PKCε Promotes Oncogenic Functions of ATF2 in the Nucleus while Blocking Its Apoptotic Function at Mitochondria

The transcription factor ATF2 elicits oncogenic activities in melanoma and tumor suppressor activities in nonmalignant skin cancer. Here, we identify that ATF2 tumor suppressor function is determined by its ability to localize at the mitochondria, where it alters membrane permeability following geno...

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Veröffentlicht in:	Cell 2012-02, Vol.148 (3), p.543-555
Hauptverfasser:	Lau, Eric, Kluger, Harriet, Varsano, Tal, Lee, KiYoung, Scheffler, Immo, Rimm, David L., Ideker, Trey, Ronai, Ze'ev A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating Transcription Factor 2 - metabolism Apoptosis Cell Line Cell Line, Tumor Cell Nucleus - metabolism Cytosol - metabolism DNA Damage Fibroblasts - metabolism genotoxicity Hexokinase - metabolism Humans melanoma Melanoma - metabolism membrane permeability mitochondria Mitochondria - metabolism physiological transport Prognosis protein kinase C Protein Kinase C-epsilon - metabolism Protein Transport skin neoplasms transcription factors Voltage-Dependent Anion Channel 1 - metabolism
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