Anticancer agent ellipticine combined with histone deacetylase inhibitors, valproic acid and trichostatin A, is an effective DNA damage strategy in human neuroblastoma

Valproic acid (VPA) and trichostatin A (TSA) exert antitumor activity as histone deacetylase inhibitors, whereas ellipticine action is based mainly on DNA intercalation, inhibition of topoisomerase II and formation of cytochrome P450 (CYP)- and peroxidase-mediated covalent DNA adducts. This is the f...

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Veröffentlicht in:	Neuro-endocrinology letters 2011, Vol.32 Suppl 1, p.101-116
Hauptverfasser:	Poljakova, Jitka, Hrebackova, Jana, Dvorakova, Marketa, Moserova, Michaela, Eckschlager, Tomas, Hrabeta, Jan, Göttlicherova, Marketa, Kopejtkova, Barbora, Frei, Eva, Kizek, Rene, Stiborova, Marie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Combined Chemotherapy Protocols - pharmacology Antineoplastic Combined Chemotherapy Protocols - therapeutic use Brain Neoplasms - drug therapy Brain Neoplasms - genetics Brain Neoplasms - pathology DNA Damage Dose-Response Relationship, Drug Drug Evaluation, Preclinical Ellipticines - administration & dosage Ellipticines - pharmacology Histone Deacetylase Inhibitors - administration & dosage Histone Deacetylase Inhibitors - pharmacology Humans Hydroxamic Acids - administration & dosage Hydroxamic Acids - pharmacology Microsomes, Liver - drug effects Microsomes, Liver - metabolism Models, Biological Neuroblastoma - drug therapy Neuroblastoma - genetics Neuroblastoma - pathology Rats Treatment Outcome Tumor Cells, Cultured Valproic Acid - administration & dosage Valproic Acid - pharmacology
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