Role of retroviral restriction factors in the interferon-α–mediated suppression of HIV-1 in vivo

The antiviral potency of the cytokine IFN-α has been long appreciated but remains poorly understood. A number of studies have suggested that induction of the apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3 (APOBEC3) and bone marrow stromal cell antigen 2 (BST-2/tetherin/CD317) retrovir...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2012-02, Vol.109 (8), p.3035-3040
Hauptverfasser:	Pillai, Satish K, Abdel-Mohsen, Mohamed, Guatelli, John, Skasko, Mark, Monto, Alexander, Fujimoto, Katsuya, Yukl, Steven, Greene, Warner C, Kovari, Helen, Rauch, Andri, Fellay, Jacques, Battegay, Manuel, Hirschel, Bernard, Witteck, Andrea, Bernasconi, Enos, Ledergerber, Bruno, Günthard, Huldrych F, Wong, Joseph K
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha -Interferon Amino Acid Sequence antigens Antigens, CD - genetics Antigens, CD - metabolism Antiretrovirals Antiviral agents antiviral properties Antivirals APOBEC-3G Deaminase Apolipoprotein B Biological Sciences Bone marrow bone marrow cells CD4 antigen CD4-positive T-lymphocytes CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - metabolism CD4-Positive T-Lymphocytes - virology Cytidine Deaminase - genetics Cytidine Deaminase - metabolism Cytokines Cytosine Deaminase - genetics Cytosine Deaminase - metabolism Data processing drug therapy Enzymes Evolution Evolution, Molecular Gene expression Genetic mutation GPI-Linked Proteins - genetics GPI-Linked Proteins - metabolism Hepatitis C virus HIV HIV 1 HIV infections HIV-1 - drug effects Human immunodeficiency virus 1 Human Immunodeficiency Virus Proteins - chemistry Human Immunodeficiency Virus Proteins - metabolism Humans Infections interferon-alpha Interferon-alpha - pharmacology Lymphocytes T Messenger RNA Molecular Sequence Data Mutation - genetics Replication Ribavirin Ribavirin - pharmacology RNA editing stromal cells T lymphocytes Viral load viral proteins Viral Regulatory and Accessory Proteins - chemistry Viral Regulatory and Accessory Proteins - metabolism Viremia - immunology Viremia - virology virus replication Viruses
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