High APOE epsilon 4 allele frequencies associated with Alzheimer disease in a Tunisian population
The goal of the study was to examine the Apolipoprotein E ( APOE ) genotypes in a Tunisian sample of patients with Alzheimer disease (AD) and normal controls, and to compare the results with the findings from the literature. A hospital-based case–control study of two groups (58 patients with AD, 71...
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| Veröffentlicht in: | Neurological sciences 2012-02, Vol.33 (1), p.33-37 |
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| creator | Rassas, Afef Achouri Mrabet Khiari, Hela Hadj Fredj, Sondes Sahnoun, Safa Batti, Hend Zakraoui, Nouria Oudiaa Cherif, Aroua Anane, Nadia Ben Ali, Nadia Messaoud, Taieb Mrabet, Amel |
| description | The goal of the study was to examine the Apolipoprotein E (
APOE
) genotypes in a Tunisian sample of patients with Alzheimer disease (AD) and normal controls, and to compare the results with the findings from the literature. A hospital-based case–control study of two groups (58 patients with AD, 71 controls) was conducted. Patients received a detailed clinical history, neurological examination, neuropsychological testing and brain imaging. A neurological examination and the Arabic version of the Mini-Mental State Examination were made for controls. Genotyping was performed using the PCR restriction fragment length polymorphism (PCR–RFLP) method. There were no statistical differences in age (
p
= 0.05) and gender (
p
= 0.046) between the two groups. The
APOE
ε4/4 genotype was over represented in the AD group in comparison with the controls (13.3 vs. 2.8%). A significant increased risk of AD among
APOE
ε4 allele carriers was observed. The odds ratio for the association of AD patients with homozygous and heterozygous ε4 allele was, respectively, 5.40 (1.35–21.48) and 2.90 (1.27–6.62). Our results in addition to previously published genetic studies suggest that AD disease is multifactor in origin. Ethnicity, genetic and environmental factors contribute to AD risk in different ethnic groups. |
| doi_str_mv | 10.1007/s10072-011-0663-8 |
| format | Article |
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APOE
) genotypes in a Tunisian sample of patients with Alzheimer disease (AD) and normal controls, and to compare the results with the findings from the literature. A hospital-based case–control study of two groups (58 patients with AD, 71 controls) was conducted. Patients received a detailed clinical history, neurological examination, neuropsychological testing and brain imaging. A neurological examination and the Arabic version of the Mini-Mental State Examination were made for controls. Genotyping was performed using the PCR restriction fragment length polymorphism (PCR–RFLP) method. There were no statistical differences in age (
p
= 0.05) and gender (
p
= 0.046) between the two groups. The
APOE
ε4/4 genotype was over represented in the AD group in comparison with the controls (13.3 vs. 2.8%). A significant increased risk of AD among
APOE
ε4 allele carriers was observed. The odds ratio for the association of AD patients with homozygous and heterozygous ε4 allele was, respectively, 5.40 (1.35–21.48) and 2.90 (1.27–6.62). Our results in addition to previously published genetic studies suggest that AD disease is multifactor in origin. Ethnicity, genetic and environmental factors contribute to AD risk in different ethnic groups.</description><identifier>ISSN: 1590-1874</identifier><identifier>EISSN: 1590-3478</identifier><identifier>DOI: 10.1007/s10072-011-0663-8</identifier><identifier>PMID: 21710128</identifier><language>eng</language><publisher>Milan: Springer Milan</publisher><subject>Age ; Aged ; Aged, 80 and over ; Alleles ; Alzheimer Disease - genetics ; Alzheimer's disease ; Apolipoprotein E4 ; Apolipoprotein E4 - genetics ; Case-Control Studies ; Environmental factors ; Ethnic groups ; Female ; Gene Frequency ; Genetic Association Studies ; Genotype ; Genotyping ; Humans ; Male ; Measuring techniques ; Medicine ; Medicine & Public Health ; Middle Aged ; Neurodegenerative diseases ; Neuroimaging ; Neurology ; Neuroradiology ; Neurosciences ; Neurosurgery ; Original Article ; Polymerase chain reaction ; Population genetics ; Psychiatry ; Psychology ; Restriction fragment length polymorphism ; Statistics ; Tunisia</subject><ispartof>Neurological sciences, 2012-02, Vol.33 (1), p.33-37</ispartof><rights>Springer-Verlag 2011</rights><rights>Springer-Verlag 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-688ade2b9af91452d28227129025168033bacdc00f13d2138f9aca8fc170faa03</citedby><cites>FETCH-LOGICAL-c402t-688ade2b9af91452d28227129025168033bacdc00f13d2138f9aca8fc170faa03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10072-011-0663-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10072-011-0663-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27907,27908,41471,42540,51302</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21710128$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rassas, Afef Achouri</creatorcontrib><creatorcontrib>Mrabet Khiari, Hela</creatorcontrib><creatorcontrib>Hadj Fredj, Sondes</creatorcontrib><creatorcontrib>Sahnoun, Safa</creatorcontrib><creatorcontrib>Batti, Hend</creatorcontrib><creatorcontrib>Zakraoui, Nouria Oudiaa</creatorcontrib><creatorcontrib>Cherif, Aroua</creatorcontrib><creatorcontrib>Anane, Nadia</creatorcontrib><creatorcontrib>Ben Ali, Nadia</creatorcontrib><creatorcontrib>Messaoud, Taieb</creatorcontrib><creatorcontrib>Mrabet, Amel</creatorcontrib><title>High APOE epsilon 4 allele frequencies associated with Alzheimer disease in a Tunisian population</title><title>Neurological sciences</title><addtitle>Neurol Sci</addtitle><addtitle>Neurol Sci</addtitle><description>The goal of the study was to examine the Apolipoprotein E (
APOE
) genotypes in a Tunisian sample of patients with Alzheimer disease (AD) and normal controls, and to compare the results with the findings from the literature. A hospital-based case–control study of two groups (58 patients with AD, 71 controls) was conducted. Patients received a detailed clinical history, neurological examination, neuropsychological testing and brain imaging. A neurological examination and the Arabic version of the Mini-Mental State Examination were made for controls. Genotyping was performed using the PCR restriction fragment length polymorphism (PCR–RFLP) method. There were no statistical differences in age (
p
= 0.05) and gender (
p
= 0.046) between the two groups. The
APOE
ε4/4 genotype was over represented in the AD group in comparison with the controls (13.3 vs. 2.8%). A significant increased risk of AD among
APOE
ε4 allele carriers was observed. The odds ratio for the association of AD patients with homozygous and heterozygous ε4 allele was, respectively, 5.40 (1.35–21.48) and 2.90 (1.27–6.62). Our results in addition to previously published genetic studies suggest that AD disease is multifactor in origin. Ethnicity, genetic and environmental factors contribute to AD risk in different ethnic groups.</description><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alleles</subject><subject>Alzheimer Disease - genetics</subject><subject>Alzheimer's disease</subject><subject>Apolipoprotein E4</subject><subject>Apolipoprotein E4 - genetics</subject><subject>Case-Control Studies</subject><subject>Environmental factors</subject><subject>Ethnic groups</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic Association Studies</subject><subject>Genotype</subject><subject>Genotyping</subject><subject>Humans</subject><subject>Male</subject><subject>Measuring techniques</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neurodegenerative diseases</subject><subject>Neuroimaging</subject><subject>Neurology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Neurosurgery</subject><subject>Original Article</subject><subject>Polymerase chain reaction</subject><subject>Population genetics</subject><subject>Psychiatry</subject><subject>Psychology</subject><subject>Restriction fragment length polymorphism</subject><subject>Statistics</subject><subject>Tunisia</subject><issn>1590-1874</issn><issn>1590-3478</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkcFqFTEUhgex2Nr6AG4kuHE19pwkM5NZllKtUKiLdh3OzZxpU3IzYzKD1Kc3l3tVEMRNEsj3_znhq6q3CB8RoDvPu1XWgFhD26ravKhOsOmhVrozLw9nNJ0-rl7n_AQAqFG9qo4ldggozUlF1_7hUVx8vb0SPGcfpii0oBA4sBgTf1s5Os9ZUM6T87TwIL77pSTCj0f2W05i8Jkps_BRkLhbo8-eopineQ20-CmeVUcjhcxvDvtpdf_p6u7yur65_fzl8uKmdhrkUrfG0MBy09PYo27kII2UHcoeZIOtAaU25AYHMKIaJCoz9uTIjA47GIlAnVYf9r1zmsrYebFbnx2HQJGnNdu-0a0Ghf3_SYmo2wa7Qr7_i3ya1hTLNwoEqkzV7yDcQy5NOSce7Zz8ltKzRbA7Q3bvyRZPdufJmpJ5dyheN1sefid-iSmA3AO5XMUHTn9e_nfrT04zm-k</recordid><startdate>20120201</startdate><enddate>20120201</enddate><creator>Rassas, Afef Achouri</creator><creator>Mrabet Khiari, Hela</creator><creator>Hadj Fredj, Sondes</creator><creator>Sahnoun, Safa</creator><creator>Batti, Hend</creator><creator>Zakraoui, Nouria Oudiaa</creator><creator>Cherif, Aroua</creator><creator>Anane, Nadia</creator><creator>Ben Ali, Nadia</creator><creator>Messaoud, Taieb</creator><creator>Mrabet, Amel</creator><general>Springer Milan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20120201</creationdate><title>High APOE epsilon 4 allele frequencies associated with Alzheimer disease in a Tunisian population</title><author>Rassas, Afef Achouri ; Mrabet Khiari, Hela ; Hadj Fredj, Sondes ; Sahnoun, Safa ; Batti, Hend ; Zakraoui, Nouria Oudiaa ; Cherif, Aroua ; Anane, Nadia ; Ben Ali, Nadia ; Messaoud, Taieb ; Mrabet, Amel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-688ade2b9af91452d28227129025168033bacdc00f13d2138f9aca8fc170faa03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alleles</topic><topic>Alzheimer Disease - genetics</topic><topic>Alzheimer's disease</topic><topic>Apolipoprotein E4</topic><topic>Apolipoprotein E4 - genetics</topic><topic>Case-Control Studies</topic><topic>Environmental factors</topic><topic>Ethnic groups</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic Association Studies</topic><topic>Genotype</topic><topic>Genotyping</topic><topic>Humans</topic><topic>Male</topic><topic>Measuring techniques</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neurodegenerative diseases</topic><topic>Neuroimaging</topic><topic>Neurology</topic><topic>Neuroradiology</topic><topic>Neurosciences</topic><topic>Neurosurgery</topic><topic>Original Article</topic><topic>Polymerase chain reaction</topic><topic>Population genetics</topic><topic>Psychiatry</topic><topic>Psychology</topic><topic>Restriction fragment length polymorphism</topic><topic>Statistics</topic><topic>Tunisia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rassas, Afef Achouri</creatorcontrib><creatorcontrib>Mrabet Khiari, Hela</creatorcontrib><creatorcontrib>Hadj Fredj, Sondes</creatorcontrib><creatorcontrib>Sahnoun, Safa</creatorcontrib><creatorcontrib>Batti, Hend</creatorcontrib><creatorcontrib>Zakraoui, Nouria Oudiaa</creatorcontrib><creatorcontrib>Cherif, Aroua</creatorcontrib><creatorcontrib>Anane, Nadia</creatorcontrib><creatorcontrib>Ben Ali, Nadia</creatorcontrib><creatorcontrib>Messaoud, Taieb</creatorcontrib><creatorcontrib>Mrabet, Amel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rassas, Afef Achouri</au><au>Mrabet Khiari, Hela</au><au>Hadj Fredj, Sondes</au><au>Sahnoun, Safa</au><au>Batti, Hend</au><au>Zakraoui, Nouria Oudiaa</au><au>Cherif, Aroua</au><au>Anane, Nadia</au><au>Ben Ali, Nadia</au><au>Messaoud, Taieb</au><au>Mrabet, Amel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High APOE epsilon 4 allele frequencies associated with Alzheimer disease in a Tunisian population</atitle><jtitle>Neurological sciences</jtitle><stitle>Neurol Sci</stitle><addtitle>Neurol Sci</addtitle><date>2012-02-01</date><risdate>2012</risdate><volume>33</volume><issue>1</issue><spage>33</spage><epage>37</epage><pages>33-37</pages><issn>1590-1874</issn><eissn>1590-3478</eissn><abstract>The goal of the study was to examine the Apolipoprotein E (
APOE
) genotypes in a Tunisian sample of patients with Alzheimer disease (AD) and normal controls, and to compare the results with the findings from the literature. A hospital-based case–control study of two groups (58 patients with AD, 71 controls) was conducted. Patients received a detailed clinical history, neurological examination, neuropsychological testing and brain imaging. A neurological examination and the Arabic version of the Mini-Mental State Examination were made for controls. Genotyping was performed using the PCR restriction fragment length polymorphism (PCR–RFLP) method. There were no statistical differences in age (
p
= 0.05) and gender (
p
= 0.046) between the two groups. The
APOE
ε4/4 genotype was over represented in the AD group in comparison with the controls (13.3 vs. 2.8%). A significant increased risk of AD among
APOE
ε4 allele carriers was observed. The odds ratio for the association of AD patients with homozygous and heterozygous ε4 allele was, respectively, 5.40 (1.35–21.48) and 2.90 (1.27–6.62). Our results in addition to previously published genetic studies suggest that AD disease is multifactor in origin. Ethnicity, genetic and environmental factors contribute to AD risk in different ethnic groups.</abstract><cop>Milan</cop><pub>Springer Milan</pub><pmid>21710128</pmid><doi>10.1007/s10072-011-0663-8</doi><tpages>5</tpages></addata></record> |
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| subjects | Age Aged Aged, 80 and over Alleles Alzheimer Disease - genetics Alzheimer's disease Apolipoprotein E4 Apolipoprotein E4 - genetics Case-Control Studies Environmental factors Ethnic groups Female Gene Frequency Genetic Association Studies Genotype Genotyping Humans Male Measuring techniques Medicine Medicine & Public Health Middle Aged Neurodegenerative diseases Neuroimaging Neurology Neuroradiology Neurosciences Neurosurgery Original Article Polymerase chain reaction Population genetics Psychiatry Psychology Restriction fragment length polymorphism Statistics Tunisia |
| title | High APOE epsilon 4 allele frequencies associated with Alzheimer disease in a Tunisian population |
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