An implantable Fabry-Pérot pressure sensor fabricated on left ventricular assist device for heart failure
Continuous flow left ventricular assist devices (LVADs) are commonly used as bridge-to-transplantation or destination therapy for heart failure patients. However, non-optimal pumping speeds can reduce the efficacy of circulatory support or cause dangerous ventricular arrhythmias. Optimal flow contro...
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| Veröffentlicht in: | Biomedical microdevices 2012-02, Vol.14 (1), p.235-245 |
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| creator | Zhou, Ming-Da Yang, Chuan Liu, Zhiwen Cysyk, Joshua P. Zheng, Si-Yang |
| description | Continuous flow left ventricular assist devices (LVADs) are commonly used as bridge-to-transplantation or destination therapy for heart failure patients. However, non-optimal pumping speeds can reduce the efficacy of circulatory support or cause dangerous ventricular arrhythmias. Optimal flow control for continuous flow LVADs has not been defined and calls for an implantable pressure sensor integrated with the LVAD for real-time feedback control of pump speed based on ventricular pressure. A MEMS pressure sensor prototype is designed, fabricated and seamlessly integrated with LVAD to enable real-time control, optimize its performance and reduce its risks. The pressure sensing mechanism is based on Fabry-Pérot interferometer principle. A biocompatible parylene diaphragm with a silicon mirror at the center is fabricated directly on the inlet shell of the LVAD to sense pressure changes. The sensitivity, range and response time of the pressure sensor are measured and validated to meet the requirements of LVAD pressure sensing. |
| doi_str_mv | 10.1007/s10544-011-9601-z |
| format | Article |
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However, non-optimal pumping speeds can reduce the efficacy of circulatory support or cause dangerous ventricular arrhythmias. Optimal flow control for continuous flow LVADs has not been defined and calls for an implantable pressure sensor integrated with the LVAD for real-time feedback control of pump speed based on ventricular pressure. A MEMS pressure sensor prototype is designed, fabricated and seamlessly integrated with LVAD to enable real-time control, optimize its performance and reduce its risks. The pressure sensing mechanism is based on Fabry-Pérot interferometer principle. A biocompatible parylene diaphragm with a silicon mirror at the center is fabricated directly on the inlet shell of the LVAD to sense pressure changes. The sensitivity, range and response time of the pressure sensor are measured and validated to meet the requirements of LVAD pressure sensing.</description><identifier>ISSN: 1387-2176</identifier><identifier>EISSN: 1572-8781</identifier><identifier>DOI: 10.1007/s10544-011-9601-z</identifier><identifier>PMID: 21997499</identifier><identifier>CODEN: BMICFC</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Biological and Medical Physics ; Biomedical Engineering and Bioengineering ; Biophysics ; Engineering ; Engineering Fluid Dynamics ; Heart Failure - therapy ; Heart-Assist Devices ; Humans ; Nanotechnology ; Pressure</subject><ispartof>Biomedical microdevices, 2012-02, Vol.14 (1), p.235-245</ispartof><rights>Springer Science+Business Media, LLC 2011</rights><rights>Springer Science+Business Media, LLC 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-1306b3886b3b6dcaf54a8b514ddd263955af6ed2bdbe5f60f895def9724614053</citedby><cites>FETCH-LOGICAL-c402t-1306b3886b3b6dcaf54a8b514ddd263955af6ed2bdbe5f60f895def9724614053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10544-011-9601-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10544-011-9601-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21997499$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhou, Ming-Da</creatorcontrib><creatorcontrib>Yang, Chuan</creatorcontrib><creatorcontrib>Liu, Zhiwen</creatorcontrib><creatorcontrib>Cysyk, Joshua P.</creatorcontrib><creatorcontrib>Zheng, Si-Yang</creatorcontrib><title>An implantable Fabry-Pérot pressure sensor fabricated on left ventricular assist device for heart failure</title><title>Biomedical microdevices</title><addtitle>Biomed Microdevices</addtitle><addtitle>Biomed Microdevices</addtitle><description>Continuous flow left ventricular assist devices (LVADs) are commonly used as bridge-to-transplantation or destination therapy for heart failure patients. However, non-optimal pumping speeds can reduce the efficacy of circulatory support or cause dangerous ventricular arrhythmias. Optimal flow control for continuous flow LVADs has not been defined and calls for an implantable pressure sensor integrated with the LVAD for real-time feedback control of pump speed based on ventricular pressure. A MEMS pressure sensor prototype is designed, fabricated and seamlessly integrated with LVAD to enable real-time control, optimize its performance and reduce its risks. The pressure sensing mechanism is based on Fabry-Pérot interferometer principle. A biocompatible parylene diaphragm with a silicon mirror at the center is fabricated directly on the inlet shell of the LVAD to sense pressure changes. The sensitivity, range and response time of the pressure sensor are measured and validated to meet the requirements of LVAD pressure sensing.</description><subject>Biological and Medical Physics</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biophysics</subject><subject>Engineering</subject><subject>Engineering Fluid Dynamics</subject><subject>Heart Failure - therapy</subject><subject>Heart-Assist Devices</subject><subject>Humans</subject><subject>Nanotechnology</subject><subject>Pressure</subject><issn>1387-2176</issn><issn>1572-8781</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkdFqFTEQhoMotlYfwBsJ3ngVm8km2c1lKa0KBXuh1yG7mege9uweM9lC-0Y-hy_WHE5VEITeTIbM9__D8DP2GuR7kLI9JZBGayEBhLMSxN0TdgymVaJrO3ha-6ZrhYLWHrEXRBspwVlrn7MjBc612rljtjmb-bjdTWEuoZ-QX4Y-34rrXz_zUvguI9GakRPOtGSe6nAcQsHIl5lPmAq_wbnUv3UKmQeikQqPeDMOyFMVfMeQS5WNU3V5yZ6lMBG-enhP2NfLiy_nH8XV5w-fzs-uxKClKgIaafum62rpbRxCMjp0vQEdY1S2ccaEZDGqPvZokpWpcyZicq3SFrQ0zQl7d_Dd5eXHilT8dqQBp3ojLit5Z7TVIPUjSKWdBeNsJd_-Q26WNc_1jAo1rVKN2dvBARryQpQx-V0etyHfepB-H5g_BOZrYH4fmL-rmjcPxmu_xfhH8TuhCqgDQHU0f8P8d_P_Xe8BkVOiog</recordid><startdate>20120201</startdate><enddate>20120201</enddate><creator>Zhou, Ming-Da</creator><creator>Yang, Chuan</creator><creator>Liu, Zhiwen</creator><creator>Cysyk, Joshua P.</creator><creator>Zheng, Si-Yang</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7SP</scope><scope>7TB</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>L6V</scope><scope>L7M</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20120201</creationdate><title>An implantable Fabry-Pérot pressure sensor fabricated on left ventricular assist device for heart failure</title><author>Zhou, Ming-Da ; Yang, Chuan ; Liu, Zhiwen ; Cysyk, Joshua P. ; Zheng, Si-Yang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-1306b3886b3b6dcaf54a8b514ddd263955af6ed2bdbe5f60f895def9724614053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Biological and Medical Physics</topic><topic>Biomedical Engineering and Bioengineering</topic><topic>Biophysics</topic><topic>Engineering</topic><topic>Engineering Fluid Dynamics</topic><topic>Heart Failure - 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Academic</collection><jtitle>Biomedical microdevices</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Ming-Da</au><au>Yang, Chuan</au><au>Liu, Zhiwen</au><au>Cysyk, Joshua P.</au><au>Zheng, Si-Yang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An implantable Fabry-Pérot pressure sensor fabricated on left ventricular assist device for heart failure</atitle><jtitle>Biomedical microdevices</jtitle><stitle>Biomed Microdevices</stitle><addtitle>Biomed Microdevices</addtitle><date>2012-02-01</date><risdate>2012</risdate><volume>14</volume><issue>1</issue><spage>235</spage><epage>245</epage><pages>235-245</pages><issn>1387-2176</issn><eissn>1572-8781</eissn><coden>BMICFC</coden><abstract>Continuous flow left ventricular assist devices (LVADs) are commonly used as bridge-to-transplantation or destination therapy for heart failure patients. However, non-optimal pumping speeds can reduce the efficacy of circulatory support or cause dangerous ventricular arrhythmias. Optimal flow control for continuous flow LVADs has not been defined and calls for an implantable pressure sensor integrated with the LVAD for real-time feedback control of pump speed based on ventricular pressure. A MEMS pressure sensor prototype is designed, fabricated and seamlessly integrated with LVAD to enable real-time control, optimize its performance and reduce its risks. The pressure sensing mechanism is based on Fabry-Pérot interferometer principle. A biocompatible parylene diaphragm with a silicon mirror at the center is fabricated directly on the inlet shell of the LVAD to sense pressure changes. The sensitivity, range and response time of the pressure sensor are measured and validated to meet the requirements of LVAD pressure sensing.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>21997499</pmid><doi>10.1007/s10544-011-9601-z</doi><tpages>11</tpages></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Biological and Medical Physics Biomedical Engineering and Bioengineering Biophysics Engineering Engineering Fluid Dynamics Heart Failure - therapy Heart-Assist Devices Humans Nanotechnology Pressure |
| title | An implantable Fabry-Pérot pressure sensor fabricated on left ventricular assist device for heart failure |
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