Prevalence of extended-spectrum cephalosporinase (ESC)-producing Escherichia coli in Danish slaughter pigs and retail meat identified by selective enrichment and association with cephalosporin usage
Objectives To investigate the prevalence of extended-spectrum cephalosporinase (ESC)-producing Escherichia coli in pigs at slaughter and retail meat, and possible associations with the consumption of third- and fourth-generation cephalosporins. Methods During 2009, faecal samples from Danish pigs (n...
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creator | Agersø, Yvonne Aarestrup, Frank M. Pedersen, Karl Seyfarth, Anne Mette Struve, Tina Hasman, Henrik |
description | Objectives
To investigate the prevalence of extended-spectrum cephalosporinase (ESC)-producing Escherichia coli in pigs at slaughter and retail meat, and possible associations with the consumption of third- and fourth-generation cephalosporins.
Methods
During 2009, faecal samples from Danish pigs (n = 786) were collected at slaughter, and 866 meat samples [Danish: pork (153), broiler meat (121) and beef (142); and imported: pork (173), broiler meat (193) and beef (84)] were randomly collected in retail stores and outlets. E. coli was isolated after enrichment in MacConkey broth with ceftriaxone (1 mg/L). ESC genotypes were detected using PCR, microtube array and sequencing. The MIC of cefotaxime was determined for 150 E. coli from the pigs and 606 E. coli from meat isolated without selective enrichment.
Results
Eleven percent (86/786) of slaughter pigs contained ESC E. coli and a significantly higher prevalence was observed among pigs originating from farms with registered cephalosporin consumption in slaughter pigs (P = 0.034). Among ESC E. coli from pigs, 66% contained bla
CTX-M-1. From meat, a high prevalence of ESC E. coli was found in imported broiler meat (36%) compared with 0.7%-3.3% in other meat types. ESC E. coli from imported broiler meat (n = 69) contained bla
CMY-2 (48%), bla
CTX-M-1 (25%) and bla
SHV-12 (16%). Without selective enrichment, no ESC E. coli from pigs and only 4.1% from imported broiler meat were found.
Conclusions
The usage of cephalosporins for slaughter pigs may increase the prevalence of ESC E. coli in slaughter pigs. Meat may be a source of ESCs in humans, especially imported broiler meat. Selective enrichment should be considered as a supplementary surveillance method. |
doi_str_mv | 10.1093/jac/dkr507 |
format | Article |
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To investigate the prevalence of extended-spectrum cephalosporinase (ESC)-producing Escherichia coli in pigs at slaughter and retail meat, and possible associations with the consumption of third- and fourth-generation cephalosporins.
Methods
During 2009, faecal samples from Danish pigs (n = 786) were collected at slaughter, and 866 meat samples [Danish: pork (153), broiler meat (121) and beef (142); and imported: pork (173), broiler meat (193) and beef (84)] were randomly collected in retail stores and outlets. E. coli was isolated after enrichment in MacConkey broth with ceftriaxone (1 mg/L). ESC genotypes were detected using PCR, microtube array and sequencing. The MIC of cefotaxime was determined for 150 E. coli from the pigs and 606 E. coli from meat isolated without selective enrichment.
Results
Eleven percent (86/786) of slaughter pigs contained ESC E. coli and a significantly higher prevalence was observed among pigs originating from farms with registered cephalosporin consumption in slaughter pigs (P = 0.034). Among ESC E. coli from pigs, 66% contained bla
CTX-M-1. From meat, a high prevalence of ESC E. coli was found in imported broiler meat (36%) compared with 0.7%-3.3% in other meat types. ESC E. coli from imported broiler meat (n = 69) contained bla
CMY-2 (48%), bla
CTX-M-1 (25%) and bla
SHV-12 (16%). Without selective enrichment, no ESC E. coli from pigs and only 4.1% from imported broiler meat were found.
Conclusions
The usage of cephalosporins for slaughter pigs may increase the prevalence of ESC E. coli in slaughter pigs. Meat may be a source of ESCs in humans, especially imported broiler meat. Selective enrichment should be considered as a supplementary surveillance method.</description><identifier>ISSN: 0305-7453</identifier><identifier>EISSN: 1460-2091</identifier><identifier>DOI: 10.1093/jac/dkr507</identifier><identifier>PMID: 22207594</identifier><identifier>CODEN: JACHDX</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject><![CDATA[Animals ; Anti-Bacterial Agents - administration & dosage ; Antibiotics ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antimicrobial agents ; Bacteriological Techniques - methods ; Beef ; Biological and medical sciences ; Cattle ; Cefotaxime ; Ceftriaxone ; Cephalosporinase ; Cephalosporinase - genetics ; Cephalosporinase - secretion ; Cephalosporins ; Cephalosporins - administration & dosage ; Chickens ; Culture Media - chemistry ; Denmark ; DNA, Bacterial - chemistry ; DNA, Bacterial - genetics ; Drug Utilization - statistics & numerical data ; E coli ; Escherichia coli ; Escherichia coli - enzymology ; Escherichia coli - growth & development ; Escherichia coli - isolation & purification ; Escherichia coli Infections - epidemiology ; Escherichia coli Infections - microbiology ; Escherichia coli Infections - veterinary ; Farms ; Feces - microbiology ; Genotype ; Genotype & phenotype ; Genotypes ; Meat ; Meat - microbiology ; Medical sciences ; Minimum inhibitory concentration ; Pharmacology. Drug treatments ; Polymerase Chain Reaction ; Pork ; Prevalence ; Sequence Analysis, DNA ; Slaughter ; Swine]]></subject><ispartof>Journal of antimicrobial chemotherapy, 2012-03, Vol.67 (3), p.582-588</ispartof><rights>The Author 2011. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com 2011</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Oxford Publishing Limited(England) Mar 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-e6caca72da54d8598b1d91721066d628202e8e878fe3293c9707ef42ff6554f33</citedby><cites>FETCH-LOGICAL-c441t-e6caca72da54d8598b1d91721066d628202e8e878fe3293c9707ef42ff6554f33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1584,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25617497$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22207594$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Agersø, Yvonne</creatorcontrib><creatorcontrib>Aarestrup, Frank M.</creatorcontrib><creatorcontrib>Pedersen, Karl</creatorcontrib><creatorcontrib>Seyfarth, Anne Mette</creatorcontrib><creatorcontrib>Struve, Tina</creatorcontrib><creatorcontrib>Hasman, Henrik</creatorcontrib><title>Prevalence of extended-spectrum cephalosporinase (ESC)-producing Escherichia coli in Danish slaughter pigs and retail meat identified by selective enrichment and association with cephalosporin usage</title><title>Journal of antimicrobial chemotherapy</title><addtitle>J Antimicrob Chemother</addtitle><description>Objectives
To investigate the prevalence of extended-spectrum cephalosporinase (ESC)-producing Escherichia coli in pigs at slaughter and retail meat, and possible associations with the consumption of third- and fourth-generation cephalosporins.
Methods
During 2009, faecal samples from Danish pigs (n = 786) were collected at slaughter, and 866 meat samples [Danish: pork (153), broiler meat (121) and beef (142); and imported: pork (173), broiler meat (193) and beef (84)] were randomly collected in retail stores and outlets. E. coli was isolated after enrichment in MacConkey broth with ceftriaxone (1 mg/L). ESC genotypes were detected using PCR, microtube array and sequencing. The MIC of cefotaxime was determined for 150 E. coli from the pigs and 606 E. coli from meat isolated without selective enrichment.
Results
Eleven percent (86/786) of slaughter pigs contained ESC E. coli and a significantly higher prevalence was observed among pigs originating from farms with registered cephalosporin consumption in slaughter pigs (P = 0.034). Among ESC E. coli from pigs, 66% contained bla
CTX-M-1. From meat, a high prevalence of ESC E. coli was found in imported broiler meat (36%) compared with 0.7%-3.3% in other meat types. ESC E. coli from imported broiler meat (n = 69) contained bla
CMY-2 (48%), bla
CTX-M-1 (25%) and bla
SHV-12 (16%). Without selective enrichment, no ESC E. coli from pigs and only 4.1% from imported broiler meat were found.
Conclusions
The usage of cephalosporins for slaughter pigs may increase the prevalence of ESC E. coli in slaughter pigs. Meat may be a source of ESCs in humans, especially imported broiler meat. Selective enrichment should be considered as a supplementary surveillance method.</description><subject>Animals</subject><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Antibiotics</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antimicrobial agents</subject><subject>Bacteriological Techniques - methods</subject><subject>Beef</subject><subject>Biological and medical sciences</subject><subject>Cattle</subject><subject>Cefotaxime</subject><subject>Ceftriaxone</subject><subject>Cephalosporinase</subject><subject>Cephalosporinase - genetics</subject><subject>Cephalosporinase - secretion</subject><subject>Cephalosporins</subject><subject>Cephalosporins - administration & dosage</subject><subject>Chickens</subject><subject>Culture Media - chemistry</subject><subject>Denmark</subject><subject>DNA, Bacterial - chemistry</subject><subject>DNA, Bacterial - genetics</subject><subject>Drug Utilization - statistics & numerical data</subject><subject>E coli</subject><subject>Escherichia coli</subject><subject>Escherichia coli - enzymology</subject><subject>Escherichia coli - growth & development</subject><subject>Escherichia coli - isolation & purification</subject><subject>Escherichia coli Infections - epidemiology</subject><subject>Escherichia coli Infections - microbiology</subject><subject>Escherichia coli Infections - veterinary</subject><subject>Farms</subject><subject>Feces - microbiology</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Genotypes</subject><subject>Meat</subject><subject>Meat - microbiology</subject><subject>Medical sciences</subject><subject>Minimum inhibitory concentration</subject><subject>Pharmacology. Drug treatments</subject><subject>Polymerase Chain Reaction</subject><subject>Pork</subject><subject>Prevalence</subject><subject>Sequence Analysis, DNA</subject><subject>Slaughter</subject><subject>Swine</subject><issn>0305-7453</issn><issn>1460-2091</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0t2O1CAUB_DGaNxx9cYHMMTE-JHUBQqlXJpx_Eg20US9bs7A6ZSxhQrt6r6gzyXrjG70Qq-44Mf_cOAUxX1GnzOqq7M9mDP7OUqqbhQrJmpacqrZzWJFKypLJWR1UtxJaU8prWXd3C5OOOdUSS1Wxff3ES9gQG-QhI7gtxm9RVumCc0cl5EYnHoYQppCdB4SkiebD-un5RSDXYzzO7JJpsfoTO-AmDA44jx5Cd6lnqQBll0_YyST2yUC3pKIM7iBjAgzcRb97DqHlmwvScIhl3QXSNBfxY158-cRSCkYB7MLnnx1c__nlciSYId3i1sdDAnvHdfT4tOrzcf1m_L83eu36xfnpRGCzSXWBgwobkEK20jdbJnVTHFG69rWvOGUY4ONajqsuK6MVlRhJ3jX1VKKrqpOi8eH3Nz_lwXT3I4uGRwG8BiW1GopaplfWf1fcsZExRud5cO_5D4s0ec2MpK0qSrJM3p2QCaGlCJ27RTdCPGyZbS9moI2T0F7mIKMHxwTl-2I9jf99e0ZPDoCSAaGLoI3Ll07WTMltLp2YZn-VfAH7p7LaQ</recordid><startdate>20120301</startdate><enddate>20120301</enddate><creator>Agersø, Yvonne</creator><creator>Aarestrup, Frank M.</creator><creator>Pedersen, Karl</creator><creator>Seyfarth, Anne Mette</creator><creator>Struve, Tina</creator><creator>Hasman, Henrik</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20120301</creationdate><title>Prevalence of extended-spectrum cephalosporinase (ESC)-producing Escherichia coli in Danish slaughter pigs and retail meat identified by selective enrichment and association with cephalosporin usage</title><author>Agersø, Yvonne ; Aarestrup, Frank M. ; Pedersen, Karl ; Seyfarth, Anne Mette ; Struve, Tina ; Hasman, Henrik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-e6caca72da54d8598b1d91721066d628202e8e878fe3293c9707ef42ff6554f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Antibiotics</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antimicrobial agents</topic><topic>Bacteriological Techniques - methods</topic><topic>Beef</topic><topic>Biological and medical sciences</topic><topic>Cattle</topic><topic>Cefotaxime</topic><topic>Ceftriaxone</topic><topic>Cephalosporinase</topic><topic>Cephalosporinase - genetics</topic><topic>Cephalosporinase - secretion</topic><topic>Cephalosporins</topic><topic>Cephalosporins - administration & dosage</topic><topic>Chickens</topic><topic>Culture Media - chemistry</topic><topic>Denmark</topic><topic>DNA, Bacterial - chemistry</topic><topic>DNA, Bacterial - genetics</topic><topic>Drug Utilization - statistics & numerical data</topic><topic>E coli</topic><topic>Escherichia coli</topic><topic>Escherichia coli - enzymology</topic><topic>Escherichia coli - growth & development</topic><topic>Escherichia coli - isolation & purification</topic><topic>Escherichia coli Infections - epidemiology</topic><topic>Escherichia coli Infections - microbiology</topic><topic>Escherichia coli Infections - veterinary</topic><topic>Farms</topic><topic>Feces - microbiology</topic><topic>Genotype</topic><topic>Genotype & phenotype</topic><topic>Genotypes</topic><topic>Meat</topic><topic>Meat - microbiology</topic><topic>Medical sciences</topic><topic>Minimum inhibitory concentration</topic><topic>Pharmacology. Drug treatments</topic><topic>Polymerase Chain Reaction</topic><topic>Pork</topic><topic>Prevalence</topic><topic>Sequence Analysis, DNA</topic><topic>Slaughter</topic><topic>Swine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Agersø, Yvonne</creatorcontrib><creatorcontrib>Aarestrup, Frank M.</creatorcontrib><creatorcontrib>Pedersen, Karl</creatorcontrib><creatorcontrib>Seyfarth, Anne Mette</creatorcontrib><creatorcontrib>Struve, Tina</creatorcontrib><creatorcontrib>Hasman, Henrik</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antimicrobial chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Agersø, Yvonne</au><au>Aarestrup, Frank M.</au><au>Pedersen, Karl</au><au>Seyfarth, Anne Mette</au><au>Struve, Tina</au><au>Hasman, Henrik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence of extended-spectrum cephalosporinase (ESC)-producing Escherichia coli in Danish slaughter pigs and retail meat identified by selective enrichment and association with cephalosporin usage</atitle><jtitle>Journal of antimicrobial chemotherapy</jtitle><addtitle>J Antimicrob Chemother</addtitle><date>2012-03-01</date><risdate>2012</risdate><volume>67</volume><issue>3</issue><spage>582</spage><epage>588</epage><pages>582-588</pages><issn>0305-7453</issn><eissn>1460-2091</eissn><coden>JACHDX</coden><abstract>Objectives
To investigate the prevalence of extended-spectrum cephalosporinase (ESC)-producing Escherichia coli in pigs at slaughter and retail meat, and possible associations with the consumption of third- and fourth-generation cephalosporins.
Methods
During 2009, faecal samples from Danish pigs (n = 786) were collected at slaughter, and 866 meat samples [Danish: pork (153), broiler meat (121) and beef (142); and imported: pork (173), broiler meat (193) and beef (84)] were randomly collected in retail stores and outlets. E. coli was isolated after enrichment in MacConkey broth with ceftriaxone (1 mg/L). ESC genotypes were detected using PCR, microtube array and sequencing. The MIC of cefotaxime was determined for 150 E. coli from the pigs and 606 E. coli from meat isolated without selective enrichment.
Results
Eleven percent (86/786) of slaughter pigs contained ESC E. coli and a significantly higher prevalence was observed among pigs originating from farms with registered cephalosporin consumption in slaughter pigs (P = 0.034). Among ESC E. coli from pigs, 66% contained bla
CTX-M-1. From meat, a high prevalence of ESC E. coli was found in imported broiler meat (36%) compared with 0.7%-3.3% in other meat types. ESC E. coli from imported broiler meat (n = 69) contained bla
CMY-2 (48%), bla
CTX-M-1 (25%) and bla
SHV-12 (16%). Without selective enrichment, no ESC E. coli from pigs and only 4.1% from imported broiler meat were found.
Conclusions
The usage of cephalosporins for slaughter pigs may increase the prevalence of ESC E. coli in slaughter pigs. Meat may be a source of ESCs in humans, especially imported broiler meat. Selective enrichment should be considered as a supplementary surveillance method.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>22207594</pmid><doi>10.1093/jac/dkr507</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Animals Anti-Bacterial Agents - administration & dosage Antibiotics Antibiotics. Antiinfectious agents. Antiparasitic agents Antimicrobial agents Bacteriological Techniques - methods Beef Biological and medical sciences Cattle Cefotaxime Ceftriaxone Cephalosporinase Cephalosporinase - genetics Cephalosporinase - secretion Cephalosporins Cephalosporins - administration & dosage Chickens Culture Media - chemistry Denmark DNA, Bacterial - chemistry DNA, Bacterial - genetics Drug Utilization - statistics & numerical data E coli Escherichia coli Escherichia coli - enzymology Escherichia coli - growth & development Escherichia coli - isolation & purification Escherichia coli Infections - epidemiology Escherichia coli Infections - microbiology Escherichia coli Infections - veterinary Farms Feces - microbiology Genotype Genotype & phenotype Genotypes Meat Meat - microbiology Medical sciences Minimum inhibitory concentration Pharmacology. Drug treatments Polymerase Chain Reaction Pork Prevalence Sequence Analysis, DNA Slaughter Swine |
title | Prevalence of extended-spectrum cephalosporinase (ESC)-producing Escherichia coli in Danish slaughter pigs and retail meat identified by selective enrichment and association with cephalosporin usage |
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