The presence of proprioceptive mechanoreceptors in the remnants of the ruptured ACL as a possible source of re-innervation of the ACL autograft
This study investigated the presence of neural mechanoreceptors in the remnants of the ruptured ACL as a possible source of reinnervation of the ACL autologous graft. The remainder of the torn ACL was selected for further histological investigation from 17 patients during ACL reconstruction 3 months...
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| Veröffentlicht in: | Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA sports traumatology, arthroscopy : official journal of the ESSKA, 2001-11, Vol.9 (6), p.364-368 |
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| container_title | Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA |
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| creator | Georgoulis, A D Pappa, L Moebius, U Malamou-Mitsi, V Pappa, S Papageorgiou, C O Agnantis, N J Soucacos, P N |
| description | This study investigated the presence of neural mechanoreceptors in the remnants of the ruptured ACL as a possible source of reinnervation of the ACL autologous graft. The remainder of the torn ACL was selected for further histological investigation from 17 patients during ACL reconstruction 3 months to 3.5 years after injury. Perioperatively two types of ACL remnant were identified. Fifteen patients had portions of ACL adapted at the PCL. In all of these patients we found mechanoreceptors (I and II). In five patients we found mushroomlike remnants which included either none or small numbers of mechanoreceptors. Free neural ends were found in both patient groups. There was a significant difference between the groups in regard to the mean number of mechanoreceptors I and II per slice. In conclusion, in patients with an ACL remnant adapted to the PCL, mechanoreceptors exist even 3 years after injury. If we accept that restoration of proprioception is the result of reinnervation of the ACL, leaving the ACL remnants as a source, if this is surgically possible without risk of Cyclop's lesion, may be of potential benefit to the patient. |
| doi_str_mv | 10.1007/s001670100240 |
| format | Article |
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The remainder of the torn ACL was selected for further histological investigation from 17 patients during ACL reconstruction 3 months to 3.5 years after injury. Perioperatively two types of ACL remnant were identified. Fifteen patients had portions of ACL adapted at the PCL. In all of these patients we found mechanoreceptors (I and II). In five patients we found mushroomlike remnants which included either none or small numbers of mechanoreceptors. Free neural ends were found in both patient groups. There was a significant difference between the groups in regard to the mean number of mechanoreceptors I and II per slice. In conclusion, in patients with an ACL remnant adapted to the PCL, mechanoreceptors exist even 3 years after injury. If we accept that restoration of proprioception is the result of reinnervation of the ACL, leaving the ACL remnants as a source, if this is surgically possible without risk of Cyclop's lesion, may be of potential benefit to the patient.</description><identifier>ISSN: 0942-2056</identifier><identifier>EISSN: 1433-7347</identifier><identifier>DOI: 10.1007/s001670100240</identifier><identifier>PMID: 11734875</identifier><language>eng</language><publisher>Germany: Springer Nature B.V</publisher><subject>Adolescent ; Adult ; Anterior Cruciate Ligament - innervation ; Anterior Cruciate Ligament - surgery ; Anterior Cruciate Ligament Injuries ; Biopsy ; Feedback ; Female ; Humans ; Injuries ; Knee ; Knee Injuries - pathology ; Knee Injuries - surgery ; Knees ; Ligaments ; Male ; Mechanoreceptors - pathology ; Patients ; Posterior Cruciate Ligament - pathology ; Proprioception ; Proprioception - physiology ; Rupture ; Sports ; Surgery ; Tissue Transplantation - methods ; Transplantation, Autologous - methods</subject><ispartof>Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2001-11, Vol.9 (6), p.364-368</ispartof><rights>Springer-Verlag 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-120a731007d7d36bea02e69ae912f3df0f82f1ee10a84b110172da7f82b54ca93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11734875$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Georgoulis, A D</creatorcontrib><creatorcontrib>Pappa, L</creatorcontrib><creatorcontrib>Moebius, U</creatorcontrib><creatorcontrib>Malamou-Mitsi, V</creatorcontrib><creatorcontrib>Pappa, S</creatorcontrib><creatorcontrib>Papageorgiou, C O</creatorcontrib><creatorcontrib>Agnantis, N J</creatorcontrib><creatorcontrib>Soucacos, P N</creatorcontrib><title>The presence of proprioceptive mechanoreceptors in the remnants of the ruptured ACL as a possible source of re-innervation of the ACL autograft</title><title>Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA</title><addtitle>Knee Surg Sports Traumatol Arthrosc</addtitle><description>This study investigated the presence of neural mechanoreceptors in the remnants of the ruptured ACL as a possible source of reinnervation of the ACL autologous graft. The remainder of the torn ACL was selected for further histological investigation from 17 patients during ACL reconstruction 3 months to 3.5 years after injury. Perioperatively two types of ACL remnant were identified. Fifteen patients had portions of ACL adapted at the PCL. In all of these patients we found mechanoreceptors (I and II). In five patients we found mushroomlike remnants which included either none or small numbers of mechanoreceptors. Free neural ends were found in both patient groups. There was a significant difference between the groups in regard to the mean number of mechanoreceptors I and II per slice. In conclusion, in patients with an ACL remnant adapted to the PCL, mechanoreceptors exist even 3 years after injury. If we accept that restoration of proprioception is the result of reinnervation of the ACL, leaving the ACL remnants as a source, if this is surgically possible without risk of Cyclop's lesion, may be of potential benefit to the patient.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Anterior Cruciate Ligament - innervation</subject><subject>Anterior Cruciate Ligament - surgery</subject><subject>Anterior Cruciate Ligament Injuries</subject><subject>Biopsy</subject><subject>Feedback</subject><subject>Female</subject><subject>Humans</subject><subject>Injuries</subject><subject>Knee</subject><subject>Knee Injuries - pathology</subject><subject>Knee Injuries - surgery</subject><subject>Knees</subject><subject>Ligaments</subject><subject>Male</subject><subject>Mechanoreceptors - pathology</subject><subject>Patients</subject><subject>Posterior Cruciate Ligament - pathology</subject><subject>Proprioception</subject><subject>Proprioception - physiology</subject><subject>Rupture</subject><subject>Sports</subject><subject>Surgery</subject><subject>Tissue Transplantation - methods</subject><subject>Transplantation, Autologous - methods</subject><issn>0942-2056</issn><issn>1433-7347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kT1v2zAQhomiQeO4HbMWRIdmUnv8kCiNgdF8AAa6JLNASadahkWqJBUgvyJ_OefYRZEMmXg8PO97eO8YOxfwQwCYnxFAFAaolho-sIXQSmVGafORLaDSMpOQF6fsLMYtAJW6-sROhSCiNPmCPd1tkE8BI7oWue-p9lMYfItTGh6Qj9hurPMB9w0fIh8cTyQJODrrUtxLXv7zlOaAHb9crbmN3PLJxzg0O-TRz-HgHTAbnMPwYNPg3T_pi2JO_k-wffrMTnq7i_jl-C7Z_dWvu9VNtv59fbu6XGetFjplQoI1ar-AznSqaNCCxKKyWAnZq66HvpS9QBRgS90IAcLIzhrqNrlubaWW7OLgS3n_zhhTPQ6xxd3OOvRzrKtcF5oGFER-f5c0UslSVDmB396AW0ruKEVdSWlK8gKCsgPUBtpPwL6mbY82PNYC6n2e-tVBif96NJ2bEbv_9PGC6hkzY5uR</recordid><startdate>20011101</startdate><enddate>20011101</enddate><creator>Georgoulis, A D</creator><creator>Pappa, L</creator><creator>Moebius, U</creator><creator>Malamou-Mitsi, V</creator><creator>Pappa, S</creator><creator>Papageorgiou, C O</creator><creator>Agnantis, N J</creator><creator>Soucacos, P N</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20011101</creationdate><title>The presence of proprioceptive mechanoreceptors in the remnants of the ruptured ACL as a possible source of re-innervation of the ACL autograft</title><author>Georgoulis, A D ; Pappa, L ; Moebius, U ; Malamou-Mitsi, V ; Pappa, S ; Papageorgiou, C O ; Agnantis, N J ; Soucacos, P N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-120a731007d7d36bea02e69ae912f3df0f82f1ee10a84b110172da7f82b54ca93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Anterior Cruciate Ligament - innervation</topic><topic>Anterior Cruciate Ligament - surgery</topic><topic>Anterior Cruciate Ligament Injuries</topic><topic>Biopsy</topic><topic>Feedback</topic><topic>Female</topic><topic>Humans</topic><topic>Injuries</topic><topic>Knee</topic><topic>Knee Injuries - pathology</topic><topic>Knee Injuries - surgery</topic><topic>Knees</topic><topic>Ligaments</topic><topic>Male</topic><topic>Mechanoreceptors - pathology</topic><topic>Patients</topic><topic>Posterior Cruciate Ligament - pathology</topic><topic>Proprioception</topic><topic>Proprioception - physiology</topic><topic>Rupture</topic><topic>Sports</topic><topic>Surgery</topic><topic>Tissue Transplantation - methods</topic><topic>Transplantation, Autologous - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Georgoulis, A D</creatorcontrib><creatorcontrib>Pappa, L</creatorcontrib><creatorcontrib>Moebius, U</creatorcontrib><creatorcontrib>Malamou-Mitsi, V</creatorcontrib><creatorcontrib>Pappa, S</creatorcontrib><creatorcontrib>Papageorgiou, C O</creatorcontrib><creatorcontrib>Agnantis, N J</creatorcontrib><creatorcontrib>Soucacos, P N</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database (ProQuest)</collection><collection>Physical Education Index</collection><collection>Health & Medicine (ProQuest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Georgoulis, A D</au><au>Pappa, L</au><au>Moebius, U</au><au>Malamou-Mitsi, V</au><au>Pappa, S</au><au>Papageorgiou, C O</au><au>Agnantis, N J</au><au>Soucacos, P N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The presence of proprioceptive mechanoreceptors in the remnants of the ruptured ACL as a possible source of re-innervation of the ACL autograft</atitle><jtitle>Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA</jtitle><addtitle>Knee Surg Sports Traumatol Arthrosc</addtitle><date>2001-11-01</date><risdate>2001</risdate><volume>9</volume><issue>6</issue><spage>364</spage><epage>368</epage><pages>364-368</pages><issn>0942-2056</issn><eissn>1433-7347</eissn><abstract>This study investigated the presence of neural mechanoreceptors in the remnants of the ruptured ACL as a possible source of reinnervation of the ACL autologous graft. The remainder of the torn ACL was selected for further histological investigation from 17 patients during ACL reconstruction 3 months to 3.5 years after injury. Perioperatively two types of ACL remnant were identified. Fifteen patients had portions of ACL adapted at the PCL. In all of these patients we found mechanoreceptors (I and II). In five patients we found mushroomlike remnants which included either none or small numbers of mechanoreceptors. Free neural ends were found in both patient groups. There was a significant difference between the groups in regard to the mean number of mechanoreceptors I and II per slice. In conclusion, in patients with an ACL remnant adapted to the PCL, mechanoreceptors exist even 3 years after injury. If we accept that restoration of proprioception is the result of reinnervation of the ACL, leaving the ACL remnants as a source, if this is surgically possible without risk of Cyclop's lesion, may be of potential benefit to the patient.</abstract><cop>Germany</cop><pub>Springer Nature B.V</pub><pmid>11734875</pmid><doi>10.1007/s001670100240</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0942-2056 |
| ispartof | Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2001-11, Vol.9 (6), p.364-368 |
| issn | 0942-2056 1433-7347 |
| language | eng |
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| source | Wiley-Blackwell Journals; MEDLINE; SpringerLink (Online service) |
| subjects | Adolescent Adult Anterior Cruciate Ligament - innervation Anterior Cruciate Ligament - surgery Anterior Cruciate Ligament Injuries Biopsy Feedback Female Humans Injuries Knee Knee Injuries - pathology Knee Injuries - surgery Knees Ligaments Male Mechanoreceptors - pathology Patients Posterior Cruciate Ligament - pathology Proprioception Proprioception - physiology Rupture Sports Surgery Tissue Transplantation - methods Transplantation, Autologous - methods |
| title | The presence of proprioceptive mechanoreceptors in the remnants of the ruptured ACL as a possible source of re-innervation of the ACL autograft |
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