Polymorphisms in ABLIM1 are Associated with Personality Traits and Alcohol Dependence

Personality traits like novelty seeking (NS), harm avoidance (HA), and reward dependence (RD) are known to be moderately heritable (30–60%). These personality traits and their comorbidities, such as alcohol dependence (AD), may share genetic components. We examined 11,120 single nucleotide polymorph...

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Veröffentlicht in:	Journal of molecular neuroscience 2012-02, Vol.46 (2), p.265-271
Hauptverfasser:	Wang, Ke-Sheng, Liu, Xuefeng, Aragam, Nagesh, Mullersman, Jerald E., Jian, Xueqiu, Pan, Yue, Liu, Yali
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcoholism Alcoholism - genetics Association analysis Biomedical and Life Sciences Biomedicine Case-Control Studies Cell Biology chromosome 10 Cohort Studies Collaboration Conferences Drug abuse Drug dependence European Continental Ancestry Group - genetics Exploratory Behavior Family Female Gene loci Genetic analysis Genetic Association Studies Genetics Genomes Genotype Humans LIM Domain Proteins - genetics LIM Domain Proteins - physiology Male Microfilament Proteins - genetics Microfilament Proteins - physiology Nervous system Neurochemistry Neurology Neurosciences Nuclear family Personality Personality - genetics Personality Inventory Personality traits Polymorphism, Single Nucleotide Proteomics Reinforcement Replication Reward Sample Size Single-nucleotide polymorphism Surveys and Questionnaires United States White people
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Zusammenfassung:	Personality traits like novelty seeking (NS), harm avoidance (HA), and reward dependence (RD) are known to be moderately heritable (30–60%). These personality traits and their comorbidities, such as alcohol dependence (AD), may share genetic components. We examined 11,120 single nucleotide polymorphisms (SNPs) genotyped in 292 nuclear families from the Genetic Analysis Workshop 14, a subset from the Collaborative Study on the Genetics of Alcoholism (COGA). A family-based association analysis was performed using the FBAT program. NS, HA, and RD were treated as quantitative traits and AD as a binary trait. Based on a multivariate association test of three quantitative traits in FBAT, we observed 20 SNPs with p
ISSN:	0895-8696 1559-1166
DOI:	10.1007/s12031-011-9530-6