercellular adhesion molecule 1</subject><subject>Intercellular Adhesion Molecule-1 - genetics</subject><subject>Intercellular Adhesion Molecule-1 - metabolism</subject><subject>Interferon</subject><subject>Interleukins</subject><subject>Intravenous administration</subject><subject>Life Sciences</subject><subject>Liver</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Liver - pathology</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Male</subject><subject>Medical Biochemistry</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mitogens</subject><subject>Molecular biology</subject><subject>Oncology</subject><subject>Plasma levels</subject><subject>Protective Agents - therapeutic use</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Rodents</subject><subject>T cells</subject><subject>Tumor necrosis factor</subject><issn>0300-8177</issn><issn>1573-4919</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kk1v1DAQhiMEotvCD-CCLDgABxeP8-H1cRVRQFrEBSRuluNMdl0lzmInFf0t_FkmSgGBQLbkr-cdjd-ZLHsC4hKEUK8TgADBBQAXWgpe3Ms2UKqcFxr0_WwjciH4FpQ6y85TuhYEE_swO5NQ6bKoYJN9r-fo5sEHdorjhG5KbPAOmT1YH9LE3BicDfbG9oTsuA_t7LBlRzzZyU8-seaW-XD0DR3CgbZTtOujWw4YHfb93NvIbHvE5MfAhrFHN_fIgb18X-8-cHjFbGhZ_aXeg2D47RQxLeSj7EFn-4SP79aL7PPVm0_1O77_-JaEe-6KUhQcyQXVbKV0tpTb3EoJDvMmx1a2VnWoi0poVbVaA1SqrIptubUgKyeqFqBz-UX2Yo1LFnydMU1m8GnJ2wYc52QWqyqagshnf5HX4xwDJWc0FUSR1Yqg5yt0sD0aH7qRPHFLSLPLS10AQKGJuvwHRaNFKsAYsPN0_4cAVoGLY0oRO3OKfrDx1oAwSzuYtR0Mldgs7WAK0jy9y3duBmx_KX7WnwC5AomewgHj7w_9P-oP97G96A</recordid><startdate>20111201</startdate><enddate>20111201</enddate><creator>Tu, Chuan-tao</creator><creator>Han, Bing</creator><creator>Liu, Hong-chun</creator><creator>Zhang, Shun-cai</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope></search><sort><creationdate>20111201</creationdate><title>Curcumin protects mice against concanavalin A-induced hepatitis by inhibiting intrahepatic intercellular adhesion molecule-1 (ICAM-1) and CXCL10 expression</title><author>Tu, Chuan-tao ; Han, Bing ; Liu, Hong-chun ; Zhang, Shun-cai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4504-e1107b822ca5283a221ce3b3ed2da7fe9460976d991167564858a126c06d11fc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adhesion</topic><topic>Alanine Transaminase - blood</topic><topic>Animals</topic><topic>Aspartate Aminotransferases - blood</topic><topic>Biochemistry</topic><topic>Biological response modifiers</topic><topic>Biomedical and Life Sciences</topic><topic>Body weight</topic><topic>Cardiology</topic><topic>CD4 antigen</topic><topic>CD4-Positive T-Lymphocytes - drug effects</topic><topic>CD8 antigen</topic><topic>CD8-Positive T-Lymphocytes - drug effects</topic><topic>Cell adhesion & migration</topic><topic>Cell Movement - drug effects</topic><topic>Chemokine CXCL10 - genetics</topic><topic>Chemokine CXCL10 - metabolism</topic><topic>Chemokines</topic><topic>Comparative analysis</topic><topic>Concanavalin A</topic><topic>Curcumin</topic><topic>Curcumin - pharmacology</topic><topic>Curcumin - therapeutic use</topic><topic>CXCL10 protein</topic><topic>Cytokines - metabolism</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Gene expression</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Hepatitis</topic><topic>Hepatitis - blood</topic><topic>Hepatitis - drug therapy</topic><topic>Hepatitis - pathology</topic><topic>Hepatitis - prevention & control</topic><topic>Hepatocytes</topic><topic>Inflammation</topic><topic>Injuries</topic><topic>intercellular adhesion molecule 1</topic><topic>Intercellular Adhesion Molecule-1 - genetics</topic><topic>Intercellular Adhesion Molecule-1 - metabolism</topic><topic>Interferon</topic><topic>Interleukins</topic><topic>Intravenous administration</topic><topic>Life Sciences</topic><topic>Liver</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Liver - pathology</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Male</topic><topic>Medical Biochemistry</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mitogens</topic><topic>Molecular biology</topic><topic>Oncology</topic><topic>Plasma levels</topic><topic>Protective Agents - therapeutic use</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Rodents</topic><topic>T cells</topic><topic>Tumor necrosis factor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tu, Chuan-tao</creatorcontrib><creatorcontrib>Han, Bing</creatorcontrib><creatorcontrib>Liu, Hong-chun</creatorcontrib><creatorcontrib>Zhang, Shun-cai</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><jtitle>Molecular and cellular biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tu, Chuan-tao</au><au>Han, Bing</au><au>Liu, Hong-chun</au><au>Zhang, Shun-cai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Curcumin protects mice against concanavalin A-induced hepatitis by inhibiting intrahepatic intercellular adhesion molecule-1 (ICAM-1) and CXCL10 expression</atitle><jtitle>Molecular and cellular biochemistry</jtitle><stitle>Mol Cell Biochem</stitle><addtitle>Mol Cell Biochem</addtitle><date>2011-12-01</date><risdate>2011</risdate><volume>358</volume><issue>1-2</issue><spage>53</spage><epage>60</epage><pages>53-60</pages><issn>0300-8177</issn><eissn>1573-4919</eissn><abstract>The effect of curcumin on liver injury caused by Concanavalin A (Con A) has not been carefully examined. This study was designed to evaluate the protective effect of curcumin on Con A-induced hepatitis in mice. Liver injured mice received curcumin by gavage at a dose of 200 mg/kg body weight before Con A intravenous administration. Curcumin was effective in reducing the elevated plasma levels of aminotransferases and the incidence of liver necrosis compared with Con A-injected control group. Enzyme-linked immunosorbent assay (ELISA) showed that curcumin suppressed proinflammatory cytokines such as tumor necrosis factor (TNF)-α, interferon (IFN)-γ, and interleukin (IL)-4 production in Con A-injected mice. The reduced severity of hepatitis in curcumin pretreated mice correlated with decrease in numbers of liver CD4
+
T cells but not CD8
+
T cells by immunohistochemical analysis. Furthermore, the expression levels of intercellular adhesion molecule-1 (ICAM-1) and the interferon-inducible chemokine CXCL10 in hepatic tissue were significantly decreased by curcumin pretreatment. In conclusion, curcumin pretreatment protects against T cell-mediated hepatitis in mice.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>21695461</pmid><doi>10.1007/s11010-011-0920-4</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-8177 |
| ispartof | Molecular and cellular biochemistry, 2011-12, Vol.358 (1-2), p.53-60 |
| issn | 0300-8177 1573-4919 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_954664660 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adhesion Alanine Transaminase - blood Animals Aspartate Aminotransferases - blood Biochemistry Biological response modifiers Biomedical and Life Sciences Body weight Cardiology CD4 antigen CD4-Positive T-Lymphocytes - drug effects CD8 antigen CD8-Positive T-Lymphocytes - drug effects Cell adhesion & migration Cell Movement - drug effects Chemokine CXCL10 - genetics Chemokine CXCL10 - metabolism Chemokines Comparative analysis Concanavalin A Curcumin Curcumin - pharmacology Curcumin - therapeutic use CXCL10 protein Cytokines - metabolism Enzyme-linked immunosorbent assay Gene expression Gene Expression Regulation - drug effects Hepatitis Hepatitis - blood Hepatitis - drug therapy Hepatitis - pathology Hepatitis - prevention & control Hepatocytes Inflammation Injuries intercellular adhesion molecule 1 Intercellular Adhesion Molecule-1 - genetics Intercellular Adhesion Molecule-1 - metabolism Interferon Interleukins Intravenous administration Life Sciences Liver Liver - drug effects Liver - metabolism Liver - pathology Lymphocytes Lymphocytes T Male Medical Biochemistry Mice Mice, Inbred BALB C Mitogens Molecular biology Oncology Plasma levels Protective Agents - therapeutic use RNA, Messenger - genetics RNA, Messenger - metabolism Rodents T cells Tumor necrosis factor |
| title | Curcumin protects mice against concanavalin A-induced hepatitis by inhibiting intrahepatic intercellular adhesion molecule-1 (ICAM-1) and CXCL10 expression |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T19%3A36%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Curcumin%20protects%20mice%20against%20concanavalin%20A-induced%20hepatitis%20by%20inhibiting%20intrahepatic%20intercellular%20adhesion%20molecule-1%20(ICAM-1)%20and%20CXCL10%20expression&rft.jtitle=Molecular%20and%20cellular%20biochemistry&rft.au=Tu,%20Chuan-tao&rft.date=2011-12-01&rft.volume=358&rft.issue=1-2&rft.spage=53&rft.epage=60&rft.pages=53-60&rft.issn=0300-8177&rft.eissn=1573-4919&rft_id=info:doi/10.1007/s11010-011-0920-4&rft_dat=%3Cgale_proqu%3EA359411149%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=900771777&rft_id=info:pmid/21695461&rft_galeid=A359411149&rfr_iscdi=true |