Increased oxidative/nitrosative stress markers measured non- invasively in patients with high 2,3,7,8-tetrachloro-dibenzo-p-dioxin plasma level
2,3,7,8-tetrachloro-dibenzo-p-dioxin (TCDD) is a highly toxic persistent environmental contaminant, classified as a human carcinogen affecting any target organ. The mechanism of carcinogenesis by TCDD is unclear as TCDD shows a lack of direct genotoxicity. Experimental studies also support the role...
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| creator | Pelclova, Daniela Navratil, Tomas Fenclova, Zdenka Vlckova, Stepanka Kupka, Karel Urban, Pavel Ridzon, Petr Zikan, Vit Landova, Ludmila Syslova, Kamila Kuzma, Marek Kacer, Petr |
| description | 2,3,7,8-tetrachloro-dibenzo-p-dioxin (TCDD) is a highly toxic persistent environmental contaminant, classified as a human carcinogen affecting any target organ. The mechanism of carcinogenesis by TCDD is unclear as TCDD shows a lack of direct genotoxicity. Experimental studies also support the role of oxidative stress in TCDD neurotoxicity and vascular dysfunction. The aim was to investigate markers of oxidative/nitrosative stress and inflammation using non-invasive methods in subjects who got ill due to severe occupational exposure to TCDD in the years 1965-1968.
In 11 TCDD-exposed patients, and 16 controls, the analysis of following oxidative products of lipids, proteins and nucleic acids in plasma, urine and exhaled breath condensate (EBC) was performed: 8-iso-prostaglandin F2α (8-isoprostane), 4-hydroxy-trans-2-nonenale (HNE), malondialdehyde (MDA), o-tyrosine (o-Tyr), 8-hydroxyguanosine (8-OHG), 8-hydroxy-2´-deoxy-guanosine (8-OHdG), 5-hydroxymethyluracil (5-OHMeU). In addition, nitric-oxide-tyrosine (NO-Tyr) and leukotriene (LT) B4, C4, D4, and E4 were detected by liquid chromatography-mass spectrometry/mass spectrometry (LC-ESI-MS/MS). TCDD was measured by HRGC/HRMS, body lipid content by densitometry. Single-photon emission spectrometry (SPECT) of the brain was performed and compared with the findings of the patients in 2008.
Mean TCDD plasma level in 2010 was 175 ± 162 pg/g lipids (population level about 2 pg/g), total TCDD content in the body 5.16 ± 4.62 mg. Reduction of cerebral blood flow in SPECT progressed in 8 patients, finding was stable in 2 subjects, and improvement occurred in 1 patient. In the EBC, 10 from 12 markers (all except LT D4 and LT E4), were significantly increased in the patients (p |
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In 11 TCDD-exposed patients, and 16 controls, the analysis of following oxidative products of lipids, proteins and nucleic acids in plasma, urine and exhaled breath condensate (EBC) was performed: 8-iso-prostaglandin F2α (8-isoprostane), 4-hydroxy-trans-2-nonenale (HNE), malondialdehyde (MDA), o-tyrosine (o-Tyr), 8-hydroxyguanosine (8-OHG), 8-hydroxy-2´-deoxy-guanosine (8-OHdG), 5-hydroxymethyluracil (5-OHMeU). In addition, nitric-oxide-tyrosine (NO-Tyr) and leukotriene (LT) B4, C4, D4, and E4 were detected by liquid chromatography-mass spectrometry/mass spectrometry (LC-ESI-MS/MS). TCDD was measured by HRGC/HRMS, body lipid content by densitometry. Single-photon emission spectrometry (SPECT) of the brain was performed and compared with the findings of the patients in 2008.
Mean TCDD plasma level in 2010 was 175 ± 162 pg/g lipids (population level about 2 pg/g), total TCDD content in the body 5.16 ± 4.62 mg. Reduction of cerebral blood flow in SPECT progressed in 8 patients, finding was stable in 2 subjects, and improvement occurred in 1 patient. In the EBC, 10 from 12 markers (all except LT D4 and LT E4), were significantly increased in the patients (p<0.05). In the urine, 7 markers were significantly higher than in the controls (p<0.05): 8-isoprostane, MDA, HNE, LT C4, LT E4, o-Tyr and NO-Tyr. In plasma, only NO-Tyr and 8-OHG were elevated (p<0.05).
NO-Tyr was increased in all matrices in dioxin-exposed patients. EBC is not limited to lung disorders as the markers of oxidative stress and inflammation were elevated in EBC of patients with normal lung functions. TCDD-induced oxidative stress and inflammation markers can be detected non-invasively in the EBC and urine in the follow-up of the highly-exposed patients. Their prognostic value, however, needs to be elucidated.</description><identifier>ISSN: 0172-780X</identifier><identifier>PMID: 22167218</identifier><language>eng</language><publisher>Sweden</publisher><subject>Aged ; Biomarkers - analysis ; Biomarkers - blood ; Biomarkers - urine ; Blood Chemical Analysis - methods ; Case-Control Studies ; Chemical Industry ; Female ; Herbicides - analysis ; Herbicides - blood ; Humans ; Male ; Middle Aged ; Occupational Exposure - analysis ; Osmolar Concentration ; Oxidative Stress - physiology ; Polychlorinated Dibenzodioxins - analogs & derivatives ; Polychlorinated Dibenzodioxins - analysis ; Polychlorinated Dibenzodioxins - blood ; Reactive Nitrogen Species - analysis ; Reactive Nitrogen Species - blood ; Reactive Nitrogen Species - metabolism ; Reactive Nitrogen Species - urine ; Reactive Oxygen Species - analysis ; Reactive Oxygen Species - blood ; Reactive Oxygen Species - metabolism ; Reactive Oxygen Species - urine ; Up-Regulation ; Urinalysis - methods</subject><ispartof>Neuro-endocrinology letters, 2011, Vol.32 Suppl 1, p.71-76</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22167218$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pelclova, Daniela</creatorcontrib><creatorcontrib>Navratil, Tomas</creatorcontrib><creatorcontrib>Fenclova, Zdenka</creatorcontrib><creatorcontrib>Vlckova, Stepanka</creatorcontrib><creatorcontrib>Kupka, Karel</creatorcontrib><creatorcontrib>Urban, Pavel</creatorcontrib><creatorcontrib>Ridzon, Petr</creatorcontrib><creatorcontrib>Zikan, Vit</creatorcontrib><creatorcontrib>Landova, Ludmila</creatorcontrib><creatorcontrib>Syslova, Kamila</creatorcontrib><creatorcontrib>Kuzma, Marek</creatorcontrib><creatorcontrib>Kacer, Petr</creatorcontrib><title>Increased oxidative/nitrosative stress markers measured non- invasively in patients with high 2,3,7,8-tetrachloro-dibenzo-p-dioxin plasma level</title><title>Neuro-endocrinology letters</title><addtitle>Neuro Endocrinol Lett</addtitle><description>2,3,7,8-tetrachloro-dibenzo-p-dioxin (TCDD) is a highly toxic persistent environmental contaminant, classified as a human carcinogen affecting any target organ. The mechanism of carcinogenesis by TCDD is unclear as TCDD shows a lack of direct genotoxicity. Experimental studies also support the role of oxidative stress in TCDD neurotoxicity and vascular dysfunction. The aim was to investigate markers of oxidative/nitrosative stress and inflammation using non-invasive methods in subjects who got ill due to severe occupational exposure to TCDD in the years 1965-1968.
In 11 TCDD-exposed patients, and 16 controls, the analysis of following oxidative products of lipids, proteins and nucleic acids in plasma, urine and exhaled breath condensate (EBC) was performed: 8-iso-prostaglandin F2α (8-isoprostane), 4-hydroxy-trans-2-nonenale (HNE), malondialdehyde (MDA), o-tyrosine (o-Tyr), 8-hydroxyguanosine (8-OHG), 8-hydroxy-2´-deoxy-guanosine (8-OHdG), 5-hydroxymethyluracil (5-OHMeU). In addition, nitric-oxide-tyrosine (NO-Tyr) and leukotriene (LT) B4, C4, D4, and E4 were detected by liquid chromatography-mass spectrometry/mass spectrometry (LC-ESI-MS/MS). TCDD was measured by HRGC/HRMS, body lipid content by densitometry. Single-photon emission spectrometry (SPECT) of the brain was performed and compared with the findings of the patients in 2008.
Mean TCDD plasma level in 2010 was 175 ± 162 pg/g lipids (population level about 2 pg/g), total TCDD content in the body 5.16 ± 4.62 mg. Reduction of cerebral blood flow in SPECT progressed in 8 patients, finding was stable in 2 subjects, and improvement occurred in 1 patient. In the EBC, 10 from 12 markers (all except LT D4 and LT E4), were significantly increased in the patients (p<0.05). In the urine, 7 markers were significantly higher than in the controls (p<0.05): 8-isoprostane, MDA, HNE, LT C4, LT E4, o-Tyr and NO-Tyr. In plasma, only NO-Tyr and 8-OHG were elevated (p<0.05).
NO-Tyr was increased in all matrices in dioxin-exposed patients. EBC is not limited to lung disorders as the markers of oxidative stress and inflammation were elevated in EBC of patients with normal lung functions. TCDD-induced oxidative stress and inflammation markers can be detected non-invasively in the EBC and urine in the follow-up of the highly-exposed patients. Their prognostic value, however, needs to be elucidated.</description><subject>Aged</subject><subject>Biomarkers - analysis</subject><subject>Biomarkers - blood</subject><subject>Biomarkers - urine</subject><subject>Blood Chemical Analysis - methods</subject><subject>Case-Control Studies</subject><subject>Chemical Industry</subject><subject>Female</subject><subject>Herbicides - analysis</subject><subject>Herbicides - blood</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Occupational Exposure - analysis</subject><subject>Osmolar Concentration</subject><subject>Oxidative Stress - physiology</subject><subject>Polychlorinated Dibenzodioxins - analogs & derivatives</subject><subject>Polychlorinated Dibenzodioxins - analysis</subject><subject>Polychlorinated Dibenzodioxins - blood</subject><subject>Reactive Nitrogen Species - analysis</subject><subject>Reactive Nitrogen Species - blood</subject><subject>Reactive Nitrogen Species - metabolism</subject><subject>Reactive Nitrogen Species - urine</subject><subject>Reactive Oxygen Species - analysis</subject><subject>Reactive Oxygen Species - blood</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Reactive Oxygen Species - urine</subject><subject>Up-Regulation</subject><subject>Urinalysis - methods</subject><issn>0172-780X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkL1OwzAcxDOAaCm8AvLGUgt_xIkzooovqRILSGyRXf9DDEkcbKdQXoJXxoIyM90Nv7uT7iCbE1oyXEryNMuOQ3ghhFWC8aNsxhgtSkblPPu6GzYeVACD3Ic1KtotXAw2ehd-PArRQwioV_4VfNLETj7RgxswssNWhUR1u2TRmBIwxIDebWxRa59bxJZ8WS4ljhC92rSd8w4bq2H4dHhMLm2mXKdCr1AHqegkO2xUF-B0r4vs8frqYXWL1_c3d6vLNR5ZziI2XNKGS9CN0VpQynNgkpuCMs1MrjkIowvCqJCVgEqyotGlEE3TEGBVXmq-yM5_e0fv3iYIse5t2EDXqQHcFOpK5EVOpKD_k2m4qDiRiTzbk5PuwdSjt-m2Xf33Nv8GysJ9EQ</recordid><startdate>2011</startdate><enddate>2011</enddate><creator>Pelclova, Daniela</creator><creator>Navratil, Tomas</creator><creator>Fenclova, Zdenka</creator><creator>Vlckova, Stepanka</creator><creator>Kupka, Karel</creator><creator>Urban, Pavel</creator><creator>Ridzon, Petr</creator><creator>Zikan, Vit</creator><creator>Landova, Ludmila</creator><creator>Syslova, Kamila</creator><creator>Kuzma, Marek</creator><creator>Kacer, Petr</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>7T2</scope><scope>7TK</scope><scope>7U2</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>2011</creationdate><title>Increased oxidative/nitrosative stress markers measured non- invasively in patients with high 2,3,7,8-tetrachloro-dibenzo-p-dioxin plasma level</title><author>Pelclova, Daniela ; Navratil, Tomas ; Fenclova, Zdenka ; Vlckova, Stepanka ; Kupka, Karel ; Urban, Pavel ; Ridzon, Petr ; Zikan, Vit ; Landova, Ludmila ; Syslova, Kamila ; Kuzma, Marek ; Kacer, Petr</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p242t-d381f38ebfdbb51134e283d612b2d4b3e5db60215895e9826fb755fff0e2947b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aged</topic><topic>Biomarkers - analysis</topic><topic>Biomarkers - blood</topic><topic>Biomarkers - urine</topic><topic>Blood Chemical Analysis - methods</topic><topic>Case-Control Studies</topic><topic>Chemical Industry</topic><topic>Female</topic><topic>Herbicides - analysis</topic><topic>Herbicides - blood</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Occupational Exposure - analysis</topic><topic>Osmolar Concentration</topic><topic>Oxidative Stress - physiology</topic><topic>Polychlorinated Dibenzodioxins - analogs & derivatives</topic><topic>Polychlorinated Dibenzodioxins - analysis</topic><topic>Polychlorinated Dibenzodioxins - blood</topic><topic>Reactive Nitrogen Species - analysis</topic><topic>Reactive Nitrogen Species - blood</topic><topic>Reactive Nitrogen Species - metabolism</topic><topic>Reactive Nitrogen Species - urine</topic><topic>Reactive Oxygen Species - analysis</topic><topic>Reactive Oxygen Species - blood</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Reactive Oxygen Species - urine</topic><topic>Up-Regulation</topic><topic>Urinalysis - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pelclova, Daniela</creatorcontrib><creatorcontrib>Navratil, Tomas</creatorcontrib><creatorcontrib>Fenclova, Zdenka</creatorcontrib><creatorcontrib>Vlckova, Stepanka</creatorcontrib><creatorcontrib>Kupka, Karel</creatorcontrib><creatorcontrib>Urban, Pavel</creatorcontrib><creatorcontrib>Ridzon, Petr</creatorcontrib><creatorcontrib>Zikan, Vit</creatorcontrib><creatorcontrib>Landova, Ludmila</creatorcontrib><creatorcontrib>Syslova, Kamila</creatorcontrib><creatorcontrib>Kuzma, Marek</creatorcontrib><creatorcontrib>Kacer, Petr</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Neuro-endocrinology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pelclova, Daniela</au><au>Navratil, Tomas</au><au>Fenclova, Zdenka</au><au>Vlckova, Stepanka</au><au>Kupka, Karel</au><au>Urban, Pavel</au><au>Ridzon, Petr</au><au>Zikan, Vit</au><au>Landova, Ludmila</au><au>Syslova, Kamila</au><au>Kuzma, Marek</au><au>Kacer, Petr</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased oxidative/nitrosative stress markers measured non- invasively in patients with high 2,3,7,8-tetrachloro-dibenzo-p-dioxin plasma level</atitle><jtitle>Neuro-endocrinology letters</jtitle><addtitle>Neuro Endocrinol Lett</addtitle><date>2011</date><risdate>2011</risdate><volume>32 Suppl 1</volume><spage>71</spage><epage>76</epage><pages>71-76</pages><issn>0172-780X</issn><abstract>2,3,7,8-tetrachloro-dibenzo-p-dioxin (TCDD) is a highly toxic persistent environmental contaminant, classified as a human carcinogen affecting any target organ. The mechanism of carcinogenesis by TCDD is unclear as TCDD shows a lack of direct genotoxicity. Experimental studies also support the role of oxidative stress in TCDD neurotoxicity and vascular dysfunction. The aim was to investigate markers of oxidative/nitrosative stress and inflammation using non-invasive methods in subjects who got ill due to severe occupational exposure to TCDD in the years 1965-1968.
In 11 TCDD-exposed patients, and 16 controls, the analysis of following oxidative products of lipids, proteins and nucleic acids in plasma, urine and exhaled breath condensate (EBC) was performed: 8-iso-prostaglandin F2α (8-isoprostane), 4-hydroxy-trans-2-nonenale (HNE), malondialdehyde (MDA), o-tyrosine (o-Tyr), 8-hydroxyguanosine (8-OHG), 8-hydroxy-2´-deoxy-guanosine (8-OHdG), 5-hydroxymethyluracil (5-OHMeU). In addition, nitric-oxide-tyrosine (NO-Tyr) and leukotriene (LT) B4, C4, D4, and E4 were detected by liquid chromatography-mass spectrometry/mass spectrometry (LC-ESI-MS/MS). TCDD was measured by HRGC/HRMS, body lipid content by densitometry. Single-photon emission spectrometry (SPECT) of the brain was performed and compared with the findings of the patients in 2008.
Mean TCDD plasma level in 2010 was 175 ± 162 pg/g lipids (population level about 2 pg/g), total TCDD content in the body 5.16 ± 4.62 mg. Reduction of cerebral blood flow in SPECT progressed in 8 patients, finding was stable in 2 subjects, and improvement occurred in 1 patient. In the EBC, 10 from 12 markers (all except LT D4 and LT E4), were significantly increased in the patients (p<0.05). In the urine, 7 markers were significantly higher than in the controls (p<0.05): 8-isoprostane, MDA, HNE, LT C4, LT E4, o-Tyr and NO-Tyr. In plasma, only NO-Tyr and 8-OHG were elevated (p<0.05).
NO-Tyr was increased in all matrices in dioxin-exposed patients. EBC is not limited to lung disorders as the markers of oxidative stress and inflammation were elevated in EBC of patients with normal lung functions. TCDD-induced oxidative stress and inflammation markers can be detected non-invasively in the EBC and urine in the follow-up of the highly-exposed patients. Their prognostic value, however, needs to be elucidated.</abstract><cop>Sweden</cop><pmid>22167218</pmid><tpages>6</tpages></addata></record> |
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| ispartof | Neuro-endocrinology letters, 2011, Vol.32 Suppl 1, p.71-76 |
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| subjects | Aged Biomarkers - analysis Biomarkers - blood Biomarkers - urine Blood Chemical Analysis - methods Case-Control Studies Chemical Industry Female Herbicides - analysis Herbicides - blood Humans Male Middle Aged Occupational Exposure - analysis Osmolar Concentration Oxidative Stress - physiology Polychlorinated Dibenzodioxins - analogs & derivatives Polychlorinated Dibenzodioxins - analysis Polychlorinated Dibenzodioxins - blood Reactive Nitrogen Species - analysis Reactive Nitrogen Species - blood Reactive Nitrogen Species - metabolism Reactive Nitrogen Species - urine Reactive Oxygen Species - analysis Reactive Oxygen Species - blood Reactive Oxygen Species - metabolism Reactive Oxygen Species - urine Up-Regulation Urinalysis - methods |
| title | Increased oxidative/nitrosative stress markers measured non- invasively in patients with high 2,3,7,8-tetrachloro-dibenzo-p-dioxin plasma level |
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