GABAergic control of novelty stress-responsive epigenetic and gene expression mechanisms in the rat dentate gyrus

Abstract The activity of dentate gyrus granule neurons is under a strong GABAergic tonic inhibitory control which contributes to the sparse activation pattern of these neurons after environmental stimuli. Previously, we reported that in sparse dentate gyrus neurons such stimuli evoke Ser-10 (S10) ph...

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Veröffentlicht in:	European neuropsychopharmacology 2011-04, Vol.21 (4), p.316-324
Hauptverfasser:	Papadopoulos, Andreas, Chandramohan, Yalini, Collins, Andrew, Droste, Susanne K, Nutt, David J, Reul, Johannes M.H.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Acetylation - drug effects Animals Anti-Anxiety Agents - administration & dosage Anti-Anxiety Agents - therapeutic use Anxiety Anxiety - chemically induced Anxiety - drug therapy Anxiety - metabolism Anxiolytics Behavior, Animal - drug effects c-Fos c-Fos protein Cell Count Chromatin Dentate gyrus Dentate Gyrus - drug effects Dentate Gyrus - metabolism Dentate Gyrus - pathology Dose-Response Relationship, Drug Drug Inverse Agonism Drugs Environmental effects epigenetics Exploratory Behavior - drug effects GABA GABA-A Receptor Agonists - administration & dosage GABA-A Receptor Agonists - therapeutic use gamma -Aminobutyric acid gamma -Aminobutyric acid A receptors gamma-Aminobutyric Acid - metabolism Gene expression Glucocorticoid Glutamic acid receptors (ionotropic) Granule cells Histone Histone H3 Histones - metabolism Internal Medicine Lorazepam Male Memory MK-801 N-Methyl-D-aspartic acid receptors Neuromodulation Neurons Neurons - drug effects Neurons - metabolism NMDA Novelty Phosphorylation Phosphorylation - drug effects Post-traumatic stress disorder Protein Processing, Post-Translational - drug effects Proto-Oncogene Proteins c-fos - metabolism Psychiatry Rats Rats, Wistar Receptor mechanisms Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Stress Stress, Psychological - drug therapy Stress, Psychological - metabolism
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